Implementation of the regional program of cervical cancer screening by liquid-based cytology in the Rostov region

The aim of this study was to screen the suspected cervical cancer patients (n=100) by liquid-based cytology and conventional pap’s smear followed by colposcopic biopsy from July 2016 to June 2017. In conventional pap’s test, 73 cases were true negative whereas 25 cases were false negative. However, in liquid-based cytology, 68 cases were true negative and 23 cases were false negative. Finally when colposcopic examinations were done, 61 cases were true negative and 15 cases were false negative. The sensitivity of liquid-based cytology was 11.5% for cervical cancer screening which was more than the conventional pap’s smear (3.8%). In conclusion, liquid-based cytology should be more preferable method than the than conventional pap’s smear for the diagnosis of precancerous lesion of the cervix.

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Cervical Cancer Screening: Comparison of conventional Pap smear test, liquid-based cytology and human papillomavirus testing as stand-alone or co-testing strategies

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-20-1003 ◽

2020 ◽

pp. cebp.1003.2020

Author(s):

Linda A Liang ◽

Thomas Einzmann ◽

Arno Franzen ◽

Katja Schwarzer ◽

Gunther Schauberger ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Pap Smear ◽

Test Liquid ◽

Pap Smear Test ◽

Smear Test ◽

Testing Strategies ◽

Liquid Based Cytology

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HPV for cervical cancer screening (HPV FOCAL): Complete Round 1 results of a randomized trial comparing HPV-based primary screening to liquid-based cytology for cervical cancer

International Journal of Cancer ◽

10.1002/ijc.30454 ◽

2016 ◽

Vol 140 (2) ◽

pp. 440-448 ◽

Cited By ~ 37

Author(s):

Gina S. Ogilvie ◽

Mel Krajden ◽

Dirk van Niekerk ◽

Laurie W. Smith ◽

Darrel Cook ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Screening ◽

Randomized Trial ◽

Cervical Cancer Screening ◽

Primary Screening ◽

Liquid Based Cytology

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PCN23 ECONOMIC EVALUATION ON LIQUID-BASED CYTOLOGY IN THE CERVICAL CANCER SCREENING PROGRAM IN TAIWAN

Value in Health ◽

10.1016/s1098-3015(11)73115-1 ◽

2010 ◽

Vol 13 (7) ◽

pp. A514

Author(s):

IHI Chow ◽

SL You ◽

RF Pwu ◽

CH Tang

Keyword(s):

Cervical Cancer ◽

Economic Evaluation ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Screening Program ◽

Cancer Screening Program ◽

Cervical Cancer Screening Program ◽

Liquid Based Cytology

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European guidelines for quality assurance in cervical cancer screening: recommendations for collecting samples for conventional and liquid-based cytology*

Cytopathology ◽

10.1111/j.1365-2303.2007.00464.x ◽

2007 ◽

Vol 18 (3) ◽

pp. 133-139 ◽

Cited By ~ 58

Author(s):

M. Arbyn ◽

A. Herbert ◽

U. Schenck ◽

P. Nieminen ◽

J. Jordan ◽

...

Keyword(s):

Cervical Cancer ◽

Quality Assurance ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

European Guidelines ◽

Liquid Based Cytology

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A comparison of liquid-based and conventional cytology using data for cervical cancer screening from the Japan Cancer Society

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyz161 ◽

2019 ◽

Vol 50 (2) ◽

pp. 138-144

Author(s):

Kiyoshi Ito ◽

Ryusei Kimura ◽

Hiroshi Konishi ◽

Nobuyoshi Ozawa ◽

Nobuo Yaegashi ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Cancer Society ◽

Detection Rates ◽

Predictive Values ◽

Conventional Cytology ◽

Significant Difference ◽

Liquid Based Cytology ◽

Using Data

Abstract Objective Liquid-based cytology has replaced conventional cytology in cervical cancer screening in many countries. However, a detailed comparison of liquid-based cytology with conventional cytology has not been reported in Japan. Therefore, the aim of the study is to evaluate efficacy of liquid-based cytology in Japan. Methods We first evaluated the prevalence of use of liquid-based cytology and then examined the efficacy of liquid-based cytology and conventional cytology for detecting CIN and the rate of unsatisfactory specimens using data from cancer screening collected by the Japanese Cancer Society from FY2011 to FY2014. A Poisson regression model with random effects analyses was used to classify histological outcomes and unsatisfactory specimens using liquid-based cytology compared to conventional cytology. Results A total of 3 815 131 women were analyzed in the study. The rate of liquid-based cytology increased from approximately 8% in FY2011 to 37% in FY2014. Compared to conventional cytology, the detection rates with liquid-based cytology were significantly higher (1.42 times) for CIN1+ [detection rate ratio (DRR) = 1.42, 95% confidence interval (CI) 1.35–1.48, P < 0.001] and CIN2+ (DRR = 1.16, 95% CI 1.08–1.25, P < 0.001). Positive predictive value ratios of CIN1+ and CIN2+ were also significantly higher for liquid-based cytology than for conventional cytology. However, there was no significant difference between liquid-based cytology and conventional cytology for detection rates and positive predictive values of CIN3+ and cancer. The rate of unsatisfactory specimens was significantly lower with liquid-based cytology compared to conventional cytology (DRR = 0.07, 95% CI 0.05–0.09, P < 0.001). Conclusions In order to avoid the unsatisfactory specimens in cervical cancer screening, the results of this study did indicate that liquid-based cytology was more useful than conventional cytology in practical standpoints.

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