Information technology for the analysis of CT perfusion in assessing the effectiveness of treatment for glioblastoma

Purpose of the study. To develop an information technology for calculating perfusion computed tomography parameters and to evaluate the effectiveness of using the proposed program in the differential diagnosis of continued glioblastoma growth and post-radiation necrosis. Materials and methods. We examined 53 patients who were treated at the Samara Clinical Oncological Dispensary. All patients underwent CT scan in perfusion mode. The results of using the program were compared with the data that were calculated on the workstation of the GE Discovery CT750 HD computed tomograph. Results. Significant differences were found in CBV and CBF perfusion indices in groups with continued growth and post-radiation necrosis, verified by biopsy. The parameters calculated using the developed program did not differ significantly from the results obtained on a standard workstation. Conclusion. The application of the developed computer program for the analysis of CT perfusion does not depend on the equipment manufacturer, works with standard DICOM data, which increases the availability of a valuable diagnostic method. The results obtained using the proposed information technology make it possible to differentiate the continued growth of glioblastoma from post-radiation necrosis.

Download Full-text

Magnetic resonance imaging and perfusion computed tomography capacities in brain glial tumors diagnosis

Kazan medical journal ◽

10.17750/kmj2015-949 ◽

2015 ◽

Vol 96 (6) ◽

pp. 949-952

Author(s):

A V Balandina ◽

A V Kapishnikov ◽

S V Kozlov

Keyword(s):

Magnetic Resonance Imaging ◽

Computed Tomography ◽

Magnetic Resonance ◽

Radiation Necrosis ◽

Resonance Imaging ◽

Glial Tumors ◽

Perfusion Computed Tomography ◽

Before And After ◽

Degree Of Malignancy ◽

Residual Tissue

Aim. To study magnetic resonance imaging and perfusion computed tomography capacities in the glial tumors diagnosis. Methods. 50 patients were examined using magnetic resonance imaging and perfusion computed tomography before and after treatment of glial tumors. Results. Perfusion computed tomography followed by pathomorphologic study confirmed the presence of glioblastoma in 48 patients before treatment. The presence of glioblastoma grade 4 was confirmed in 48 patients according to histological findings, and secondary (metastatic) tumors were identified in 2 patients. Glial tumors signs were revealed in all patients after MRI examination. Diagnostic tests using both methods were performed after treatment. The presence of residual tissue and radiation necrosis was not always accurately detected when using magnetic resonance imaging. During perfusion computed tomography performed on 32 patients continued tumor growth was identified in 28 patients, and presence of radiation necrosis - in 4. Histological examination confirmed the diagnosis accuracy in 24 patients, and presence of post-radiation changes in 4 patients. Conclusion. The data clearly demonstrate the need for the complex use of magnetic resonance imaging and perfusion computed tomography in suspected glial brain tumors before and after treatment, what allows to reliably estimate the presence of neoplasms, specify the location and degree of malignancy, correct further diagnostic and therapeutic tactics.

Download Full-text

Abstract P140: Do Perfusion Computed Tomography Abnormalities in Patients With Transient Ischemic Attack Predict Subsequent Ischemic Stroke and Cardiovascular Event

Stroke ◽

10.1161/str.52.suppl_1.p140 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Aisha Abdulrazaq ◽

Muhammad F Ishfaq ◽

Sachin Bhagavan ◽

Ammad Ishfaq ◽

Brandi R French ◽

...

Keyword(s):

Computed Tomography ◽

Ischemic Stroke ◽

Cardiovascular Events ◽

Ct Perfusion ◽

Mean Transit Time ◽

Imaging Protocol ◽

Perfusion Computed Tomography ◽

Blood Flow Reduction ◽

Ischemic Attack

Background and purpose: To determine if computed tomography (CT) perfusion (CTP) abnormalities in patients with transient ischemic attacks (TIA) are associated with development of ischemic strokes or adverse cardiovascular events within 24 months. Methods: Patients with a diagnosis of TIA who underwent CTP within 24 hours of symptom onset as part of the stroke/TIA imaging protocol were analysed. Abnormality was defined as an area of well demarcated mean transit time delay and/or cerebral blood flow reduction corresponding to an arterial territory as identified by an independent neuroradiologist. The patients were followed for at least 3 months and up to 24 months to identify occurrence of ischemic stroke and cardiovascular events (myocardial infarction or ischemia). Results: A total of 78 patients (mean age 67.60 +/- 15.1 ; 48 were men) with a diagnosis of TIA. A total of 17 patients (22%) had documented CTP abnormalities. Patients with CTP abnormalities were older and more likely to be men. There was no difference in the rates of ischemic stroke (5.9 % vs 3.3 %), or cardiovascular events (0% versus 1.6 %) when patients with CTP abnormalities were compared to those with normal CTP. Conclusions: In patients with TIA, an abnormal CTP does not predict the occurence of new ischemic stroke or cardiovascular events during follow up.

Download Full-text

Perfusion Computed Tomography (PCT) adopting different perfusion metrics: Recurrence of brain metastasis or radiation necrosis?

European Journal of Radiology ◽

10.1016/j.ejrad.2011.02.068 ◽

2012 ◽

Vol 81 (6) ◽

pp. 1246-1252 ◽

Cited By ~ 9

Author(s):

Antonello Vidiri ◽

Antonino Guerrisi ◽

Valentina Pinzi ◽

Alessandra Fabi ◽

Maria Alessandra Mirri ◽

...

Keyword(s):

Computed Tomography ◽

Brain Metastasis ◽

Radiation Necrosis ◽

Perfusion Computed Tomography

Download Full-text

Capabilities of perfusion computed tomography in colorectal cancer detection and differential diagnosis of pathological conditions of the colon. Early results

HERALD of North-Western State Medical University named after I I Mechnikov ◽

10.17816/mechnikov201911419-26 ◽

2020 ◽

Vol 11 (4) ◽

pp. 19-26

Author(s):

Maksim Yu. Kabanov ◽

Irina K. Borovik ◽

Mariya Ya. Belikova ◽

Konstantin V. Sementsov ◽

Irina E. Itskovich ◽

...

Keyword(s):

Colorectal Cancer ◽

Computed Tomography ◽

Cancer Detection ◽

Ct Perfusion ◽

Perfusion Technique ◽

Perfusion Computed Tomography ◽

Pathological Conditions ◽

Early Results ◽

Preoperative Ct ◽

Inflammatory Bowel

The article presents the results of preoperative CT diagnostics of colorectal cancer using perfusion technique. It was found that CT perfusion can improve the diagnostics of local prevalence of colon cancer compared to standard computed tomography, as well as to differentiate colorectal cancer and inflammatory bowel disease.

Download Full-text

Hyperperfusion on perfusion computed tomography following revascularization for acute stroke

Acta Radiologica ◽

10.1080/02841850510021607 ◽

2005 ◽

Vol 46 (6) ◽

pp. 610-615 ◽

Cited By ~ 13

Author(s):

T. B. Nguyen ◽

C. Lum ◽

J. D. Eastwood ◽

P. K. Stys ◽

M. Hogan ◽

...

Keyword(s):

Computed Tomography ◽

Acute Stroke ◽

Cerebral Blood Volume ◽

Ct Perfusion ◽

Intravenous Thrombolysis ◽

Additional Patient ◽

Ischemic Brain ◽

Perfusion Computed Tomography ◽

Arterial Thrombolysis

Purpose: To describe the findings of hyperperfusion on perfusion computed tomography (CT) in four patients following revascularization for acute stroke. Material and Methods: In 2002–2003, among a series of 6 patients presenting with an acute stroke and treated with intra-arterial thrombolysis, we observed the presence of hyperperfusion in 3 patients on the follow-up CT perfusion. We included an additional patient who was treated with intravenous thrombolysis and who had hyperperfusion on the follow-up CT perfusion. We retrospectively analyzed their CT perfusion maps. Cerebral blood volume (CBV) and cerebral blood flow (CBF) maps were compared between the affected territory and the normal contralateral hemisphere. Results: In the four patients, the mean CBV and CBF were 3.6±2.0 ml/100 g and 39±25 ml/100 g/min in the affected territory compared to the normal side (mean CBV = 2.7±2.1 ml/100 g, mean CBF = 27±23 ml/100 g/min). There was no intracranial hemorrhage in the hyperperfused territories. At follow-up CT, some hyperperfused brain areas progressed to infarction, while others retained normal white to gray matter differentiation. Conclusion: CT perfusion can demonstrate hyperperfusion, which can be seen in an ischemic brain territory following recanalization.

Download Full-text

Perfusion Computed Tomography Scan Imaging in Differentiation of Benign from Malignant Parotid Lesions

International Archives of Otorhinolaryngology ◽

10.1055/s-0039-1697005 ◽

2019 ◽

Vol 24 (02) ◽

pp. e160-e169

Author(s):

Masume Niazi ◽

Maryam Mohammadzadeh ◽

Kayvan Aghazadeh ◽

Hashem Sharifian ◽

Ebrahim Karimi ◽

...

Keyword(s):

Computed Tomography ◽

Parotid Gland ◽

Malignant Tumors ◽

Ct Perfusion ◽

Mean Transit Time ◽

Perfusion Ct ◽

Perfusion Computed Tomography ◽

Parotid Tumors ◽

The Mean ◽

Malignant Parotid Tumors

Abstract Introduction The most common site of salivary gland tumors is the parotid gland. Computed tomography (CT), magnetic resonance imaging (MRI), and sonography are imaging modalities to differentiate benign from malignant parotid tumors. Objective The aim of this study is the evaluation of the diagnostic value of perfusion CT for differentiating histological categorization of benign and malignant parotid tumors. Methods A total of 29 patients with parotid neoplasms were enrolled in this study. Mean age and all CT perfusion variables (gradient and permeability, blood flow [BF], blood volume [BV], mean transit time [MTT], permeability surface [PS], maximum intensity projection [MIP], time-density curve [TDC], and time to peak [TTP]) were compared among three groups (malignant tumors [MTs], Warthin's tumor [WT] and pleomorphic adenomas [PA]). Results The mean age of the patients was 55.9 ± 14.1 (26–77), and 15 of them were male (51.7%). Eleven lesions were PAs [37.9%], 8 lesions were WTs (27.6%0 and 10 lesions (34.5%) were MTs (6 acinic cell carcinomas [ACCs], 3 adenocystic carcinomas [AdCCs], and 1 mucoepidermoid carcinoma [MEC]). The mean age of the patients with WTs was 62 ± 7.5 years; 52 ± 14.2 for patients with Pas, and 55.2 ± 17.2 for those with MTs (p = 0.32). The mean MIP was 122.7 ± 12.2 in WT, while it was 80.5 ± 19.5 in PA, and 76.2 ± 27.1 in MTs (p < 0.001); The mean MIP for WT was higher than for PAs and MTs; the values of MTs and PAs were not statistically different. The average of BF, BV, and curve peak were higher in WTs in comparison with the other two groups, and curve time 2 and TTP were higher in PAs in comparison with MTs. Conclusion Based on this study, perfusion CT of the parotid gland and its parameters can distinguish between benign and malignant parotid masses.

Download Full-text

Perfusion Computed Tomography and its Application in Oncologic Practice

Current Molecular Imaginge ◽

10.2174/2211555211302010005 ◽

2013 ◽

Vol 2 (1) ◽

pp. 30-41

Author(s):

Rosalind Mitchell Hay ◽

Sofia Gourtsoyianni ◽

Vicky Goh

Keyword(s):

Computed Tomography ◽

Perfusion Computed Tomography

Download Full-text

Shifting of global aphasia to Wernicke’s aphasia in a patient with intact motor function: a case report

BMC Neurology ◽

10.1186/s12883-021-02131-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ya-Chi Chuang ◽

Chuan-Ching Liu ◽

I-Ching Yu ◽

Yu-Lin Tsai ◽

Shin-Tsu Chang

Keyword(s):

Computed Tomography ◽

Right Hemisphere ◽

Single Photon ◽

Ct Perfusion ◽

Single Case ◽

Photon Emission ◽

Emission Computed Tomography ◽

Speech Fluency ◽

Language Functions ◽

The Right

Abstract Background Global aphasia without hemiparesis (GAWH) is a rare stroke syndrome characterized by the dissociation of motor and language functions. Here, we present a case of GAWH with the patient later regaining speech fluency. Case presentation A 73-year-old man was admitted to our emergency department immediately after an episode of syncope. On arrival, we noted his global aphasia but without any focal neurologic signs. Computed tomography (CT) perfusion scans showed a large hypodense region over his left perisylvian area. Under the impression of acute ischaemic stroke, he received recombinant tissue plasminogen activator (rtPA) injection and was treated as an inpatient. The patient was later discharged with GAWH status and received regular speech rehabilitation. After 14 months of rehabilitation, the patient gradually recovered his language expression ability. The degree of aphasia was evaluated with the Concise Chinese Aphasia Test (CCAT), and we obtained brain single photon emission computed tomography (SPECT) scans to assess cerebral blood flow. Conclusion A patient with severe impairments of Broca’s and Wernicke’s areas was able to talk fluently despite being unintelligible. SPECT revealed relative high level of radioactivity uptake in the right frontal lobe, suggesting the deficits in speech fluency could have been compensated by the right hemisphere. Although this is a single case demonstration, the results may strengthen the role of the right hemisphere in GAWH patients and suggests additional study that examines the possible benefits of stimulating activity at right homologous regions for recovering language function after global aphasia.

Download Full-text