scholarly journals COVID-19 and thrombotic microangiopathy

2020 ◽  
Author(s):  
E. V. Sluhanchuk ◽  
V. O. Bitsadze ◽  
J. Kh. Khizroeva ◽  
M. V. Tretyakova ◽  
A. S. Shkoda ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Thrombotic Microangiopathy ◽  
Oral Anticoagulants ◽  
Severe Disease ◽  
Direct Oral Anticoagulants ◽  
Organ Damage ◽  
Multiple Organ ◽  
Terminal Organ ◽  
Pathogenetic Therapy

As shown by numerous studies conducted during the pandemic, the severe course of COVID-19 is accompanied by multiple organ failure. Cytokine storm, hypercoagulation, complement hyperactivation and other arms comprise the overall picture of the pathogenesis of the severe disease course. The frequent diagnosis of multiple microvascular thrombosis in lung, heart, and kidneys, as well as the presence of platelet-fibrin thrombi there and signs of terminal organ damage, suggest a possible involvement of thrombotic microangiopathy (TMA) in the development of multiple organ failure. In this regard, it is especially important to timely diagnose TMA and start pathogenetic therapy. These measures can significantly reduce mortality due to the novel disease. Heparins and direct oral anticoagulants are the mainstay for prevention and treatment of venous thromboembolism in patients with COVID-19, but their effectiveness in the presence of TMA is questionable. It has been proven that anticoagulants use in critically ill patients with COVID-19 for prevention of large vessel thrombosis is effective, but their role in the prevention of microthrombosis is not clear. Here we review the currently available information on thrombotic microangiopathy, as well as a review of literature data describing TMA-like conditions in COVID19, discuss potential pathophysiology of the condition development and proposed therapeutic approaches.

scholarly journals Organ protection and prevention of polyorgan insufficiency during high-risk percutaneous coronary intervention by using extracorporal membrane oxygenation

2021 ◽  
Vol 10 (2) ◽  
pp. 27-31
Author(s):  
R. A. Kornelyuk
Keyword(s):  
Percutaneous Coronary Intervention ◽  
High Risk ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Organ Dysfunction ◽  
Coronary Intervention ◽  
Organ Damage ◽  
Multiple Organ ◽  
Percutaneous Coronary ◽  
Va Ecmo

Aim. To compare the possibilities of venoarterial extracorporeal membrane oxygenation (VA ECMO) and intra-aortic balloon pump (IABP) to prevent organ damage and the development of multiple organ failure.Methods. According to the inclusion and exclusion criteria, 51 patients underwent the study. The patients were divided into 2 groups depending on the method of mechanical circulatory support used: VA ECMO (n = 29) and IABP (n = 22). To assess organ functions in the intra- and postoperative period, the results of instrumental and laboratory research methods, as well as data from complex scales of organ dysfunction, were analased.Results. Myocardial depression was observed in the IABP group in the intraoperative period of high-risk percutaneous coronary intervention and worse hemodynamic stability compared to the VA ECMO group was traced. Organ dysfunction and multiorgan failure developed more often in the IABP group, which was confirmed by laboratory specific markers.Conclusion. High-risk percutaneous coronary intervention with VA ECMO is accompanied by a lower incidence and severity of organ damage and multiple organ failure. Thus, the VA ECMO has better organ protective effects. 

scholarly journals COVID-19 and Fungal Infection

2020 ◽  
pp. 47-50
Author(s):  
Ji Hyun Lee ◽  
Hwa Jung Yook
Keyword(s):  
Fungal Infection ◽  
Multiple Organ Failure ◽  
World Health Organization ◽  
Organ Failure ◽  
Fungal Infections ◽  
Severe Disease ◽  
Multiple Organ ◽  
World Health ◽  
The World ◽  
Health Organization

In November 2019, the coronavirus disease-2019 (COVID-19) outbreak was first reported. The infection of COVID-19 has rapidly spread worldwide. Some have unapparent or mild symptoms, but some patients have fatal forms including respiratory or multiple organ failure. In March 2020, the World Health Organization announced COVID-19 as pandemic disease. The COVID-19 pandemic is a sudden, difficult-to-control, and severe disease that can also appear to patients in dermatology. However, understanding disease and experience with it is still insufficient. Therefore, we would like to review patients with fungal infections in the COVID-19 pandemic era.

Cyclosporine-associated Thrombotic Microangiopathy and Thrombocytopenia-associated Multiple Organ Failure

2014 ◽  
Vol 36 (2) ◽  
pp. e88-e90 ◽  
Author(s):  
Çağlar Ödek ◽  
Tanil Kendirli ◽  
Ayhan Yaman ◽  
Talia İleri ◽  
Zarife Kuloğlu ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Thrombotic Microangiopathy ◽  
Multiple Organ

Clinical case of periostitis in pregnant women complicated by sepsis

2020 ◽  
pp. 61-63
Author(s):  
S. Sh. Kakvaeva ◽  
M. A. Magomedova ◽  
A. N. Dzhalilova
Keyword(s):  
Pregnant Woman ◽  
Multiple Organ Failure ◽  
Pregnant Women ◽  
Organ Failure ◽  
Clinical Case ◽  
Clinical Observation ◽  
Infectious Agent ◽  
Modern Medicine ◽  
Multiple Organ ◽  
Number Of Patients

One of the most serious problems of modern medicine is sepsis. The number of patients undergoing this complication is 20–30 million (WHO) annually and has no tendency to decrease. Sepsis is characterized by severe multiple organ failure due to a violation of the response of the macroorganism to an infectious agent. Moreover, it is dangerous with high mortality. Sepsis often develops in patients with immunodeficiency conditions, which primarily include pregnant women. The article presents a clinical observation of a case of periostitis in a pregnant woman complicated by a septic state.

scholarly journals High-dose diquat poisoning: a case report

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110261
Author(s):  
Yanxia Huang ◽  
Renjing Zhang ◽  
Mei Meng ◽  
Dechang Chen ◽  
Yunxin Deng
Keyword(s):  
Renal Failure ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
High Dose ◽  
Severe Respiratory Failure ◽  
Aggressive Treatment ◽  
Lung Lesions ◽  
Pulmonary Lesions ◽  
New Treatment

Diquat is a widely used herbicide that is substituted for paraquat. With paraquat off the market, cases of diquat poisoning have been gradually increasing. The kidney is the most frequently impaired organ in diquat poisoning. Few cases of multiple organ failure caused by diquat have been reported. We herein describe a 30-year-old man who orally ingested about 160 mL of enriched diquat. Despite aggressive treatment, the patient’s condition progressed to multiple organ failure and death. The pulmonary lesions in this patient were different from those previously reported. This patient did not die of renal failure but of severe respiratory failure. He exhibited three different stages of pulmonary disease. The lung lesions in this case were unique. We hope that doctors will pay more attention to the lung lesions in patients with diquat poisoning in future and find new treatment methods to save the lives of such patients.

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