scholarly journals Features of the clinical course of chronic obstructive pulmonary disease and quality of life in patients with coexisting metabolic syndrome

2016 ◽  
Vol 97 (5) ◽  
pp. 681-686
Author(s):  
S A Kozhevnikova ◽  
A V Budnevskiy
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Metabolic Syndrome ◽  
Pulmonary Disease ◽  
Hospital Admissions ◽  
Clinical Course ◽  
Life Assessment ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Aim. To study the clinical course of chronic obstructive pulmonary disease in patients with metabolic syndrome and analyze the degree of influence of the metabolic syndrome components on chronic obstructive pulmonary disease and patients’ quality of life.Methods. 100 patients with chronic obstructive pulmonary disease were examined: 30 patients without metabolic syndrome (the first group) and 70 patients with metabolic syndrome (the second group). Anthropometric measurements (weight, height, body mass index, waist circumference), laboratory tests (levels of triglycerides, cholesterol, low- and high-density lipoproteins, fasting blood glucose, the oral glucose tolerance test), physical examination, quality of life assessment were performed.Results.Patients of the second group had statistically significant differences in the studied parameters in comparison with the first group. The number of exacerbations, calls to ambulance service, hospital admissions were 1.4; 1.3 and 1.5 times higher, respectively. Dyspnea intensity, cough and sputum score were 1.6; 1.7 and 1.6 times higher respectively as compared with the first group (pConclusion. Metabolic syndrome is associated with a more severe course of chronic obstructive pulmonary disease, which results in a higher frequency of exacerbations, hospital admissions, more severe clinical manifestations, greater influence of dyspnea on the physical activity limitation of patients, more severe airflow obstruction, low exercise tolerance with worse performance of everyday activities, emotional perception of the disease, worse psychosocial adaptation of patients.

scholarly journals Impact of Frailty on Hippocampal Volume in Patients with Chronic Obstructive Pulmonary Disease

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1103
Author(s):  
Shun Takahashi ◽  
Tsunahiko Hirano ◽  
Kasumi Yasuda ◽  
Tomohiro Donishi ◽  
Kazuyoshi Suga ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Depressive Symptoms ◽  
Pulmonary Disease ◽  
Hippocampal Volume ◽  
Life Assessment ◽  
World Health ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Brain frailty may be related to the pathophysiology of poor clinical outcomes in chronic obstructive pulmonary disease (COPD). This study examines the relationship between hippocampal subfield volumes and frailty and depressive symptoms, and their combined association with quality of life (QOL) in patients with COPD. The study involved 40 patients with COPD. Frailty, depressive symptoms and QOL were assessed using Kihon Checklist (KCL), Hospital Anxiety and Depression Scale (HADS), and World Health Organization Quality of Life Assessment (WHO/QOL-26). Anatomical MRI data were acquired, and volumes of the hippocampal subfields were obtained using FreeSurfer (version 6.0) (Harvard University, Boston, MA, USA). Statistically, HADS score had significant association with WHO/QOL-26 and KCL scores. KCL scores were significantly associated with volumes of left and right whole hippocampi, presubiculum and subiculum, but HADS score had no significant association with whole hippocampi or hippocampal subfield volumes. Meanwhile, WHO/QOL-26 score was significantly associated with volume of the left CA1. There was a significant association between frailty, depression, and QOL. Hippocampal pathology was related to frailty and, to some extent, with QOL in patients with COPD. Our results suggest the impact of frailty on hippocampal volume and their combined associations with poor QOL in COPD.

scholarly journals Protocol for an observational study to identify potential predictors of an acute exacerbation in patients with chronic obstructive pulmonary disease (the PACE Study)

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e043014
Author(s):  
Klaus Kenn ◽  
Rainer Gloeckl ◽  
Daniela Leitl ◽  
Tessa Schneeberger ◽  
Inga Jarosch ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Hospital Admissions ◽  
Negative Impact ◽  
Chronic Obstructive ◽  
Detailed Knowledge ◽  
Obstructive Pulmonary Disease

IntroductionAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) are the most critical events for patients with COPD that have a negative impact on patients’ quality of life, accelerate disease progression, and can result in hospital admissions and death. Although there is no distinct definition or detailed knowledge about AECOPD, it is commonly used as primary outcome in clinical studies. Furthermore, it may be difficult in clinical practice to differentiate the worsening of symptoms due to an AECOPD or to the development of heart failure. Therefore, it is of major clinical importance to investigate the underlying pathophysiology, and if possible, predictors of an AECOPD and thus to identify patients who are at high risk for developing an acute exacerbation.Methods and analysisIn total, 355 patients with COPD will be included prospectively to this study during a 3-week inpatient pulmonary rehabilitation programme at the Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee (Germany). All patients will be closely monitored from admission to discharge. Lung function, exercise tests, clinical parameters, quality of life, physical activity and symptoms will be recorded, and blood samples and exhaled air will be collected. If a patient develops an AECOPD, there will be additional comprehensive diagnostic assessments to differentiate between cardiac, pulmonary or cardiopulmonary causes of worsening. Follow-up measures will be performed at 6, 12 and 24 months.Exploratory data analyses methods will be used for the primary research question (screening and identification of possible factors to predict an AECOPD). Regression analyses and a generalised linear model with a binomial outcome (AECOPD) will be applied to test if predictors are significant.Ethics and disseminationThis study has been approved by the Ethical Committee of the Philipps University Marburg, Germany (No. 61/19). The results will be presented in conferences and published in a peer-reviewed journal.Trial registration numberNCT04140097.

Generic versus Disease-specific Instruments in Quality-of-life Assessment of Chronic Obstructive Pulmonary Disease

2006 ◽  
Vol 45 (02) ◽  
pp. 211-215 ◽  
Author(s):  
V. Vondra ◽  
M. Malý
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Well Being ◽  
Life Assessment ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sf 36 ◽  
Disease Specific

Summary Objectives: Chronic respiratory diseases may alter a patient’s social life and well-being. Measures of health-related quality of life have been proven to bring complementary information to functional assessments. The aim of the study was to describe the questionnaires that are most frequently used to measure this subjective construct in patients with chronic obstructive pulmonary disease (COPD) and to compare the responses obtained via administering one generic (SF-36) and one disease-specific questionnaire (St. George’s Respiratory Questionnaire; SGRQ) to patients with COPD. Methods: One group of patients (46 individuals) was used to evaluate the questionnaire’s performance in repeated administrations under unchanged conditions (reproducibility) and to study the correlations of corresponding domains of respective questionnaires. Responsiveness of both questionnaires was tested on another group of 129 patients measured before and after the therapeutic stay at the spa. Methods of cor-relational analysis (Spearman, intraclass, and canonical correlation coefficients) as well as the Wilcoxon rank test were used for statistical analysis. Results: Both questionnaires seem to be comprehensive outcome measures for patients with COPD, but some particular areas may not be covered with the same intensity (e.g. emotional problems). Reproducibility of both questionnaires was good and only small non-significant shifts were seen, particularly in physical and social functioning domains. In repeated measurement, the SGRQ seemed to be slightly more responsive to change than the SF-36. Conclusions: The idea of using generic and disease-specific questionnaires together probably represents the best approach to this topic. It may improve our knowledge and explain better the relationship between disease-specific changes in patient status and both disease-specific treatment and general functional status.

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