The Impact of Yoga on Inspiratory Muscle Performance in Veterans with COPD: A Pilot Study

2021 ◽  
Author(s):  
Nicole D. DeLuca ◽  
Jackeline P. Vajta Gomez ◽  
Isabel Vital ◽  
Lawrence P. Cahalin ◽  
Michael A. Campos
Keyword(s):  
Muscle Weakness ◽  
Depression Scale ◽  
Inspiratory Muscle ◽  
Muscle Performance ◽  
Inspiratory Pressure ◽  
Anxiety And Depression ◽  
Maximal Inspiratory Pressure ◽  
Walk Distance ◽  
Minute Walk Distance ◽  
Minute Walk

Abstract Chronic obstructive pulmonary disease (COPD) causes respiratory muscle weakness that leads to disabling dyspnea and poor functional performance. Therapies are often geared to improve inspiratory muscle performance. Yoga has been shown to improve exercise capacity, quality of life, and some pulmonary function measures in COPD, but little research has examined the effects of yoga training on inspiratory muscle performance. The purpose of this study was to investigate the effects of yoga training on inspiratory muscle performance in military veterans using the Test of Incremental Respiratory Endurance (TIRE). A prospective pilot study examined a 6-week yoga training program consisting of asana (poses) and pranayama (controlled breathing). Subjects had baseline inspiratory muscle weakness. The TIRE measured inspiratory muscle performance via the PrO2 device, providing maximal inspiratory pressure, sustained maximal inspiratory pressure, and inspiratory duration. Secondary measures included 6-minute walk distance, St. George Respiratory Questionnaire, Hospital Anxiety and Depression Scale, and spirometry. Mean age and BMI of subjects were 67 ± 3.6 years and 20.7 ± 3.3, respectively. The majority of subjects had severe (28.7%) or very severe (57.1%) COPD. Statistically significant improve m e n t s were seen in maximal inspiratory pressure (39.0 ± 14.1 cmH2O to 56.4 ± 20.6 cmH2O) and sustained maximal inspiratory pressure (244.1 ± 100.6 PTU to 308.1 ± 121.2 PTU). No statistically significant improvements we re observed in 6-minute walk distance, St. George Respiratory Questionnaire, Hospital Anxiety and Depression Scale, or spirometry. Yoga training has the potential in improve inspiratory muscle performance in veterans with severe to very severe COPD who present with inspiratory muscle weakness. This is of importance because improving inspira-tory muscle performance has been shown to improve COPD outcomes.

Abstract 2403: Inspiratory Muscle Training Decreases Central and Peripheral Sympathetic Activity Improves Reflex Vasodilatory Blood Flow in Patients with Chronic Heart Failure

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Priscila Mello ◽  
Grazia Guerra ◽  
Pedro Dall’ago ◽  
Suellen Borille ◽  
Maria U Rondom ◽  
...  
Keyword(s):  
Blood Flow ◽  
Muscle Weakness ◽  
Sympathetic Activity ◽  
Forearm Blood Flow ◽  
Inspiratory Muscle ◽  
Inspiratory Muscle Training ◽  
Inspiratory Pressure ◽  
Maximal Inspiratory Pressure ◽  
Muscle Training ◽  
Peripheral Sympathetic Activity

Background: Inspiratory muscle training (IMT) improves functional capacity of patients with CHF but the mechanisms of this effect are unknown. Objective: We tested the hypothesis that IMT could decrease sympathetic activity and improve the reflex muscle vasodilatory response during exercise in patients (CHF) and inspiratory muscle weakness. Methods: Six patients with CHF and inspiratory muscle weakness (maximal inspiratory pressure <70% of predicted) NYHA Class II–III, EF <35%, peak VO(2) < 20 ml/kg/min, were submitted to a IMT during 12 weeks (30 minute breathing with an inspiratory resistance of 30% of maximal inspiratory pressure). Muscle sympathetic nerve activity (MSNA) was recorded by microneurography, LF (sympathetic) and HF (parasympathetic) components of the heart rate variability and LF/HF ratio were assessed by the use of power spectral analysis of RR interval. Forearm blood flow (FBF) was measured by venous occlusion plethysmography at baseline and during hand grip (HG) manouver. Paired student t-test was used to analyze the impact of IMT in this population. Results: Compared to baseline, IMT significantly (p < 0,05) caused: an increase in inspiratory muscle force by 130%; a 15% reduction in MSNA (40 ± 1 vs 33 ± 1 bursts/min); an increase in forearm blood flow (0.8+/−0.1 mL/min/100 g) during HG manouver; a decrease in LF% (59 ± 5 vs 39 ± 3 U); an increase in HF% (40 ± 5 vs 61 ± 3 U); a decrease in LF/HF ratio (1,74 vs 0,66). Conclusions: Twelve weeks of Inspiratory muscle training in patients with CHF and inspiratory muscle weakness promoted a significant improvement in cardiovascular parameters, such as increase in limb blood flow, cardiac autonomic balance and baroreflex sensitivity, associated with a decrease in peripheral sympathetic activity.

scholarly journals Side-Alternating Vibration Training Improves Muscle Performance in a Patient with Late-Onset Pompe Disease

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Aneal Khan ◽  
Barbara Ramage ◽  
Ion Robu ◽  
Laura Benard
Keyword(s):  
Pompe Disease ◽  
Late Onset ◽  
Knee Extensor ◽  
Muscle Performance ◽  
Item Score ◽  
Walk Distance ◽  
Enzyme Replacement ◽  
Vibration Training ◽  
Minute Walk Distance ◽  
Minute Walk

Side-alternating vibration training (SAVT) was used for 15 weeks in a patient with Late-onset Pompe disease who had never used enzyme replacement or chaperone therapy. Prior to the use of SAVT, the patient had experienced declining muscle performance and her 6-minute walk distance decreased from 210 to 155 metres in 6 months. After SAVT, her 6-minute walk distance increased 70% from 166 to 282 metres, muscle jumping power increased by 64% from 83 to 166 watts, isometric knee extensor strength increased 17% from 38 to 44 Nm, and she achieved a more normal pattern of ankle, knee, and joint kinematics and kinetics. Her functional ability measured through the Rotterdam 9-item score was unchanged at 19/36. There were no elevations in serum creatine kinase or lactate. This is the first report, to our knowledge, of a performance improvement in a patient with Pompe disease using SAVT.

scholarly journals The BODE index and inspiratory muscle performance in COPD: Clinical findings and implications

2018 ◽  
Vol 6 ◽  
pp. 205031211881901 ◽  
Author(s):  
Magno F Formiga ◽  
Isabel Vital ◽  
Gisel Urdaneta ◽  
Kira Balestrini ◽  
Lawrence P Cahalin ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Airflow Obstruction ◽  
The Body ◽  
Inspiratory Muscle ◽  
Muscle Performance ◽  
Inspiratory Pressure ◽  
Chronic Obstructive ◽  
Maximal Inspiratory Pressure

Objectives: The Test of Incremental Respiratory Endurance is a novel testing method that provides a unique examination of one’s inspiratory muscle strength, work and endurance. Little is known about the relationship between inspiratory muscle performance and mortality risk in obstructive lung disease. We examined the relationship between the Test of Incremental Respiratory Endurance measures and the Body-mass index, airflow Obstruction, Dyspnea and Exercise index in chronic obstructive pulmonary disease. Methods: In all, 70 males with mild-to-very severe chronic obstructive pulmonary disease (mean ± standard deviation of 70.2 ± 5.9 years) underwent measurements of body-mass index, spirometry, dyspnea and a 6-min walk test from which the Body-mass index, airflow Obstruction, Dyspnea and Exercise score was calculated. The Test of Incremental Respiratory Endurance provided measures of maximal inspiratory pressure, sustained maximal inspiratory pressure and inspiratory duration. Results: All Test of Incremental Respiratory Endurance parameters inversely correlated with the Body-mass index, airflow Obstruction, Dyspnea and Exercise score: maximal inspiratory pressure (r = −0.355, p = 0.00), sustained maximal inspiratory pressure (r = −0.426, p = 0.00) and ID (r = −0.278, p = 0.02), with sustained maximal inspiratory pressure displaying the highest correlation. Independent significant correlations were also observed between the sustained maximal inspiratory pressure and all Body-mass index, airflow Obstruction, Dyspnea and Exercise score components, except for body-mass index. Finally, sustained maximal inspiratory pressure was significantly different among the Body-mass index, airflow Obstruction, Dyspnea and Exercise index quartiles. Discussion: The significant association between the Body-mass index, airflow Obstruction, Dyspnea and Exercise score and inspiratory muscle performance, in particular sustained maximal inspiratory pressure, suggests that these measures may have a potential prognostic value in the evaluation of chronic obstructive pulmonary disease.

scholarly journals Characteristics and health status of patients with and without confirmed HFpEF

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Deaton ◽  
F Forsyth ◽  
J Mant ◽  
D Edwards ◽  
R Hobbs ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Primary Care ◽  
Cohort Study ◽  
Health Status ◽  
Functional Impairment ◽  
Funding Source ◽  
Walk Distance ◽  
Minute Walk Distance ◽  
Minute Walk

Abstract Aims Patients with heart failure with preserved ejection fraction (HFpEF) are usually older and multi-morbid and diagnosis can be challenging. The aims of this cohort study were to confirm diagnosis of HFpEF in patients with possible HFpEF recruited from primary care, to compare characteristics and health status between those with and without HFpEF, and to determine factors associated with health status in patients with HFpEF. Methods Patients with presumed HFpEF were recruited from primary care practices and underwent clinical assessment and diagnostic evaluation as part of a longitudinal cohort study. Health status was measured by Montreal Cognitive Assessment (MOCA), 6-minute walk test, symptoms, and the Kansas City Cardiomyopathy Questionnaire (KCCQ), and quality of life (QoL) by EQ-5D-5L visual analogue scale (VAS). Results 151 patients (mean age 78.5±8.6 years, 40% women, mean EF 56% + 9.4) were recruited and 93 (61.6%) were confirmed HFpEF (those without HFpEF had other HF and cardiac diagnoses). Patients with and without HFpEF did not differ by age, MOCA, blood pressure, heart rate, NYHA class, proportion with atrial fibrillation, Charlson Comorbidity Index, or NT-ProBNP levels. Patients with HFpEF were more likely to be women, overweight or obese, frail, and to be more functionally impaired by 6 minute walk distance and gait speed than those without. Although not statistically significant, patients with HFpEF had clinically significant differences (&gt;5 points) on the physical limitations, symptom burden and clinical summary subscales of the KCCQ, but did not differ by other subscales or by EQ-5D-5L VAS (70±17 vs 73±19, p=0.385). More patients with HFpEF reported daytime dyspnoea (63% vs 46%, p=0.035) and fatigue (81% vs 61%, p=0.008), but not other symptoms compared to those without HFpEF. For both groups BMI was moderately negatively correlated with KCCQ subscale scores, and 6 minute walk distance was positively correlated with KCCQ subscales. Conclusions Nearly 40% were not confirmed as HFpEF indicating the challenges of diagnosis. Patients with confirmed HFpEF differed by sex, overweight/obesity, frailty, functional impairment, and symptoms but not by age or comorbidities from those without HFpEF. These differences were reflected in some subscale scores of the KCCQ, but not how patients reported their quality of life on the KCCQ QoL subscale and EQ-5D-5L VAS. Older patients with HFpEF reported relatively high QoL despite poor health status by functional impairment, frailty and symptoms. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): National Institute of Health Research School of Primary Care Research

scholarly journals Predictors of reduced 6-minute walk distance after COVID-19: a cohort study in Mexico

Pulmonology ◽  
2021 ◽  
Author(s):  
Alyson W. Wong ◽  
Stephanie López-Romero ◽  
Esperanza Figueroa-Hurtado ◽  
Saul Vazquez-Lopez ◽  
Kathryn M. Milne ◽  
...  
Keyword(s):  
Cohort Study ◽  
Walk Distance ◽  
Minute Walk Distance ◽  
Minute Walk

scholarly journals 42 Is Mitochondrial Function Measured by 31P Magnetic Resonance Spectroscopy Associated with Physical Performance in Older People with Functional Impairment?

2021 ◽  
Vol 50 (Supplement_1) ◽  
pp. i12-i42
Author(s):  
R R Chungath ◽  
M D Witham ◽  
C L Clarke ◽  
A Hutcheon ◽  
S Gandy ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Older People ◽  
Physical Performance ◽  
Functional Impairment ◽  
Resonance Spectroscopy ◽  
Walk Distance ◽  
31P Magnetic Resonance Spectroscopy ◽  
Minute Walk Distance ◽  
Minute Walk

Abstract Background Mitochondrial dysfunction has been proposed as a therapeutic target to improve muscle strength and endurance, but the contribution that mitochondrial dysfunction makes to impaired skeletal muscle performance in older people remains unclear. We studied the relationship between phosphocreatine recovery rate (a measure of skeletal muscle mitochondrial function) and physical performance in older people. Methods We analysed data from the Allopurinol in Functional Impairment (ALFIE) trial. Participants aged 65 and over, who were unable to walk 400 m in six minutes, underwent 31P magnetic resonance spectroscopy of the calf after exercise at baseline and at 20 weeks follow up. The phosphocreatine recovery half-life time (t-half) was derived as a measure of mitochondrial function. Participants also undertook the 6-minute walk distance, the Short Physical Performance Battery test (SPPB), and had muscle mass measured using bio-impedance analysis. Bivariate correlations and multivariable regression analyses were conducted to determine associations between t-half and baseline factors. Results One hundred and seventeen people underwent baseline 31P magnetic resonance spectroscopy, mean age 80.4 years (SD 6.0); 56 (48%) were female. Mean 6-minute walk was 291 m (SD 80) and mean SPPB score was 8.4 (SD 1.9). T-half was significantly correlated with SPPB score (r = 0.22, p = 0.02) but not with 6-minute walk distance (r = 0.10, p = 0.29). In multivariable linear regression, muscle mass and weight, but not t-half, were independently associated with SPPB score and with 6-minute walk distance. The change in t-half between baseline and 20 weeks was not significantly associated with the change in SPPB (r = 0.03, p = 0.79) or with the change in 6-minute walk distance (r = −0.11, p = 0.28). Conclusion Muscle mass, but not phosphocreatine recovery time, was associated with Short Physical Performance Battery score and 6-minute walk distance in this cohort of older people with functional impairment.

Six-Minute Walk Distance in Healthy Japanese Adults

2010 ◽  
Vol 11 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Neiko Ozasa ◽  
Takeshi Morimoto ◽  
Yutaka Furukawa ◽  
Hiroshi Hamazaki ◽  
Toru Kita ◽  
...  
Keyword(s):  
Walk Distance ◽  
Japanese Adults ◽  
Minute Walk Distance ◽  
Minute Walk
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