scholarly journals Diagnostics and the combined medical tactics at patients with erectile dysfunction at a empty sella syndrome

2020 ◽  
Vol 19 (1) ◽  
pp. 4-12
Author(s):  
Tigran G. Markosyan ◽  
Stefani S. Bolevich ◽  
Sergey S. Nikitin ◽  
Armida G. Markosyan ◽  
Natalia B. Korchazhkina
Keyword(s):  
Erectile Dysfunction ◽  
Hormone Replacement ◽  
Combined Treatment ◽  
Age Groups ◽  
Empty Sella ◽  
Hormonal Status ◽  
Color Flow ◽  
Empty Sella Syndrome ◽  
Complex Therapy ◽  
Transcranial Magnetotherapy

Background.The study of hormonal status in patients with erectile dysfunction (ED), especially the older and senior age groups, is most often limited to the evaluation of testosterone fractions Aim:demonstrate the effectiveness of transcranial magnetotherapy in a combined treatment regimen for patients with empty sella syndrome (ESS). Methods.Results of diagnostics examination and treatment of 118 patients with the ED hormonal form at the age of 2357 are studied. The expressiveness of disturbances of erectile function and signs of androgenic deficiency are estimated by means of questionnaires of AMS and a scale of Morley, the penil color flow Doppler ultrasound with intracavernous pharmacological tests is carried out, the hormonal status is estimated. At suspicion of neuroendocrine pathology MRI of the brain is executed. At all examined patients signs of decrease erectile functions are revealed. In 62 (52.5%) observations during MRI the picture of ESS is revealed. In 22 (18.6%) observations the changes of an eyeground demonstrating increase in intracranial pressure takes place, however loss of fields of vision is not observed in any of patient. Persistent headaches are noted in 19 (16.1%) observations. In 46 (39%) observations at patients with considerable obesity signs of disturbance of tolerance to glucose and insulin resistance are revealed. To patients hormone replacement therapy is appointed, at identification of a hyperprolactinemia agonists of dopamine receptors in an individual dosage under control of level of prolactin are used, therapy of intracranial hypertensia is carried out. In complex therapy transcranial magnetotherapy is used. Results.Therapy is effective, during treatment increase in frequency and duration of sexual intercourses is noted. At control Doppler researches of a penis improvement of a regional hemodynamics is noted. Cancellation of medicines lead to resuming of symptomatology of a disease. Conclusion.Thus, the research shows powerful value of a syndrome of ESS in a pathogeny of ED demanding multidisciplinary approach with involvement of adjacent specialists endocrinologists, neurologists and ophthalmologists. It is important to note that ESS, in most cases, is an accidental tomographic finding, at the same time often is followed by disturbance of tolerance to glucose, obesity, a metabolic syndrome. Introduction in complex therapy of transcranial magnetic influence substantially improves results of treatment of this category of patients, as due to additional stimulation of synthesis of pituitary hormones, and cerebral decompression.

Role of secondary empty sella syndrome in the development of erectile dysfunction

2018 ◽  
Vol 6 (3) ◽  
pp. 43-50 ◽  
Author(s):  
T.G. Markosyan ◽  
◽  
S.S. Bolevich ◽  
S.B. Bolevich ◽  
◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Empty Sella ◽  
Empty Sella Syndrome

scholarly journals Weiss-Kruszka Syndrome With Unreported Manifestations; Empty Sella Syndrome Associated With Growth Hormone Deficiency

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A619-A619
Author(s):  
Jisun Park ◽  
Su Jin Kim ◽  
GoHun Seo ◽  
Ji-Eun Lee
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Clinical Features ◽  
Recombinant Human Growth Hormone ◽  
Hormone Replacement ◽  
Empty Sella ◽  
Hormone Deficiency ◽  
Delayed Puberty ◽  
Chromosomal Microarray Analysis ◽  
Empty Sella Syndrome

Abstract Objective: Weiss-Kruszka syndrome (WSKA; MIM#618,619) is a rare, autosomal dominant disorder associated with zinc finger protein 462 (ZNF462) gene variation or deletion of 9q31.2 involving ZNF462 and various congenital anomalies. Its specific clinical findings are abnormal facial shape, prominent forehead, high arched eyebrow, ptosis, delayed development of motor and language and mild global developmental delay. The prevalence of WSKA is only 25 individuals from literatures. Brain lesions related to WSKA are known as ventriculomegaly and middle line brain abnormalities like corpus callosum hypoplasia in about 25 percent of the patients. However, there have not been reported a patient who has structural malformation of pituitary gland with endocrine dysfunction. Here, we present a Korean boy molecularly confirmed as WSKA, having newly clinical manifestation of primary empty sella syndrome(ESS) associated with growth hormone deficiency(GHD). Case Presentation: A 16-year-old boy visited to our hospital presented with severe short stature and delayed puberty. He also complained mild hypotonia, congenital both ptosis, mild intellectual disability. In the anterior pituitary combined test, GHD was diagnosed. In the brain magnetic resonance image, ESS was showed. With starting and continuing recombinant human growth hormone replacement therapy, to identify the underlying genetic cause, chromosomal microarray analysis and whole exome sequencing test were conducted. Finally, a heterozygous novel frameshift variant, c.4185del(p.Met1396Ter) in ZNF462 confirmed by Sanger sequencing, which had not been reported was identified Conclusions: This is the first case of WSKA of an Asian with novel pathogenic variant of ZNF462 and new clinical features including primary ESS associated with GHD. This case could contribute to diagnosis of this syndrome, identify clinical features and provided novel insight into studies for the role of ZNF462 gene.

Intrasellar cyst masquerading as empty sella syndrome: history repeating itself

2019 ◽  
Author(s):  
Thomas Wright ◽  
Steven Tao ◽  
Joseph Harding ◽  
Sarah Chatharoo ◽  
Pankaj Chaturvedi ◽  
...  
Keyword(s):  
Empty Sella ◽  
Empty Sella Syndrome

The Empty Sella Syndrome

1968 ◽  
Vol 28 (4) ◽  
pp. 351-356 ◽  
Author(s):  
William M. Lee ◽  
John E. Adams
Keyword(s):  
Empty Sella ◽  
Empty Sella Syndrome

Metrizamide Computed Tomographic Cisternography for the Diagnosis of Occult Lesions of the Hypothalamic-Hypophyseal Axis in Children

Neurosurgery ◽  
1981 ◽  
Vol 8 (5) ◽  
pp. 531-541 ◽  
Author(s):  
Dachling Pang ◽  
Arthur E. Rosenbaum ◽  
James E. Wilberger ◽  
James P. Gutai
Keyword(s):  
Computed Tomography ◽  
Diagnostic Yield ◽  
Empty Sella ◽  
Functional Disorders ◽  
Ct Cisternography ◽  
Empty Sella Syndrome ◽  
Computed Tomographic ◽  
Suprasellar Cistern ◽  
Enhanced Computed Tomography ◽  
Metrizamide Ct Cisternography

Abstract In children, hypothalamic-hypophyseal syndromes such as diabetes insipidus, precocious puberty, growth retardation, and panhypopituitarism can be due either to structural lesions or to functional disorders of the cerebral endocrine complex. When clinical and endocrinological parameters fail to distinguish between these etiologies, neuroradiographical diagnosis becomes extremely important. Although conventional intravenously enhanced computed tomography (IVCT) is satisfactory for the diagnosis of lesions larger than 1 cm, metrizamide CT cisternography (MCTC) greatly improves the diagnostic yield for smaller juxtapituitary masses in the suprasellar cistern, clearly defines their sizes and relationships with contiguous structures, and definitively confirms the diagnosis of empty sella syndrome. Six patients with endocrinopathies and normal or ambiguous IVCT findings are presented to illustrate how MCTC can influence their management and outcome without the patient discomfort and technical complexity associated with pneumoencephalography.

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