Spontaneous intracranial hypotension (HIE) is an uncommon cause of secondary orthostatic headache, characterized by a decreased pressure and volume of cerebrospinal fluid (CSF), where dural quality and mechanical factors such as vertebral osteophytes play an important role, that after minimal trauma allow CSF leakage. We present the case of a 56-year-old male patient, who presented with severe postural headache, with a history of mild trauma at the level of the low thoracic spine with CSF pressure at the lower limit of normality, in whom radioisotopic SPECT/CT cisternography, provided the definitive diagnosis and exact anatomical location of the CSF leak, guiding treatment. A review of the pathophysiology, clinical presentation, diagnosis and treatment of HIE is carried out, emphasizing the diagnostic aid modalities, where hybrid imaging in nuclear medicine with SPECT/CT equipment allows a definitive diagnosis and management of HIE.