In memory of academician A.A. Vishnevsky – the chief surgeon of the Ministry of defense of the USSR (for the 45th anniversary of his death)

The life and work of academician Alexander Alexandrovich Vishnevsky are presented. During the Great Patriotic War, Alexander Alexandrovich served as an army surgeon and chief surgeon for a number of fronts. He became the director of the A.V. Vishnevsky of the USSR Academy of Medical Sciences in 1948 and later served as the chief surgeon of the USSR Ministry of Defense starting in 1956. As a student and the closest associate of his father A.V. Vishnevsky, Alexander Alexandrovich participated in the creation of a domestic surgical school and then became its leader after his fathers death. Analysis of the early works of Alexander Alexandrovich reveals his devotion to the anatomical substantiation of local anesthesia based on the method of creeping infiltrate. The well-known monograph Novocaine blockade and oil-balsamic antiseptics as a special type of pathogenetic therapy (1952), written by Alexander Alexandrovich and his father, is the result of many years of research on the role of nervous trophism in the pathogenesis of a number of surgical diseases. Alexander Alexandrovich also found that in the advanced stages of medical evacuation, surgical interventions on the wounded can be performed under local anesthesia by using the creeping infiltrate method. In peacetime, A.A. Vishnevsky continued to investigate the issues related to anesthesia and nervous trophism and collaborated with his colleagues to address a number of other pressing problems, including the surgery of the heart and blood vessels, mechanisms for compensating for impaired functions of organs and systems, the use of cybernetics and electronics in surgery, burn injuries, and the use of polymers in surgery. Moreover, A.A. Vishnevsky was the first surgeon in Russia to perform a successful open-heart surgery under the conditions of artificial circulation (1957). He was awarded the highest Ren Leriche International Prize for his work on local anesthesia during heart surgery (1955).

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Posttraumatic Growth following Open-heart Surgery: The Role of Religious Coping and the Underlying Mechanism

PsycEXTRA Dataset ◽

10.1037/e576422013-001 ◽

2013 ◽

Author(s):

Amy Ai

Keyword(s):

Posttraumatic Growth ◽

Religious Coping ◽

Heart Surgery ◽

Open Heart Surgery ◽

Underlying Mechanism ◽

Open Heart

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Intracardiac EUS-B-Guided FNA for Diagnosing Cardiac Tumors

Respiration ◽

10.1159/000516504 ◽

2021 ◽

pp. 1-5

Author(s):

Haizea Alvarez Martinez ◽

Jolanda C. Kuijvenhoven ◽

Jouke T. Annema

Keyword(s):

Left Atrium ◽

Heart Surgery ◽

Open Heart Surgery ◽

Needle Aspiration ◽

Invasive Technique ◽

Cardiac Tumors ◽

Surgical Interventions ◽

Tumor Diagnostics ◽

Specific Tumor ◽

Primary Cardiac Tumors

Primary cardiac tumors are extremely rare. Obtaining a tissue diagnosis is difficult and commonly requires open-heart surgery with associated morbidity. Esophageal endoscopic ultrasound (EUS) and EUS with the EBUS scope (EUS-B) provide real-time sampling of centrally located lung tumors and mediastinal lymph nodes. They also provide an excellent view of the left atrium, since it is located adjacent to the esophagus. To date, left atrium tumor diagnostics by endosonography is poorly explored. We describe 2 exceptional diagnostic cases of left atrium tumors in which cardiac surgery was hazardous due to the clinical condition or previous surgical interventions. During EUS-B-guided fine-needle aspiration (FNA), the left atrial masses were successfully and safely sampled, revealing a Burkitt lymphoma and a synovial sarcoma. FNA including cell block analysis enabled specific tumor diagnosis and molecular subtyping. Our findings suggest that in selected cases, linear endosonography qualifies as a minimally invasive technique for intracardiac tumor diagnostics.

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Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression

Journal of Clinical Medicine ◽

10.3390/jcm9010036 ◽

2019 ◽

Vol 9 (1) ◽

pp. 36

Author(s):

Laurence Jesel ◽

Malak Abbas ◽

Sin-Hee Park ◽

Kensuke Matsushita ◽

Michel Kindo ◽

...

Keyword(s):

Atrial Fibrillation ◽

Heart Surgery ◽

Open Heart Surgery ◽

Right Atrial ◽

Atrial Remodeling ◽

Inflammatory Proteins ◽

Underlying Mechanisms ◽

The Right ◽

New Evidence

Background: Whilst the link between aging and thrombogenicity in atrial fibrillation (AF) is well established, the cellular underlying mechanisms are unknown. In AF, the role of senescence in tissue remodeling and prothrombotic state remains unclear. Aims: We investigated the link between AF and senescence by comparing the expression of senescence markers (p53 and p16), with prothrombotic and inflammatory proteins in right atrial appendages from patients in AF and sinus rhythm (SR). Methods: The right atrial appendages of 147 patients undergoing open-heart surgery were harvested. Twenty-one non-valvular AF patients, including paroxysmal (PAF) or permanent AF (PmAF), were matched with 21 SR patients according to CHA2DS2-VASc score and treatment. Protein expression was assessed by tissue lysates Western blot analysis. Results: The expression of p53, p16, and tissue factor (TF) was significantly increased in AF compared to SR (0.91 ± 0.31 vs. 0.58 ± 0.31, p = 0.001; 0.76 ± 0.32 vs. 0.35 ± 0.18, p = 0.0001; 0.88 ± 0.32 vs. 0.68 ± 0.29, p = 0.045, respectively). Expression of endothelial NO synthase (eNOS) was lower in AF (0.25 ± 0.15 vs. 0.35 ± 0.12, p = 0.023). There was a stepwise increase of p53, p16, TF, matrix metalloproteinase-9, and an eNOS progressive decrease between SR, PAF, and PmAF. AF was the only predictive factor of p53 and p16 elevation in multivariate analysis. Conclusions: The study brought new evidence indicating that AF progression is strongly related to human atrial senescence burden and points at a link between senescence, thrombogenicity, endothelial dysfunction and atrial remodeling.

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