Сhronic gastritis: impaired motor-evacuation function of the stomach

2020 ◽  
Vol 22 (4) ◽  
pp. 37-42
Author(s):  
I. M. Pavlovich ◽  
G. A. Al’per ◽  
A. V. Gordienko ◽  
D. I. Proskunov ◽  
V. V. Yakovlev
Keyword(s):  
Atrophic Gastritis ◽  
Lower Esophageal Sphincter ◽  
Mucous Membrane ◽  
Motor Function ◽  
Morphological Changes ◽  
Duodenogastric Reflux ◽  
Chronic Atrophic Gastritis ◽  
Diffuse Atrophy ◽  
Esophageal Sphincter ◽  
Evacuation From The Stomach

The effect of morphological changes in the gastric mucosa on the motor-evacuation function of the stomach was evaluated in 90 patients with chronic atrophic gastritis and 93 patients with chronic non-atrophic gastritis aged 18 to 82 years. Motor function disturbances were discovered of 90% of patients with chronic atrophic gastritis and 80,6% with chronic non-atrophic gastritis. It was established that the pyloric insufficiency compared with its spasm was significantly more (p0,01) often in chronic atrophic gastritis. Insufficiency of the lower esophageal sphincter in patients with atrophic gastritis was significantly (p0,01). Insufficiency of the lower esophageal sphincter in combination with duodenogastric reflux in patients with chronic atrophic gastritis was significantly more (p0,01) often observed during diffuse atrophy, i. e. when mucous membrane of stomach corpus and antrum is involved in the process. With the localization of atrophy in the antrum alone, pyloric insufficiency was observed significantly more (p 0,01) often than spasm. Thus, an interrelation between the insufficiency of the lower esophageal and pyloric sphincters with the diffuse atrophic process has been established. There are no significant differences of disorders of gastric motor function in patients with different types of chronic gastritis. Accelerated evacuation from the stomach with localization of atrophy in the mucous membrane of the stomach corpus is more (p 0,01) often observed in patients with chronic atrophic gastritis.

scholarly journals Dynamics of inflammatory changes of the gastric mucosa in children with duodenal ulcer

2021 ◽  
Vol 16 (4) ◽  
pp. 285-288
Author(s):  
T.V. Sorokman ◽  
P.M. Moldovan ◽  
L.Yu. Khlunovska ◽  
I.Ya. Lozyuk
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Mucosa ◽  
Atrophic Gastritis ◽  
Mucous Membrane ◽  
Morphological Changes ◽  
Gastrointestinal Diseases ◽  
Chronic Atrophic Gastritis ◽  
Morphological Examination ◽  
Superficial Epithelium ◽  
Inflammatory Changes

Background. The problem of gastrointestinal diseases in children remains quite relevant due to the high prevalence and presence of atypical symptoms and comorbidities pathogenetically associated with acid-dependent diseases. The purpose was to study the dynamics of inflammatory changes of the mucous membrane in children with duodenal ulcer (DU). Materials and methods. One hundred and six children aged 10 to 18 years with DU were examined. To verify the diagnosis, all children underwent endoscopy, pH-metry, morphological examination of gastrobiopsy samples, examination for Helicobacter pylori (H.pylori). Results. 49.1 % of children with DU were diagnosed with impaired motor-evacuatory function in the form of duodenogastric and/or gastrooesophageal reflexes, 81.1 % of patients presented with H.pylori was determined. Erythematous changes of the gastric and duodenal mucosa predominated. 92.4 % of patients were diagnosed with chronic non-atrophic gastritis and/or gastroduodenitis with va­rying degrees of inflammation, 7.6 % of children — chronic atrophic gastritis. There was a decrease in height and signs of desquamation of the superficial epithelium, in 72.3 % — the development of granular dystrophy, in 6.9 % of patients without H.pylori infection and in 57.5 % of H.pylori infected — neutrophilic infiltration of the mucous membrane. In the dynamics after 3 months, the height of the superficial epithelium and the frequency of desquamative changes decreased, and the proliferation of the glandular epithelium 12.4 % increased. Conclusions. Morphological changes in biopsies of the gastric mucosa differ depending on the presence of H.pylori infection and partially persist for 3 months after treatment.

scholarly journals Chronic atrophic gastritis: risk factors and their correlation with morphological changes of gastric mucosa

2009 ◽  
Vol 53 (1) ◽  
pp. 14-20
Author(s):  
L.M. Mosiychuk ◽  
L.V. Demeshkina ◽  
I.V. Kushnirenko ◽  
O.V. Simonova ◽  
O.P. Petishko ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Mucosa ◽  
Atrophic Gastritis ◽  
Morphological Changes ◽  
Chronic Atrophic Gastritis

Does intragastric pH influence lower esophageal sphincter motor function?

2001 ◽  
Vol 120 (5) ◽  
pp. A223-A223
Author(s):  
M VERKIJK ◽  
A HERTOG ◽  
C LAMERS ◽  
A MASCLEE
Keyword(s):  
Lower Esophageal Sphincter ◽  
Motor Function ◽  
Intragastric Ph ◽  
Ph Influence ◽  
Esophageal Sphincter

Does intragastric pH influence lower esophageal sphincter motor function?

2001 ◽  
Vol 120 (5) ◽  
pp. A223
Author(s):  
M Verkijk ◽  
A.L. Hertog ◽  
C.B.H.W. Lamers ◽  
A.A.M. Masclee
Keyword(s):  
Lower Esophageal Sphincter ◽  
Motor Function ◽  
Intragastric Ph ◽  
Ph Influence ◽  
Esophageal Sphincter

scholarly journals Berberine Attenuates Chronic Atrophic Gastritis Induced by MNNG and Its Potential Mechanism

2021 ◽  
Vol 12 ◽  
Author(s):  
Yuling Tong ◽  
Liping Liu ◽  
Ruilin Wang ◽  
Tao Yang ◽  
Jianxia Wen ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Therapeutic Effect ◽  
Tissue Injury ◽  
Morphological Changes ◽  
Chronic Atrophic Gastritis ◽  
Signal Pathway ◽  
Cell Counting ◽  
Inflammatory Factors ◽  
Tgf Β1

The purpose of this study was to investigate the therapeutic effect of berberine (BBR) on MNNG-induced chronic atrophic gastritis (CAG) and the possible mechanism of BBR through TGF-β1/PI3K signal pathway. GES-1 were pretreated with MNNG for 2 h before BBR treatment in all procedures. Cell viability was quantified by cell counting kit-8, and GES-1 morphology and proliferation were detected by high content screening (HCS) assay. The rat model of CAG was established by MNNG, and the therapeutic effect of BBR on stomach histopathology and serum supernatant were analyzed in vivo. In addition, the possible mechanism of BBR was further discussed, and the expression of related genes and proteins in TGF-β1/PI3K signal pathway was detected. The results showed that BBR could significantly improve the survival rate and morphological changes of GES-1, improve the gastric tissue injury of CAG rats, and reduce the expression of G-17 and inflammatory factors IL-8, TNF-α, IL-6 and IL-1β. In addition, BBR down-regulated the expression of TGF-β1 axis-related signals such as TGF-β1, PI3K, p-Akt/Akt, p-mTOR/mTOR and P70S6K, and promoted the expression of PTEN, LC3-II and Beclin-1. In Conclusion, BBR can improve CAG which may be closely related to TGF-β1/PI3K signal pathway.

Characterization of esophageal body and lower esophageal sphincter motor function in the very premature neonate

1999 ◽  
Vol 135 (4) ◽  
pp. 517-521 ◽  
Author(s):  
Taher I. Omari ◽  
Marc A. Benninga ◽  
Christopher P. Barnett ◽  
Ross R. Haslam ◽  
Geoff P. Davidson ◽  
...  
Keyword(s):  
Lower Esophageal Sphincter ◽  
Motor Function ◽  
Premature Neonate ◽  
Esophageal Body ◽  
Esophageal Sphincter

Effect of prolonged gastric distension on motor function of LES and of proximal stomach

2002 ◽  
Vol 283 (3) ◽  
pp. G677-G680 ◽  
Author(s):  
M. Allocca ◽  
M. Mangano ◽  
R. Penagini
Keyword(s):  
Lower Esophageal Sphincter ◽  
Motor Function ◽  
Healthy Subjects ◽  
Time Effect ◽  
Gastric Distension ◽  
Threshold Pressure ◽  
Proximal Stomach ◽  
Experimental Conditions ◽  
Esophageal Sphincter ◽  
Sensory Functions

Gastric distension is a potent stimulus of transient lower esophageal sphincter (LES) relaxation. To investigate the time effect of prolonged gastric distension on the rate of transient LES relaxations, LES pressure, and the motor and sensory functions of the proximal stomach, we performed a continuous isobaric distension of the proximal stomach at the 75% threshold pressure for discomfort for 2 h in seven healthy subjects. A multilumen assembly incorporating a sleeve and an electronic barostat was used. The rate of transient LES relaxations ( n/30 min) was constant during the first hour [4.1 ± 1.2 (0–30 min) and 5.4 ± 1.1 (30–60 min)] but markedly decreased ( P < 0.05) in the second hour [2.1 ± 0.5 (60–90 min) and 2.3 ± 0.9 (90–120 min)], whereas LES pressure, baseline volume and volume waves within the gastric bag, hunger, and fullness did not change throughout the experiment. It is concluded that the rate of transient LES relaxations decreases with time during prolonged gastric distension, thus suggesting that this type of stimulus should not be used in sequential experimental conditions.

Motor function of the esophagus and the lower esophageal sphincter in children who undergo laparoscopic Nissen fundoplication

2000 ◽  
Vol 35 (11) ◽  
pp. 1666-1671 ◽  
Author(s):  
Hisayoshi Kawahara ◽  
Kenji Imura ◽  
Kiyokazu Nakajima ◽  
Makoto Yagi ◽  
Shinkichi Kamata ◽  
...  
Keyword(s):  
Lower Esophageal Sphincter ◽  
Motor Function ◽  
Nissen Fundoplication ◽  
Laparoscopic Nissen Fundoplication ◽  
Esophageal Sphincter ◽  
Laparoscopic Nissen

Effect of dopamine on esophageal motor function.

1977 ◽  
Vol 232 (1) ◽  
pp. E19 ◽  
Author(s):  
A K Mukhopadhyay ◽  
N Weisbrodt
Keyword(s):  
Dopamine Receptors ◽  
Lower Esophageal Sphincter ◽  
Motor Function ◽  
Intravenous Administration ◽  
Physiological Role ◽  
Lower Esophageal Sphincter Pressure ◽  
The Body ◽  
Sphincter Pressure ◽  
Esophageal Sphincter ◽  
Dose Dependent

Intravenous administration of dopamine produced a dose-dependent decrease in lower esophageal sphincter pressure and a dose dependent increase in contractile activity of the body of the esophagus. The threshold dose of dopamine was 0.25 mug/kg, and the effect reached a plateau at about 6 mug/kg. A dose of 6 mug/kg of dopamine produced 83%+/-3 (SE) reduction in the lower esophageal sphincter pressure and 12+/-1 (SE) contractions in the body of the esophagus within 5 min of the bolus injection. Atropine, phentolamine, propranolol, and bilateral cervical vagotomy did not modify the effect of dopamine. Both haloperidol and bulbocapnine potently antagonized the effect of dopamine. The amplitude of esophageal contraction in the lower esophagus in response to pharyngeal stimulation and esiogageal distention was significantly increased after administration of haloperidol. It is concluded that intravenous administration of dopamine has potent effects on the motor function of the lower esophageal sphincter and the body of the esophagus. The effect of dopamine is not mediated via the vagal centers in the brain or cholinergic muscarinic and adrenergic receptors. The response of the smooth muscle segment of opossum esophagus to intravenous dopamine is mediated via specific dopamine receptors. The inhibitory dopamine receptors may play a physiological role in controlling the amplitude of esophageal contractions.

Sign in / Sign up

Export Citation Format

Share Document