scholarly journals REGENERATIVE REHABILITATION OF SKELETAL MUSCLES DAMAGES

2021 ◽  
Author(s):  
Alexandr S. Golota ◽  
Sergey G. Sherbak ◽  
Stanislav V. Makarenko ◽  
Andrey M. Sarana ◽  
Tatyana A. Kamilova
Keyword(s):  
Patient Outcomes ◽  
Skeletal Muscles ◽  
Genetic Basis ◽  
Molecular Genetic ◽  
Scientific Research ◽  
Expression Levels ◽  
Rehabilitation Programs ◽  
Current State ◽  
Molecular Genetic Basis ◽  
Improve Patient

The article is devoted to the analysis of the current state of regenerative and rehabilitative treatments of skeletal muscles, the possibilities of restoring the functioning of tissue lost due to aging, injuries or diseases. The study of the molecular genetic basis of mechanotransduction and mechanotherapy will allow the identification of genes and molecules, the expression levels of which can serve as biomarkers of the effectiveness of regenerative-rehabilitation measures. These mechanisms are potential therapeutic targets for stimulating of regeneration of skeletal muscles. The focus of the article is on the choice of an individual approach, both when conducting basic scientific research and developing rehabilitation programs. All this will significantly improve patient outcomes.

scholarly journals Regenerative Rehabilitation for Bone Tissue Damage

2021 ◽  
Vol 3 (1) ◽  
pp. 48-62
Author(s):  
Alexander S. Golota ◽  
Stanislav V. Makarenko ◽  
Sergey G. Sсherbak ◽  
Tatyana A. Kamilova
Keyword(s):  
Patient Outcomes ◽  
Tissue Damage ◽  
Genetic Basis ◽  
Special Section ◽  
Molecular Genetic ◽  
Rehabilitation Programs ◽  
Current State ◽  
Molecular Genetic Basis ◽  
Rehabilitation Measures ◽  
Improve Patient

The article is devoted to the analysis of the current state of regenerative and rehabilitative treatments in orthopedics, the possibilities of restoring of bone lost due to injuries or diseases. An overview of the main methods and approaches to enable effective regenerative and rehabilitation measures is given. The study of the molecular genetic basis of mechanotransduction and mechanotherapy will allow the identification of genes and molecules, the expression levels of which can serve as biomarkers of the effectiveness of regenerative-rehabilitation measures. These mechanisms are potential therapeutic targets for stimulating of regeneration of bones. A special section is devoted to the study of the characteristics of cellular technologies in the treatment of injuries and diseases of these tissues. The focus of the article is on the choice of an individual approach, both when conducting basic scientific research and developing rehabilitation programs. All this will significantly improve patient outcomes.

Regenerative rehabilitation in injuries of cartilaginous tissue (review)

MedAlliance ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 40-49
Keyword(s):  
Patient Outcomes ◽  
Genetic Basis ◽  
Molecular Genetic ◽  
Cartilage Regeneration ◽  
Review Article ◽  
Cartilaginous Tissue ◽  
Expression Levels ◽  
Individual Approach ◽  
Molecular Genetic Basis ◽  
Improve Patient

SummaryThe review article is devoted to the analysis of the cur-rent state of regenerative and rehabilitative treatments in orthopedics, the possibilities of restoring the func-tioning of cartilaginous tissue lost due to aging, inju-ries or di seases. An overview of the main methods and approaches to enable effective regenerative and reha-bilitation measures is given. The study of the molecular genetic basis of mechanotransduction and mechano-therapy will allow to identify genes and molecules, the expression levels of which can serve as biomarkers of the effectiveness of regenerative-rehabilitation measures. These mechanisms are potential therapeutic targets for stimulating cartilage regeneration. The focus of the arti-cle is on the choice of an individual approach, both when conducting basic scien tific research and developing re-habilitation programs. All this will significantly improve patient outcomes.

scholarly journals The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome

2005 ◽  
Vol 26 (2) ◽  
pp. 251-282 ◽  
Author(s):  
Héctor F. Escobar-Morreale ◽  
Manuel Luque-Ramírez ◽  
José L. San Millán
Keyword(s):  
Environmental Factors ◽  
Polycystic Ovary Syndrome ◽  
Diagnostic Criteria ◽  
Genetic Basis ◽  
Polycystic Ovary ◽  
Molecular Genetic ◽  
Ovary Syndrome ◽  
The Metabolic Syndrome ◽  
Molecular Genetic Basis ◽  
Functional Hyperandrogenism

The genetic mechanisms underlying functional hyperandrogenism and the polycystic ovary syndrome (PCOS) remain largely unknown. Given the large number of genetic variants found in association with these disorders, the emerging picture is that of a complex multigenic trait in which environmental influences play an important role in the expression of the hyperandrogenic phenotype. Among others, genomic variants in genes related to the regulation of androgen biosynthesis and function, insulin resistance, and the metabolic syndrome, and proinflammatory genotypes may be involved in the genetic predisposition to functional hyperandrogenism and PCOS. The elucidation of the molecular genetic basis of these disorders has been burdened by the heterogeneity in the diagnostic criteria used to define PCOS, the limited sample size of the studies conducted to date, and the lack of precision in the identification of ethnic and environmental factors that trigger the development of hyperandrogenic disorders. Progress in this area requires adequately sized multicenter collaborative studies after standardization of the diagnostic criteria used to classify hyperandrogenic patients, in whom modifying environmental factors such as ethnicity, diet, and lifestyle are identified with precision. In addition to classic molecular genetic techniques such as linkage analysis in the form of a whole-genome scan and large case-control studies, promising genomic and proteomic approaches will be paramount to our understanding of the pathogenesis of functional hyperandrogenism and PCOS, allowing a more precise prevention, diagnosis, and treatment of these prevalent disorders.

scholarly journals A Molecular Genetic Basis Explaining Altered Bacterial Behavior in Space

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0164359 ◽  
Author(s):  
Luis Zea ◽  
Nripesh Prasad ◽  
Shawn E. Levy ◽  
Louis Stodieck ◽  
Angela Jones ◽  
...  
Keyword(s):  
Genetic Basis ◽  
Molecular Genetic ◽  
Molecular Genetic Basis

Clinical and genetic parallels of the classification and diagnosis of Ehlers-Danlos syndrome

2021 ◽  
pp. 14-26
Author(s):  
Д.Д. Надыршина ◽  
А.В. Тюрин ◽  
Э.К. Хуснутдинова ◽  
Р.И. Хусаинова
Keyword(s):  
Genetic Counseling ◽  
Family Medicine ◽  
Genetic Basis ◽  
Molecular Genetic ◽  
Hereditary Disease ◽  
Orphan Diseases ◽  
Ehlers Danlos Syndrome ◽  
General Medical Practice ◽  
Molecular Genetic Basis ◽  
Danlos Syndrome

Статья посвящена обсуждению подходов к классификации и обзору доступных литературных данных о клинической вариабельности и молекулярно-генетических основах патогенеза редкого наследственного заболевания - синдрома Элерса-Данло. Представленный обзор расширит представление о патогенезе и позволит оптимизировать диагностику данного синдрома, определить тактику лечения и медико-генетического консультирования отягощенных семей как клиническим генетикам, специалистам в области изучения орфанных заболеваний, так и врачам терапевтам, специалистам семейной медицины и общей врачебной практики. The article is devoted to the discussion of approaches to the classification and review of the available literature data on clinical variability and the molecular genetic basis of the pathogenesis of a rare hereditary disease - Ehlers-Danlos syndrome. The presented review will expand the understanding of the pathogenesis and allow to optimize the diagnosis of this syndrome, to determine the tactics of treatment and medical and genetic counseling of burdened families, both to clinical geneticists, specialists in the study of orphan diseases, and to general practitioners, specialists in family medicine and general medical practice.

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