HUMAN PAPILLOMAVIRUS AS AN EPIGENETIC COFACTOR OF THE DEVELOPMENT OF SEVERAL EPITHELIAL NON-MELANOCYTIC SKIN NEOPLASMS (LITERATURE REVIEW)

In recent decades, interest in the role of human papillomavirus (HPV) has been steadily increasing, which can be attributed both to the evolution of molecular genetic detection methods and to the widespread of this viral infection in the population. Epidemiological and molecular biological data suggest that HPV genus beta can cause the development of a number of epithelial non-melanocytic neoplasms of the skin. However, this relationship has not yet been fully studied. Possibly, human papillomavirus infection should be considered from the perspective of co-carcinogenesis with the cumulative effect of UV irradiation, which is indirectly indicated by the predominant localization of elements in open areas of the skin and the high risks of their malignant transformation.