The macrophage activation marker, soluble CD163 is associated with hepatic inflammation and fibrosis in chronic viral hepatitis C and declines during effective direct-acting antiviral therapy

2017 ◽  
Vol 66 (1) ◽  
pp. S742
Author(s):  
T.L. Laursen ◽  
C. Siggaard ◽  
K. Kazankov ◽  
T. Sandahl ◽  
H.J. Møller ◽  
...  

Long-term efficacy of direct-acting antiviral drugs (DAAD) was evaluated in 44 patients with chronic viral hepatitis C who had been receiving therapy at the Khabarovsk and Kamchatka centers for the prevention and control of AIDS and infectious diseases from 2015 to 2018. The data were evaluated through a retrospective analysis of ambulatory patient records and control in the form of a qualitative detection of viral RNA by a highly sensitive PCR method. According to the results of the analysis, 41 out of 44 patients (93,18 %) managed to achieve a stable virological response (SVR 24), which remains stable at present (p<0,05). Three of the studied patients had a relapse, probably associated with incorrect treatment regimens and the presence of cogenotypes. The data obtained indicate a high efficiency of DAAD in the treatment of chronic viral hepatitis C in the Khabarovsk and Kamchatka territories.


2019 ◽  
Vol 09 (07) ◽  
pp. 125-133
Author(s):  
Laté Mawuli Lawson-Ananissoh ◽  
Aklesso Bagny ◽  
Oumboma Bouglouga ◽  
Laconi Kaaga ◽  
Rafiou El-Hadji Yakoubou ◽  
...  

2016 ◽  
Vol 2 (2) ◽  
pp. 59-68
Author(s):  
Anca Streinu-Cercel ◽  
Maria-Magdalena Moțoi ◽  
Alina Cristina Neguț ◽  
Luminița Bradu ◽  
Daniela Manolache ◽  
...  

2018 ◽  
Vol 35 (4) ◽  
pp. 661-666 ◽  
Author(s):  
Cristina Stasi ◽  
Caterina Silvestri ◽  
Roberto Berni ◽  
Maurizia Rossana Brunetto ◽  
Anna Linda Zignego ◽  
...  

Author(s):  
T. Ye. Makarova ◽  
◽  
N.N. Dudareva ◽  
N.N. Poletaeva ◽  
E.A. Medvedeva ◽  
...  

The problem of chronic viral hepatitis C currently remains relevant due to the high incidence, frequent outcomes in liver cirrhosis, high disability of the population, and expensive treatment. The article discusses timely approaches to the treatment of chronic viral hepatitis C, using interferon-free therapy regimens.


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