Long-term efficacy of direct-acting antiviral drugs (DAAD) was evaluated in 44 patients with chronic viral hepatitis C who had been receiving therapy at the Khabarovsk and Kamchatka centers for the prevention and control of AIDS and infectious diseases from 2015 to 2018. The data were evaluated through a retrospective analysis of ambulatory patient records and control in the form of a qualitative detection of viral RNA by a highly sensitive PCR method. According to the results of the analysis, 41 out of 44 patients (93,18 %) managed to achieve a stable virological response (SVR 24), which remains stable at present (p<0,05). Three of the studied patients had a relapse, probably associated with incorrect treatment regimens and the presence of cogenotypes. The data obtained indicate a high efficiency of DAAD in the treatment of chronic viral hepatitis C in the Khabarovsk and Kamchatka territories.