scholarly journals The role of bacterial biofilms in the development of chronic pathological processes in the vagina and endometrium

2016 ◽  
Vol 65 (4) ◽  
pp. 65-75 ◽  
Author(s):  
Kira V. Shalepo ◽  
Tatiana G. Mihailenko ◽  
Alevtina M. Savicheva
Keyword(s):  
Pregnancy Outcomes ◽  
Biofilm Formation ◽  
Anaerobic Bacteria ◽  
Bacterial Biofilms ◽  
Vitro Fertilization ◽  
Microbial Biofilms ◽  
Ascending Infection ◽  
Adverse Pregnancy

Microbial biofilms are a problem in many areas of medicine. When the vaginal ecological system is disturbed, well-structured polymicrobial biofilm, covering the vaginal epithelium and consisting of anaerobic bacteria, is formed, which may lead to the development of recurrent bacterial vaginosis. During an ascending infection and the development of chronic endometritis, bacterial biofilms are detected in the endometrium. Biofilms formed by bacteria residing in the urogenital tract of woman, may result in dysfunctions of the reproductive system, in-vitro fertilization failures, complications of pregnancy, adverse pregnancy outcomes. In the paper, literature data regarding causes of of biofilm formation, methods of detection and treatment of biofilm infections are reviewed.

The scattered puzzle effect: implantation disorders in chronic endometritis

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (6) ◽  
pp. 93-100
Author(s):  
Victor E. Radzinsky ◽  
Mekan R. Orazov ◽  
Liliia R. Toktar ◽  
Liudmila M. Mihaleva ◽  
Pavel A. Semenov ◽  
...  
Keyword(s):  
Uterine Cavity ◽  
Special Role ◽  
Inadequate Response ◽  
Chronic Endometritis ◽  
Vitro Fertilization ◽  
Endometrial Cells ◽  
Adverse Pregnancy ◽  
Relationship Of

Chronic endometritis (CE) is defined as a state of inflammation localized in the endometrium, accompanied by edema, dissociated maturation of epithelial cells and fibroblasts, increased stromal density and the presence of plasma cell infiltrate in it. The connection between chronic inflammation in the endometrium and infertility deserves special attention. Inadequate response of immunocompetent endometrial cells, including impaired synthesis of proinflammatory cytokines, dysreceptiveness, disorders of proliferation and differentiation processes are the main links in the formation of infertility in patients with CE. Despite the fact that the presence of a normocenosis of the uterine cavity today is not in doubt this is a physiological norm, persistent bacterial infection of the endometrium is still called the main etiopathogenetic factor of CE and, therefore, the main point of application of therapeutic agents. Nevertheless, a number of works have emphasized the special role of not bacterial, but viral etiology of endometritis, especially in the context of infertility developing against this background. It seems that the role of viral endometrial infection in adverse pregnancy outcomes and in vitro fertilization programs is underestimated. Further research is needed to clarify the relationship of viral infection as a trigger of implantation failure in infertile women with CE.

scholarly journals Adverse pregnancy outcomes after in vitro fertilization: effect of number of embryos transferred and plurality at conception

2015 ◽  
Vol 104 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Barbara Luke ◽  
Judy E. Stern ◽  
Milton Kotelchuck ◽  
Eugene R. Declercq ◽  
Mark D. Hornstein ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Vitro Fertilization ◽  
Fertilization Effect ◽  
Adverse Pregnancy

scholarly journals Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans

Open Biology ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 160109 ◽  
Author(s):  
Paul Laissue ◽  
Besma Lakhal ◽  
Magalie Vatin ◽  
Frank Batista ◽  
Gaëtan Burgio ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Quantitative Traits ◽  
High Rate ◽  
Sequencing Analysis ◽  
Mus Spretus ◽  
Recombinant Congenic Strain ◽  
Dna Fragment ◽  
Adverse Pregnancy

Recurrent spontaneous abortion (RSA) is a common cause of infertility, but previous attempts at identifying RSA causative genes have been relatively unsuccessful. Such failure to describe RSA aetiological genes might be explained by the fact that reproductive phenotypes should be considered as quantitative traits resulting from the intricate interaction of numerous genetic, epigenetic and environmental factors. Here, we studied an interspecific recombinant congenic strain (IRCS) of Mus musculus from the C57BL6/J strain of mice harbouring an approximate 5 Mb DNA fragment from chromosome 13 from Mus spretus mice (66H-MMU13 strain), with a high rate of embryonic resorption (ER). Transcriptome analyses of endometrial and placental tissues from these mice showed a deregulation of many genes associated with the coagulation and inflammatory response pathways. Bioinformatics approaches led us to select Foxd1 as a candidate gene potentially related to ER and RSA. Sequencing analysis of Foxd1 in the 66H-MMU13 strain, and in 556 women affected by RSA and 271 controls revealed non-synonymous sequence variants. In vitro assays revealed that some led to perturbations in FOXD1 transactivation properties on promoters of genes having key roles during implantation/placentation, suggesting a role of this gene in mammalian implantation processes.

1019 Twin gestations conceived via in vitro fertilization are associated with increased adverse pregnancy outcomes

2021 ◽  
Vol 224 (2) ◽  
pp. S631
Author(s):  
Moti Gulersen ◽  
Yael Eliner ◽  
Amos Grunebaum ◽  
Erez Lenchner ◽  
Liron Bar-El ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Vitro Fertilization ◽  
Adverse Pregnancy
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