scholarly journals The state of hemostasis in perimenopause and hormonal replacement therapy

2021 ◽  
Vol 50 (1) ◽  
pp. 74-79
Author(s):  
M. A. Repin
Keyword(s):  
Replacement Therapy ◽  
The State ◽  
Hormonal Replacement Therapy ◽  
Hormonal Replacement

The interruption in the ovarianfunctioning goes along with the disturbances of vascular-trombocyte hemostasis: intravascular trombocyte activation increases, trombocyte micro- and macro-aggregates appear. Cyclic hormonal replacement therapy with Femoston, which contains estradiol and didrogesterone, helps to normalize the trombocytogram. Besides that, the addition of progestagen didrogesterone increases the effect of estradiol on micro circular hemostasia.

scholarly journals Menarche in primary ovarian insufficiency after a month of hormone replacement therapy: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Biwen Cheng
Keyword(s):  
Replacement Therapy ◽  
Hormone Replacement ◽  
Estrogen Therapy ◽  
Primary Ovarian Insufficiency ◽  
Hormonal Replacement Therapy ◽  
Delayed Puberty ◽  
Ovarian Insufficiency ◽  
Breakthrough Bleeding ◽  
Hormonal Replacement ◽  
Ovarian Dysgenesis

Abstract Background Gynecologic anomalies, including uterine agenesis and ovarian dysgenesis, are some of the several differential diagnoses in adolescent females with primary amenorrhea and delayed puberty. Primary ovarian insufficiency is reported in the clinical practice of reproductive endocrinology can be determined by conducting sex hormone tests to evaluate the hypothalamic-pituitary-ovarian axis. However, confirmation of Mullerian agenesis by image modalities can be extremely challenging. Once the diagnosis is established, breakthrough bleeding usually occurs 2 to 3 years after hormonal replacement therapy. Case presentation We report a case of a seventeen year old Taiwanese female, 46 XX karyotype, with ovarian dysgenesis and an initial tentative diagnosis of uterine agenesis who experienced a breakthrough bleeding after a month of hormonal replacement therapy. Conclusions The breakthrough bleeding after a month of estrogen therapy in primary ovarian insufficiency is uncommon, and the diagnosis of the absent uterus can have an extensive psychological impact on patients and their families.

scholarly journals HORMONAL REPLACEMENT THERAPY MODULATES THE EXPRESSION OF Nrf2 AND THE ACTIVITY OF ANTIOXIDANT ENZYMES IN VASCULAR ORGANS IN A MODEL OF OVARIECTOMY

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO4-2-46
Author(s):  
Lourdes G. Baeza-Perez ◽  
Claudia Calzada-Mendoza ◽  
Maria Elena Hernandez-Campos ◽  
Pedro Lopez-Sanchez ◽  
Liliana Anguiano-Robledo
Keyword(s):  
Antioxidant Enzymes ◽  
Replacement Therapy ◽  
Hormonal Replacement Therapy ◽  
Hormonal Replacement
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