The value of the anterior pituitary gland in gynecology

Removal of the anterior pituitary gland in infantile animals leads to a cessation of the development of the gonads and growth, as well as to a number of metabolic changes. As shown by relevant studies, the anterior lobe of the pituitary gland produces a hormone that gives a powerful impulse to the sex glands and causes all the phenomena of early puberty in infantile animals for several days.

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Discovery of the luteinizing hormone of the anterior pituitary gland

AJP Endocrinology and Metabolism ◽

10.1152/classicessays.00006.2004 ◽

2004 ◽

Vol 287 (5) ◽

pp. E818-E819 ◽

Cited By ~ 3

Author(s):

H. Maurice Goodman

Keyword(s):

Luteinizing Hormone ◽

Pituitary Gland ◽

Anterior Pituitary ◽

Anterior Lobe ◽

Anterior Pituitary Gland ◽

Luteinizing Hormones ◽

Historical Significance ◽

Classic Paper

This essay looks at the historical significance of an APS classic paper that is freely available online: Fevold HL, Hisaw FL, Leonard SL. The gonad stimulating and the luteinizing hormones of the anterior lobe of the hypophesis. Am J Physiol 97: 291—301, 1931 ( http://ajplegacy.physiology.org/cgi/reprint/97/2/291 ).

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Diabetes and Hypercholesterolemia Impair the Cytological Structure of the Anterior Pituitary Gland

Biosciences Biotechnology Research Asia ◽

10.13005/bbra/2780 ◽

2019 ◽

Vol 16 (3) ◽

pp. 649-658

Author(s):

Ahmed MR Abdo ◽

Mohamed E El-Beeh ◽

Sameer H. Qari ◽

Dina A El-badry ◽

Hassan IH El-Sayyad

Keyword(s):

Body Weight ◽

Pituitary Gland ◽

Anterior Pituitary ◽

Secretory Granules ◽

Reproductive Function ◽

Anterior Lobe ◽

Anterior Pituitary Gland ◽

Albino Rats ◽

Pituitary Glands ◽

Cytological Picture

Increase consumption of high fat diet was found to alter blood sugar level similar to diabetes and contributed to the development of obesity and affected the reproductive function of both sexes. The study aimed to clarify the influence of diabetes and or hypercholesterolemia on the cytological picture of cells of the anterior lobe of pituitary gland of male albino rats. Eighteen male albino rats weighing approximately 120 gram body weight were divided into three main groups; control, diabetes, hypercholesterolemia, diabetes (single i.p. 40 mg streptozotocin/kg B.wt plus 100mg. nicotinamide /kg body weight) and hypercholesterolemia (diet containing 3% cholesterol). Dietary feeding on cholesterol and diabetes were carried out for 12 weeks. At the end of treatment, animals were sacrificed, and pituitary glands were separated and their anterior lobe was processed for cytological investigations by transmission electron microscopy. The present study revealed that the rats subjected to experimental diabetes and/ or hypercholesterolemia exhibited a decrease of the secretory granules within the gonadotroph cells somatotroph and corticotrophin cells. There was a detected intracellular accumulation of fat globules in both the gonado- and sommatotroph cells. The authors reported that the altered cytological structures of the secretory function of the anterior pituitary gland led to marked impairment of the male hormonal level and causing infertility.

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THE REPAIR OF POST-PARTUM NECROSIS OF THE ANTERIOR LOBE OF THE PITUITARY GLAND

Acta Endocrinologica ◽

10.1530/acta.0.0480040 ◽

1965 ◽

Vol 48 (1) ◽

pp. 40-60 ◽

Cited By ~ 12

Author(s):

H. L. Sheehan

Keyword(s):

Pituitary Gland ◽

Anterior Pituitary ◽

Post Partum ◽

Anterior Lobe ◽

Anterior Pituitary Gland ◽

The Other ◽

Histological Changes ◽

Maximum Capacity ◽

Narrow Layer ◽

Marginal Zones

ABSTRACT The healing of a post-partum necrosis of the anterior pituitary gland begins at about 4 days. The first change is the formation of a narrow layer of secondary atrophy at the inner edge of the live margin zone. There is then an invasion of macrophages which clear the debris from the other marginal zones and finally penetrate to a depth of 1 to 1.5 mm into the infarct. The remaining part of the central dead area becomes condensed and hyalinised in the course of the subsequent year or two. In the healed stage the remnants of parenchyma must certainly be functioning to their maximum capacity but they do not show any very striking histological changes to correspond to this. The cellular pattern of these remnants can not be correlated with variations in the clinical or pathological picture of prolonged hypopituitarism.

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STUDIES ON THE GROWTH AND HORMONE PRODUCTION OF RAT HYPOPHYSIS IN TISSUE CULTURE

Acta Endocrinologica ◽

10.1530/acta.0.0430147 ◽

1963 ◽

Vol 43 (1) ◽

pp. 147-154 ◽

Cited By ~ 2

Author(s):

Stig Kullander

Keyword(s):

Tissue Culture ◽

Pituitary Gland ◽

Anterior Pituitary ◽

Anterior Lobe ◽

Anterior Pituitary Gland ◽

The Other ◽

Pituitary Tumours ◽

Hormone Production ◽

Other Hand

ABSTRACT The anterior lobe of the pituitary gland of the rat was studied in tissue culture. Oestrone, progesterone and androsterone did not have any effect on the growth. On the other hand, oestrogen-induced pituitary tumours in tissue culture grew more quickly in medium containing oestrone or androsterone. The anterior pituitary gland produced prolactin in vitro.

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The mitogenic effects of corticotrophin-releasing factor on the anterior pituitary gland of the rat

Journal of Endocrinology ◽

10.1677/joe.0.1180237 ◽

1988 ◽

Vol 118 (2) ◽

pp. 237-NP ◽

Cited By ~ 32

Author(s):

A. M. McNicol ◽

M. A. G. Kubba ◽

E. McTeague

Keyword(s):

Pituitary Gland ◽

Anterior Pituitary ◽

Volume Density ◽

Anterior Lobe ◽

Anterior Pituitary Gland ◽

Sprague Dawley ◽

Measurement Volume ◽

Corticotrophin Releasing Factor ◽

Sprague Dawley Rats ◽

Related Increase

ABSTRACT The immunohistochemically defined corticotroph population in the anterior pituitary gland of the adult male Sprague–Dawley rat has been quantified at 2 and 6 weeks after bilateral adrenalectomy using the stereological measurement, volume density (Vv). An approximately twofold increase in corticotroph Vv was demonstrated at 2 weeks in adrenalectomized rats compared with that in sham-operated controls and this was maintained at 6 weeks. Daily i.p. injections of ovine corticotrophin-releasing factor (CRF-41) induced a significant dose-related increase in corticotroph Vv when administered at doses of 25 and 50 μg/kg body weight, but this was less than the increase following adrenalectomy. Assessment of changes in mitotic activity of the total anterior lobe of adult Sprague–Dawley rats and of the corticotroph population was also made after daily i.p. injections of 50 μg CRF-41/kg for 2 and 7 days. There was no increase in overall mitotic index at either time. However, the numbers of mitotic corticotrophs were significantly increased in CRF-injected animals compared with those in saline-injected rats. These results indicate a role for CRF-41 in the regulation of corticotroph growth. J. Endocr. (1988) 118, 237–241

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