Effect of dimethyl sulfoxide applications on gastric secretory function

1982 ◽  
Vol 63 (3) ◽  
pp. 24-25
Author(s):  
S. G. Vaynshteyn ◽  
Yu. V. Afanasyeva ◽  
D. H. Maksudova ◽  
M. I. Pivikova
Keyword(s):  
Gastric Mucosa ◽  
Acid Secretion ◽  
Dimethyl Sulfoxide ◽  
Chronic Gastritis ◽  
Secretory Function ◽  
Normal Acid

The use of applications of dimethyl sulfoxide in patients with ulcerative disease and chronic gastritis leads to suppression of increased acid secretion, ambivalence with normal acid secretion and has no effect in patients with atrophy of the gastric mucosa. The normalizing effect of dimethyl sulfoxide (DMSO) applications in persons with acidic, decompensated ^ and subcompensated states of the stomach by stimulating the neutralizing function of the antral glands was established. The use of dimethyl sulfoxide as a transporter of various drugs in physiotherapy can be indicated in patients with HC1 hypersecretion in the interdigestive phase of ventricular secretion.

The study on the ultrastructure of gastric mucosa and secretory function in chronic gastritis

1970 ◽  
Vol 5 (1) ◽  
pp. 84-85
Author(s):  
S. Yamagata ◽  
A. Ishimori ◽  
H. Sakurada ◽  
J. Yamagata ◽  
A. Kano
Keyword(s):  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Secretory Function

Expression of NKCC1 and NKCC2 in gastric mucosa and their possible role in acid secretion

2010 ◽  
Vol 34 (8) ◽  
pp. S2-S2
Author(s):  
Tuo Ji ◽  
Hong Xue ◽  
Zhangfeng Dou ◽  
Yue Zhang ◽  
Jinxia Zhu
Keyword(s):  
Gastric Mucosa ◽  
Acid Secretion

scholarly journals Relation of Helicobacter pylori to the human gastric mucosa in chronic gastritis of the antrum.

Gut ◽  
1990 ◽  
Vol 31 (11) ◽  
pp. 1230-1236 ◽  
Author(s):  
L L Thomsen ◽  
J B Gavin ◽  
C Tasman-Jones
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Human Gastric Mucosa

Nitric oxide inhibits gastric acid secretion by increasing intraparietal cell levels of cGMP in isolated human gastric glands

2005 ◽  
Vol 289 (6) ◽  
pp. G1061-G1066 ◽  
Author(s):  
Anna Berg ◽  
Stefan Redéen ◽  
Magnus Grenegård ◽  
Ann-Charlott Ericson ◽  
Sven Erik Sjöstrand
Keyword(s):  
Nitric Oxide ◽  
Gastric Mucosa ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Enzymatic Digestion ◽  
Human Gastric Mucosa ◽  
Gastric Glands ◽  
Oxyntic Mucosa ◽  
No Donor

We have previously identified cells containing the enzyme nitric oxide (NO) synthase (NOS) in the human gastric mucosa. Moreover, we have demonstrated that endogenous and exogenous NO has been shown to decrease histamine-stimulated acid secretion in isolated human gastric glands. The present investigation aimed to further determine whether this action of NO was mediated by the activation of guanylyl cyclase (GC) and subsequent production of cGMP. Isolated gastric glands were obtained after enzymatic digestion of biopsies taken from the oxyntic mucosa of healthy volunteers. Acid secretion was assessed by measuring [14C]aminopyrine accumulation, and the concentration of cGMP was determined by radioimmunoassay. In addition, immunohistochemistry was used to examine the localization of cGMP in mucosal preparations after stimulation with the NO donor S-nitroso- N-acetylpenicillamine (SNAP). SNAP (0.1 mM) was shown to decrease acid secretion stimulated by histamine (50 μM); this effect was accompanied by an increase in cGMP production, which was histologically localized to parietal cells. The membrane-permeable cGMP analog dibuturyl-cGMP (db-cGMP; 0.1–1 mM) dose dependently inhibited acid secretion. Additionally, the effect of SNAP was prevented by preincubating the glands with the GC inhibitor 4 H-8-bromo-1,2,4-oxadiazolo[3,4-d]benz[b][1,4]oxazin-1-one (10 μM). We therefore suggest that NO in the human gastric mucosa is of physiological importance in regulating acid secretion. Furthermore, the results show that NO-induced inhibition of gastric acid secretion is a cGMP-dependent mechanism in the parietal cell involving the activation of GC.

Clinic of gastritis with preserved and increased secretory function of the stomach

1936 ◽  
Vol 32 (7) ◽  
pp. 808-817
Author(s):  
S. O. Badylkes ◽  
V. Z. Kudashevich ◽  
E. O. Eingorn
Keyword(s):  
Chronic Gastritis ◽  
Clinical Picture ◽  
Secretory Function ◽  
Plastic Characteristic ◽  
Long Time ◽  
Clinical Concept

The clinical concept "gastritis" has existed for a long time. Nevertheless, the need to create a clinical picture of chronic gastritis has matured, and this is recognized by many authors. For example, they say: There is no plastic characteristic clinical picture of gastritis.

Intracellular pH measurements in gastric mucosa.

1979 ◽  
Vol 237 (1) ◽  
pp. E82
Author(s):  
S J Hersey
Keyword(s):  
Gastric Mucosa ◽  
Acid Secretion ◽  
Intracellular Ph ◽  
Ph Indicator ◽  
Active Secretion ◽  
Ph Measurements ◽  
Tubular Cells ◽  
A Value ◽  
Indicator Dye ◽  
Secretion Rates

Intracellular pH was measured in bullfrog gastric mucosa using a pH-indicator dye, bromthymol blue (BTB), with a spectrophotometric technique. Studies showed that BTB is taken up by the gastric mucosa and bound to intracellular components. The binding of BTB was shown to cause a shift in the pKa of the dye from the solution value of 6.95 to a value of 8.0. During the nonsecreting state, intracellular pH was estimated to be 7.4 (metiamide inhibition) or 7.1 (SCN inhibition). During active secretion of acid, intracellular pH increased with increasing secretion rates, reaching values in excess of pH 8. Using preparations from which the surface epithelial cells had been removed, it was shown that at least a portion of the alkaline response to stimulation occurs in the oxyntic or tubular cells. The results are interpreted in view of existing models for the chemical reaction involved in gastric acid secretion.

scholarly journals Statistical analysis of the сhronic gastritis in students

2020 ◽  
Vol 73 (2) ◽  
pp. 360-364
Author(s):  
Aleksandr V. Kharchenko ◽  
Nataliya V. Kharchenko ◽  
Petro M. Makarenko ◽  
Lyudmyla M. Sakharova ◽  
Pavlo V. Khomenko ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Statistical Analysis ◽  
Gastric Mucosa ◽  
Atrophic Gastritis ◽  
Mucous Membrane ◽  
Chronic Gastritis ◽  
Bacterial Contamination ◽  
The Body ◽  
Leukocyte Infiltration ◽  
Lesser Curvature

The aim: The aim of the study is a statistical analysis of the mucosa of the stomach affected by Helicobacter pylori in young people studying at the university. Materials and methods: The work contains the results of the study of chronic gastritis of type B in university volunteer students. The study was attended by students of 1-4 courses, aged 17 to 25 years, a total of 50 people. Among them were 28 men and 22 women. Results: Various forms of chronic gastritis were found in the mucosa of the topographic-anatomical sections of the stomach, 90% of which were associated with Helicobacter pylori (HP). In all departments there is a different amount of common forms of chronic gastritis. In the pyloric section only atrophic gastritis was detected – 31.0 ± 8.5. Atrophic gastritis was also dominant on the lesser curvature – 32.3 ± 7.8, but its forms were significantly (p <0.5) less pronounced than in the pyloric section. In the area of the body, the above variants of chronic gastritis were found in 34.3 ± 8.7 cases, and the majority were flat erosive gastritis 51.0 ± 9.3. There is a tendency to reduce the degree of bacterial contamination of the gastric mucosa from its pyloric section and the lesser curvature to the walls of the body. With a decrease in the degree of bacterial contamination of the gastric mucosa, the degree of leukocyte infiltration also decreases. Between the degree of contamination of the mucous membrane of Helicobacter pylori and the degree of leukocyte infiltration of the mucous membrane, the Pearson correlation coefficient is rxy – 0,935, the correlation is very strong, the coefficient of determination is D=rxy^2 – 0,874, the statistically significant dependence on the probability is 0.99. Conclusions: Atrophic or hyperplastic gastritis associated with HP is found in the gastric mucosa, respectively, 90% of cases. The degree of bacterial contamination correlates with the degree of leukocyte infiltration of the gastric mucosa. Atrophic or hyperplastic gastritis Helicobacter pylori-associated is a common disease of people in young and working age.

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