The study on the ultrastructure of gastric mucosa and secretory function in chronic gastritis

The use of applications of dimethyl sulfoxide in patients with ulcerative disease and chronic gastritis leads to suppression of increased acid secretion, ambivalence with normal acid secretion and has no effect in patients with atrophy of the gastric mucosa. The normalizing effect of dimethyl sulfoxide (DMSO) applications in persons with acidic, decompensated ^ and subcompensated states of the stomach by stimulating the neutralizing function of the antral glands was established. The use of dimethyl sulfoxide as a transporter of various drugs in physiotherapy can be indicated in patients with HC1 hypersecretion in the interdigestive phase of ventricular secretion.

Download Full-text

Relationship between morphological change of the gastric mucosa and acid secretory function in chronic gastritis

Gastroenterologia Japonica ◽

10.1007/bf02779530 ◽

1973 ◽

Vol 8 (1) ◽

pp. 20-21

Author(s):

S. Fukuchi ◽

K. Mochizuki

Keyword(s):

Gastric Mucosa ◽

Morphological Change ◽

Chronic Gastritis ◽

Secretory Function

Download Full-text

ORAL INTAKE OF PURIFIED AQUEOUS SOLUTION OF OAT ?-GLUCANS HAS NO EFFECT ON GASTRIC MUCOSA HISTOLOGICAL CHANGES IN PATIENTS WITH CHRONIC GASTRITIS: A PILOT PHASE II CLINICAL TRIAL

10.26226/morressier.57c5383cd462b80296c9c8fb ◽

2016 ◽

Author(s):

Rafal Filip

Keyword(s):

Clinical Trial ◽

Aqueous Solution ◽

Gastric Mucosa ◽

Phase Ii ◽

Chronic Gastritis ◽

Oral Intake ◽

Phase Ii Clinical Trial ◽

Pilot Phase ◽

Histological Changes

Download Full-text

Relation of Helicobacter pylori to the human gastric mucosa in chronic gastritis of the antrum.

Gut ◽

10.1136/gut.31.11.1230 ◽

1990 ◽

Vol 31 (11) ◽

pp. 1230-1236 ◽

Cited By ~ 61

Author(s):

L L Thomsen ◽

J B Gavin ◽

C Tasman-Jones

Keyword(s):

Helicobacter Pylori ◽

Gastric Mucosa ◽

Chronic Gastritis ◽

Human Gastric Mucosa

Download Full-text

Clinic of gastritis with preserved and increased secretory function of the stomach

Kazan medical journal ◽

10.17816/kazmj49872 ◽

1936 ◽

Vol 32 (7) ◽

pp. 808-817

Author(s):

S. O. Badylkes ◽

V. Z. Kudashevich ◽

E. O. Eingorn

Keyword(s):

Chronic Gastritis ◽

Clinical Picture ◽

Secretory Function ◽

Plastic Characteristic ◽

Long Time ◽

Clinical Concept

The clinical concept "gastritis" has existed for a long time. Nevertheless, the need to create a clinical picture of chronic gastritis has matured, and this is recognized by many authors. For example, they say: There is no plastic characteristic clinical picture of gastritis.

Download Full-text

Statistical analysis of the сhronic gastritis in students

Wiadomości Lekarskie ◽

10.36740/wlek202002129 ◽

2020 ◽

Vol 73 (2) ◽

pp. 360-364

Author(s):

Aleksandr V. Kharchenko ◽

Nataliya V. Kharchenko ◽

Petro M. Makarenko ◽

Lyudmyla M. Sakharova ◽

Pavlo V. Khomenko ◽

...

Keyword(s):

Helicobacter Pylori ◽

Statistical Analysis ◽

Gastric Mucosa ◽

Atrophic Gastritis ◽

Mucous Membrane ◽

Chronic Gastritis ◽

Bacterial Contamination ◽

The Body ◽

Leukocyte Infiltration ◽

Lesser Curvature

The aim: The aim of the study is a statistical analysis of the mucosa of the stomach affected by Helicobacter pylori in young people studying at the university. Materials and methods: The work contains the results of the study of chronic gastritis of type B in university volunteer students. The study was attended by students of 1-4 courses, aged 17 to 25 years, a total of 50 people. Among them were 28 men and 22 women. Results: Various forms of chronic gastritis were found in the mucosa of the topographic-anatomical sections of the stomach, 90% of which were associated with Helicobacter pylori (HP). In all departments there is a different amount of common forms of chronic gastritis. In the pyloric section only atrophic gastritis was detected – 31.0 ± 8.5. Atrophic gastritis was also dominant on the lesser curvature – 32.3 ± 7.8, but its forms were significantly (p <0.5) less pronounced than in the pyloric section. In the area of the body, the above variants of chronic gastritis were found in 34.3 ± 8.7 cases, and the majority were flat erosive gastritis 51.0 ± 9.3. There is a tendency to reduce the degree of bacterial contamination of the gastric mucosa from its pyloric section and the lesser curvature to the walls of the body. With a decrease in the degree of bacterial contamination of the gastric mucosa, the degree of leukocyte infiltration also decreases. Between the degree of contamination of the mucous membrane of Helicobacter pylori and the degree of leukocyte infiltration of the mucous membrane, the Pearson correlation coefficient is rxy – 0,935, the correlation is very strong, the coefficient of determination is D=rxy^2 – 0,874, the statistically significant dependence on the probability is 0.99. Conclusions: Atrophic or hyperplastic gastritis associated with HP is found in the gastric mucosa, respectively, 90% of cases. The degree of bacterial contamination correlates with the degree of leukocyte infiltration of the gastric mucosa. Atrophic or hyperplastic gastritis Helicobacter pylori-associated is a common disease of people in young and working age.

Download Full-text

The Mechanisms of Sijunzi Decoction in the Treatment of Chronic Gastritis Revealed by Network Pharmacology

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/8850259 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Ting Wang ◽

Yuyin Feng ◽

Hesong Wang ◽

Guiyang Huo ◽

Yanan Cai ◽

...

Keyword(s):

Gastric Mucosa ◽

Inflammatory Response ◽

Chronic Gastritis ◽

Peripheral Blood ◽

Network Pharmacology ◽

Rna Seq ◽

Peripheral Blood Leukocytes ◽

Blood Leukocytes ◽

Superficial Gastritis ◽

Chronic Superficial Gastritis

Chronic gastritis is characterized by inflammation in the gastric mucosa with a vicious circle in inflammatory cells and inflammatory mediators. Stomach adenocarcinoma would occur in the metaplastic gastric mucosa of chronic gastritis. Sijunzi decoction is a famous classical formula for the treatment of chronic gastritis. Although previous studies revealed some functions of Sijunzi decoction in treating chronic gastritis, the underlying mechanisms have not been illustrated clearly. In this study, we used network pharmacology to investigate the mechanism of Sijunzi decoction in treating chronic gastritis. Firstly, online datasets TCMSP, SWISS, and DisGeNET were used to investigate the functional mechanism of Sijunzi decoction against chronic gastritis and 18 genes were identified as targets of Sijunzi decoction in chronic gastritis. These 18 genes can be categorized into immunologically related genes and cancer-related genes. GO analysis showed that the 18 target genes were mainly enriched in angiogenesis, nitric oxide biosynthetic process, ERK1 and ERK2 cascade, cellular response to drug, and MAPK cascade. So, Sijunzi decoction alleviated chronic gastritis by inhibiting the local inflammatory response. Furthermore, we also investigated the impact of Sijunzi decoction on the peripheral blood leukocytes with our own RNA sequencing (RNA-seq) data of 11 chronic superficial gastritis patients. 102 differentially expressed genes (DEGs) were identified by comparing RNA-seq data of chronic superficial gastritis patients with healthy control groups. After performing a functional analysis on 102 DEGs and Sijunzi decoction potential targets and taking the intersection of these pathways, we found that platelet activation, angiogenesis, and pathways in cancer were candidate target pathways regulated by Sijunzi decoction. Thus, Sijunzi decoction also alleviates chronic gastritis by suppressing inflammatory response of peripheral blood leukocytes. Our results showed that Sijunzi decoction can ameliorate the local gastric inflammation and inflammations in peripheral blood leukocytes and might also reduce the incidence of stomach cancer in chronic gastritis.

Download Full-text

Helicobacter pylori and Epstein–Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism

Journal of Oncology ◽

10.1155/2019/1785132 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Fasciana Teresa ◽

Nicola Serra ◽

Giuseppina Capra ◽

Chiara Mascarella ◽

Cesare Gagliardi ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Gastric Mucosa ◽

Chronic Gastritis ◽

Epstein Barr Virus ◽

Normal Gastric Mucosa ◽

Gastric Diseases ◽

Barr Virus ◽

Genes Encoding ◽

Epstein Barr

Introduction. Helicobacter pylori and Epstein–Barr virus (EBV) infection have recently been shown to be associated with gastric diseases. Polymorphisms in genes encoding cytokines such as interleukin 10 (IL-10) and interleukin 1 Receptor (IL-1RN) influence cytokine secretion levels and appear to contribute to the risk of developing gastroduodenal diseases. To our knowledge, this is the first preliminary study to address the association of coinfection with H. pylori and EBV and their correlation with genetic predisposition in the development of gastric diseases. Methods. Gastric biopsy samples of 96 patients with different gastric diseases were used. Results. Our results showed that the rate of coinfection was higher in patients with gastric cancer than in patients with normal gastric mucosa, active chronic gastritis, and MALT lymphoma. As regards the characterization of H. pilory strains, the polymorphism s1m1i1 of vacA gene was more frequent in patients with MALT Lymphoma in comparison to others, while the polymorphism s2m2i2 was most frequent in patients with normal gastric mucosa. In addition, patients who tested positive for the cagA gene were more frequently those affected with gastric cancer than those with inactive chronic gastritis. Similarly, the patients with oipA gene ON were more frequently those with gastric cancer than those with inactive chronic gastritis. Conclusion. According to our analysis, there was no correlation between coinfection and polymorphisms in genes encoding IL-10 and IL-1RN. We conclude that various factors can be involved in the development of gastric diseases.

Download Full-text