scholarly journals SAFETY OF NEW SUBSTANCES WITH PROTECTIVEACTIVITY IN ACUTE EXOGENOUS HYPOXIA

2012 ◽  
Vol 10 (4) ◽  
pp. 58-62
Author(s):  
Denis Vladimirovich Sosin ◽  
Andrey Viktorovich Yevseyev ◽  
Petr Dmitriyevich Shabanov
Keyword(s):  
Metal Complex ◽  
Toxic Chemical ◽  
Pharmacological Activities ◽  
Chemical Agents ◽  
Preclinical Investigation

In the article are represented results of both acute toxicities and safety determination of selenium-containing metal-complex substances πQ1983, πQ2170 that have high pharmacological activities in acute exogenous hypoxia after their introperitoneal or enteral introductions in mice. According with established parameters LD50 the couple of studied substances must be referred to the category of high toxic chemical agents. However, substance πQ1983 can be recommended for its preclinical investigation because it has enough permissible parameters of ED50 and therapeutic indexes.

scholarly journals Determination of Flavonoids Compounds of Three Species and Different Harvesting Periods in Crataegi folium Based on LC-MS/MS

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1602
Author(s):  
Ya-Ping Guo ◽  
Hong Yang ◽  
Ya-Li Wang ◽  
Xiao-Xiang Chen ◽  
Ke Zhang ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Quantitative Method ◽  
Total Content ◽  
Qualitative And Quantitative Analysis ◽  
Pharmacological Activities ◽  
Time Saving ◽  
Qualitative And Quantitative ◽  
First Time

Crataegi folium have been used as medicinal and food materials worldwide due to its pharmacological activities. Although the leaves of Crataegus songorica (CS), Crataegus altaica (CA) and Crataegus kansuensis (CK) have rich resources in Xinjiang, China, they can not provide insights into edible and medicinal aspects. Few reports are available on the qualitative and quantitative analysis of flavonoids compounds of their leaves. Therefore, it is necessary to develop efficient methods to determine qualitative and quantitative flavonoids compounds in leaves of CS, CA and CK. In the study, 28 unique compounds were identified in CS versus CK by qualitative analysis. The validated quantitative method was employed to determine the content of eight flavonoids of the leaves of CS, CA and CK within 6 min. The total content of eight flavonoids was 7.8–15.1 mg/g, 0.1–9.1 mg/g and 4.8–10.7 mg/g in the leaves of CS, CA and CK respectively. Besides, the best harvesting periods of the three species were from 17th to 26th September for CS, from 30th September to 15th October for CA and CK. The validated and time-saving method was successfully implemented for the analysis of the content of eight flavonoids compounds in CS, CA and CK for the first time.

Determination of the binding site size of hexaammineruthenium(iii) inside monolayers of DNA on gold

The Analyst ◽  
2021 ◽  
Author(s):  
Alireza Abi ◽  
Afsaneh Safavi
Keyword(s):  
Metal Complex ◽  
Binding Site ◽  
Dna Strands

Hexaammineruthenium(iii) metal complex can bind to surface-tethered DNA strands in excess of what is required for the compensation of the DNA charges.

scholarly journals Metallation of Isatin (2,3-Indolinedione). X-Ray Structure and Solution Behavior of Bis(Isatinato)Mercury(II)

1995 ◽  
Vol 2 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Angel Garcia-Raso ◽  
Juan J. Fiol ◽  
Elies Molins ◽  
Antonia M. Calafat ◽  
Patricia A. Marzilli ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Solid State ◽  
Metal Complex ◽  
Bond Length ◽  
Spectral Data ◽  
Structure Determination ◽  
Monoclinic System ◽  
Heterocyclic Nitrogen ◽  
X Ray

The first X-ray structure of an isatin (2,3-indolinedione, isaH) metal complex, bis(isatinato)memury(II) (C16H8N2O4Hg) (1), was determined. (1) was obtained from the reaction of isaH with mercury(II) acetate in methanol. Analogously, treatment of sodium saccharinate and mercury(II) acetate in methanol yielded Hg(saccharinato)2•0.5CH3OH (3). (1) crystallizes in the monoclinic system, space group P21/a with a = 7.299(1) Å, b = 8.192(1) Å, c = 11.601(1) Å , β = 105.82(1)°, V = 667.4 Å3, Z = 2, Dcalc = 2.452 g cm−3, MoKα radiation(λ = 0.71073 Å), μ = 115.5 cm-1, F(000) = 460, 21(1) °C. The structure was refined on the basis of 2023 observed reflections to R= 0.044. The two deprotonated, non coplanar isa ligands are trans to each other in a head to tail orientation and bound to the Hg through the nitrogen in a linear N-Hg-N arrangement. The Hg atom is at the center of symmetry of the complex and displaced by 0.62 Å from the two planes of the isa ligands (τ Hg-N1-C2-O2= -16°). The Hg-N bond length is 2.015 Å. Noπ-aryl-memury(ll)-π-aryl stacking interaction was observed either in the solid state or in the solution state. The IR, electronic, and H1 and C13NMR spectral data of (1) and (3) suggest binding of the memury to the heterocyclic nitrogen, in agreement with the crystal structure determination of (1).

scholarly journals Spectrophotometric Determination of Urinary Protein with o-Sulfophenylfluorone-Metal Complex

2005 ◽  
Vol 21 (10) ◽  
pp. 1237-1240 ◽  
Author(s):  
Takako YAMAGUCHI ◽  
Emi AMANO ◽  
Shinichiro KAMINO ◽  
Satoko UMEHARA ◽  
Chizuko YANAIHARA ◽  
...  
Keyword(s):  
Metal Complex ◽  
Spectrophotometric Determination ◽  
Urinary Protein

The Synthesis, Structure and Catalytic Properties of Some Aluminophosphate and Gallophosphate Materials Prepared Using Chiral Metal Complex Templates

1996 ◽  
Vol 431 ◽  
Author(s):  
A. P. Wilkinson ◽  
M. J. Gray ◽  
S. M. Stalder
Keyword(s):  
Crystal Structure ◽  
Metal Complex ◽  
Structure Determination ◽  
Catalytic Properties ◽  
Layered Material ◽  
Crystal Structure Determination ◽  
Synthesis And Crystal Structure

AbstractThe synthesis and crystal structure determination of d,l-Co(en)3.Ga3P4O16, xH2O (Pnna, a = 8.6502(9), b = 21.528(3), c = 13.717(2) Å) is described. This novel layered material contains Ga3P4O163- macroanions. The preparation and preliminary catalytic testing of a vanadium doped aluminophosphate that is isostructural with the gallophosphate is also discussed.

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