scholarly journals Cerebrovascular Lesions in Pick Complex Diseases – A Neuropathological Study with a 7.0-Tesla Magnetic Resonance Imaging Study

2017 ◽  
Vol 12 (02) ◽  
pp. 84 ◽  
Author(s):  
Jacques L De Reuck ◽  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cerebral Hemisphere ◽  
Imaging Study ◽  
Complex Diseases ◽  
Corticobasal Degeneration ◽  
Resonance Imaging ◽  
Cerebrovascular Lesions ◽  
Neurodegenerative Process ◽  
Low Incidence

Pick complex refers to a spectrum of diseases that include the presence of tau. The main neuropathological phenotypes comprise tau-frontotemporal lobar degeneration (tau-FTLD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). The present neuropathological study investigated the incidence of cerebrovascular lesions, including the small lesions detected microscopically on a large coronal section of a cerebral hemisphere at the level of the mammillary body. In addition the severity and distribution of white matter changes (WMCs), cortical microinfarcts (CoMIs) and cortical microbleeds (CoMBs) are examined with 7.0-tesla magnetic resonance imaging (MRI) on three coronal sections of a cerebral hemisphere. On neuropathological examination severe WMCs and more CoMBs are observed in tau-FTLD, while the latter are also more frequent in CBD. The MRI examination shows that severe WMCs are present in the frontal section of not only the tau-FTLD, but the PSP and CBD brains, albeit to a lesser degree. Severe WMCs and the increased number of CoMBs are related directly to the neurodegenerative process and do not represent additional cerebrovascular disease. The Pick complex diseases have a low incidence of real cerebrovascular lesions in common.

Post-mortem Magnetic Resonance Imaging as an Additional Tool of the Neuropathological Examination of Neurodegenerative and Cerebrovascular Diseases

2016 ◽  
Vol 11 (1) ◽  
pp. 22 ◽  
Author(s):  
Jacques L De Reuck ◽  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cerebral Hemisphere ◽  
Small Samples ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Cerebrovascular Lesions ◽  
Additional Tool ◽  
Neuropathological Examination

Neuropathological examination of post-mortem brains of patients with dementia due to neurodegenerative and cerebrovascular changes remains important, as the family wants to be sure about the clinical diagnosis and the risk of a hereditary disease. 7.0-tesla magnetic resonance imaging (MRI) can be applied as an additional tool to examine post-mortem brains of patients with neurodegenerative and cerebrovasular diseases. It allows examination of serial coronal sections of a cerebral hemisphere and horizontal sections of brainstem and cerebellum and comparison with the neuropathological lesions. Post-mortem MRI can show the degree and the distribution of the cerebral atrophy. Additional small cerebrovascular lesions can be quantified. The degree of iron load, not due to microbleeds, can be evaluated in different basal ganglia and brainstem structures. Three to six serial sections of a cerebral hemisphere and one section of brainstem and cerebellum allow the evaluation of the most important brain changes and to select the small samples to be used for histological diagnostic purposes. These correlation studies are extremely important for the future, when more 7.0-tesla MRI machines will be available forin vivoclinical-radiological diagnosis. This article is a review of post-mortem MRI data in the brains of patients with neurodegenerative and vascular dementias.

Dependence of Blood Clot Lysis on the Mode of Transport of Urokinase into the Clot - A Magnetic Resonance Imaging Study in Vitro

1991 ◽  
Vol 65 (05) ◽  
pp. 549-552 ◽  
Author(s):  
A Blinc ◽  
G Planinšič ◽  
D Keber ◽  
O Jarh ◽  
G Lahajnar ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Pressure Difference ◽  
Volume Flow Rate ◽  
Blood Clot ◽  
Linear Regression Analysis ◽  
Imaging Study ◽  
Clot Lysis ◽  
Resonance Imaging

SummaryMagnetic resonance imaging was employed to study the dependence of clot lysing patterns on two different modes of transport of urokinase into whole blood clots. In one group of clots (nonperfused clots, n1 = 10), access of urokinase to the fibrin network was possible by diffusion only, whereas in the other group (perfused clots, n2 = 10) bulk flow of plasma containing urokinase was instituted through occlusive clots by a pressure difference of 3 .7 kPa (37 cm H2O) across 3 cm long clots with a diameter of 4 mm. It was determined separately that this pressure difference resulted in a volume flow rate of 5.05 ± 2.4 × 10−2 ml/min through occlusive clots. Perfused clots diminished in size significantly in comparison to nonperfused ones already after 20 min (p <0.005). Linear regression analysis of two-dimensional clot sizes measured by MRI showed that the rate of lysis was more than 50-times faster in the perfused group in comparison to the nonperfused group. It was concluded that penetration of the thrombolytic agent into clots by perfusion is much more effective than by diffusion. Our results might have some implications for understanding the differences in lysis of arterial and venous thrombi.

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