scholarly journals MANNOSE BINDING LECTIN (MBL) GENE POLYMORPHISMS AND THEIR RELATIONS WITH CLINICAL FEATURES IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER (FMF)

2017 ◽  
pp. 125-130
Author(s):  
Ertugrul Erken ◽  
Ozlem Kudas ◽  
Suzan Dinkci ◽  
Yunus Kuyucu ◽  
Turker Tasliyurt ◽  
...  
Meta Gene ◽  
2020 ◽  
Vol 26 ◽  
pp. 100757
Author(s):  
Felipe Rodolfo Pereira da Silva ◽  
Alessandro Luiz Araújo Bentes Leal ◽  
Luigi Nibali ◽  
Jae Il Shin ◽  
Marcelo Diniz Carvalho ◽  
...  

2008 ◽  
Vol 28 (5) ◽  
pp. 495-500 ◽  
Author(s):  
Eirini Koutsounaki ◽  
George N. Goulielmos ◽  
Mary Koulentaki ◽  
Christianna Choulaki ◽  
Elias Kouroumalis ◽  
...  

2019 ◽  
Vol 54 ◽  
pp. 29-37 ◽  
Author(s):  
Michał Czerewaty ◽  
Maciej Tarnowski ◽  
Krzysztof Safranow ◽  
Leszek Domanski ◽  
Andrzej Pawlik

2005 ◽  
Vol 192 (8) ◽  
pp. 1355-1361 ◽  
Author(s):  
Hongxing Zhang ◽  
Gangqiao Zhou ◽  
Lianteng Zhi ◽  
Hao Yang ◽  
Yun Zhai ◽  
...  

Abstract BackgroundGenetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China MethodsThe frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt −550, −221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing ResultsOf 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25–2.39]; P=.00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21–2.29]; P=.00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%–32.3%) Conclusions MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant


2008 ◽  
Vol 51 (7) ◽  
pp. 548-553 ◽  
Author(s):  
Xintao Wang ◽  
Yoshinori Ohtsuka ◽  
Kiyonobu Kimura ◽  
Hiroshi Kaji ◽  
Junpei Saito ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document