scholarly journals Conformational Analysis, Substituent Effect and Structure Activity Relationships of 16-Membered Macrodiolides

2014 ◽  
Vol 33 ◽  
pp. 146-167 ◽  
Author(s):  
Radhia Mazri ◽  
Salah Belaidi ◽  
Aicha Kerassa ◽  
Touhami Lanez
Keyword(s):  
Biological Activity ◽  
Conformational Analysis ◽  
Electronic Structures ◽  
Substituent Effect ◽  
Dipole Moments ◽  
Ab Initio Methods ◽  
Electron Affinities ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Net Charges

Electronic structures, Conformational Analysis, effect of the substitution and structure activity Relationships for macrodiolides, have been studied by PM3 and ab initio methods. In the present work, the calculated values, namely net charges, bond lengths, MESP, dipole moments, electron-affinities, heats of formation, drug-likeness and QSAR properties, are reported and discussed in terms of the biological activity of macrodiolides.

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

scholarly journals Brassinosteroid phytohormones: structure, bioactivity and applications

2002 ◽  
Vol 14 (3) ◽  
pp. 143-181 ◽  
Author(s):  
Marco António Teixeira Zullo ◽  
Günter Adam
Keyword(s):  
Biological Activity ◽  
Plant Growth ◽  
Plant Hormones ◽  
Natural Occurrence ◽  
Regulatory Activity ◽  
Structure Activity Relationships ◽  
New Class ◽  
Structure Activity ◽  
Activity Structure ◽  
Steroid Structure

Brassinosteroids are a new class of plant hormones with a polyoxygenated steroid structure showing pronounced plant growth regulatory activity. This review covers their natural occurrence, biological and chromatographic methods for their detection, biosynthesis and metabolism, biological activity, structure-activity relationships and prospective agricultural uses.

Adenosine receptors: synthesis, structure-activity relationships and biological activity of new 6-amino purine derivatives

1998 ◽  
Vol 33 (6) ◽  
pp. 501-508 ◽  
Author(s):  
Giovannella Strappaghetti ◽  
Stefano Corsano ◽  
Roberta Barbaro ◽  
Antonio Lucacchini ◽  
Gino Giannaccini ◽  
...  
Keyword(s):  
Biological Activity ◽  
Adenosine Receptors ◽  
Purine Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity

ChemInform Abstract: Adenosine Receptors: Synthesis, Structure-Activity Relationships and Biological Activity of New 6-Amino Purine Derivatives.

ChemInform ◽  
2010 ◽  
Vol 30 (3) ◽  
pp. no-no
Author(s):  
G. STRAPPAGHETTI ◽  
S. CORSANO ◽  
R. BARBARO ◽  
A. LUCACCHINI ◽  
G. GIANNACCINI ◽  
...  
Keyword(s):  
Biological Activity ◽  
Adenosine Receptors ◽  
Purine Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity
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