scholarly journals Onset of nut allergy in a pediatric cohort: clinical and molecular patterns. AFRUSEN study

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
MD Ibáñez-Sandin ◽  
◽  
P Rodríguez del Río ◽  
MI Alvarado ◽  
BE García ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Peanut Allergy ◽  
Storage Proteins ◽  
Food Challenge ◽  
Clinical History ◽  
Preventive Strategies ◽  
Anglo Saxon ◽  
2S Albumins ◽  
Molecular Patterns ◽  
First Time

Background: Nut allergy is a growing problem, but little is known about its onset in children. Objective: Characterize the onset of nut allergy in Southern European children. Methods: Consecutive patients up to 14years of age who presented to allergy departments with an initial allergic reaction to peanut, tree nut, or seed were included. An allergy workup including clinical history, food challenge, SPT, and whole-extract sIgE and ImmunoCAP 112-ISAC assay were performed. Results: Of the 271 children included, 260 were first diagnosed with nut allergy at age 6.5years, 11.8(±21.2SD) months after the index reaction. The most common culprit nuts at onset were walnut (36.5%), peanut (28.5%), cashew(10.4%), hazelnut (8.5%), pistachio (5.4%), and almond (5%). Peanut-allergy onset was more frequent in children ≤6y.o. and walnut in those >6y.o. (p=0.032). In 65% of cases, the allergic reaction occurred the first time the patient consumed the nut, and 35% of reactions were anaphylactic. Overall, nut polysensitization was detected by SPT in 64.9% of patients, though this rate was lower among walnut- (54.7%) and peanut (54.1%)-allergic children (p<0.0001). Sensitization to 2S albumins was predominant (75%), specially Jug r1 (52.8%), whereas LTPs was less relevant (37%). Conclusion: In our population, the onset of nut allergy occured around 6years of age, slightly later than that reported in Anglo-Saxon countries. Walnut was the main trigger, followed by peanut and 2S albumins storage proteins, especially Jug r1, are the most relevant allergens. This study will help guide management and may contribute to preventive strategies in pediatric nut allergy.

scholarly journals White paper peanut allergy—part 2: Diagnosis of peanut allergy with special emphasis on molecular component diagnostics

2021 ◽  
Author(s):  
Lea Alexandra Blum ◽  
Birgit Ahrens ◽  
Ludger Klimek ◽  
Kirsten Beyer ◽  
Michael Gerstlauer ◽  
...  
Keyword(s):  
Gold Standard ◽  
Peanut Allergy ◽  
Immunoglobulin E ◽  
Skin Prick Testing ◽  
Systemic Reaction ◽  
Food Challenge ◽  
Clinical History ◽  
Double Blind ◽  
Skin Reactions ◽  
Diagnostic Algorithms

Summary Background Peanut allergy is an immunoglobulin E (IgE)-mediated immune response that usually manifests in childhood and can range from mild skin reactions to anaphylaxis. Since quality of life maybe greatly reduced by the diagnosis of peanut allergy, an accurate diagnosis should always be made. Methods A selective literature search was performed in PubMed and consensus diagnostic algorithms are presented. Results Important diagnostic elements include a detailed clinical history, detection of peanut-specific sensitization by skin prick testing and/or in vitro measurement of peanut (extract)-specific IgE and/or molecular components, and double-blind, placebo-controlled food challenge as the gold standard. Using these tools, including published cut-off values, diagnostic algorithms were established for the following constellations: 1) Suspicion of primary peanut allergy with a history of immediate systemic reaction, 2) Suspicion of primary peanut allergy with questionable symptoms, 3) Incidental findings on sensitization testing and peanut ingestion so far or 4) Suspicion of pollen-associated peanut allergy with solely oropharyngeal symptoms. Conclusion The most important diagnostic measures in determining the diagnosis of peanut allergy are clinical history and detection of sensitizations, also via component-based diagnostics. However, in case of unclear results, the gold standard—an oral food challenge—should always be used.

Omalizumab In Peanut Allergy: Effects On The Basophil, Mast Cell, And Food Challenge Response

2011 ◽  
Vol 127 (2) ◽  
pp. AB28-AB28
Author(s):  
J.H. Savage ◽  
D. MacGlashan ◽  
S.S. Saini ◽  
R.A. Wood
Keyword(s):  
Mast Cell ◽  
Peanut Allergy ◽  
Food Challenge

THE ANGLO-NORMAN ABBEY CHURCH OF ST ALBANS AND THE AISLELESS NAVE OF ITS CRUCIFORM PREDECESSOR: THE MATERIAL EVIDENCE

2020 ◽  
pp. 1-15
Author(s):  
Jill A Franklin
Keyword(s):  
Conclusive Evidence ◽  
Diagnostic Feature ◽  
Anglo Saxon ◽  
Existing Building ◽  
Cruciform Structure ◽  
Anglo Norman ◽  
First Time ◽  
New Evidence ◽  
Material Evidence ◽  
Solid Walls

Within the Romanesque abbey church at St Albans (Hertfordshire), the vestiges of an earlier structure have been identified for the first time. A hitherto unrecorded feature in the transept, noted by the author in 2017, indicates that, at some stage, the nave lacked its existing arcade piers and instead had solid walls. The implications of this are considerable, calling for a thorough reassessment of the building’s history. For now, it is important to record the primary evidence, so as to make it available for further research. This article aims to provide a concise account of the evidence and a summary of what it might mean. According to the thirteenth-century chronicler, Matthew Paris, the existing church was begun in 1077 and completed in 1088. New evidence indicates, however, that the Romanesque building, with its aisled nave and presbytery, was preceded by a cruciform structure without aisles. The inference is that the existing building contains the fabric of this unaisled predecessor. The obvious conclusion – that it therefore represents the lost Anglo-Saxon abbey church – does not follow without question; as yet, excavation has yielded no conclusive evidence of an earlier church on the site. The critical diagnostic feature presented here for the first time adds substance to the view that the remodelling of unaisled buildings was not uncommon in the post-Conquest period, including large as well as minor churches, as identified long ago at York Minster and, more recently, at Worksop Priory.

scholarly journals Oral immunotherapy for treatment of peanut allergy

2020 ◽  
Vol 68 (6) ◽  
pp. 1152-1155
Author(s):  
Joan H Dunlop
Keyword(s):  
Food Allergy ◽  
Peanut Allergy ◽  
Food Challenge ◽  
Oral Immunotherapy ◽  
Peanut Protein ◽  
Subcutaneous Immunotherapy ◽  
Double Blind ◽  
The Us ◽  
Allergy Prevalence

The US Food and Drug Administration’s approval of a peanut oral immunotherapy product in January 2020 is a landmark development in the field of food allergy therapy. While food allergy prevalence has been increasing, this product is the first approved therapy for food allergy. Oral immunotherapy has many similarities to subcutaneous immunotherapy and drug desensitization protocols, but does not lead to sustained unresponsiveness. The studies leading to approval of the Palforzia product demonstrated increase in the amount of peanut protein able to be consumed, with 67% of subjects randomized to the treatment arm able to consume 600 mg of peanut protein in double-blind placebo-controlled food challenge at study exit. However, side effects are an important consideration, and dropout rates in studies of Palforzia ranged from 11% to 21%. Postmarketing surveillance of this product will be critical in assessing its long-term risks and benefits.

The Vikings in England: a review

1975 ◽  
Vol 4 ◽  
pp. 181-206 ◽  
Author(s):  
Gillian Fellows Jensen
Keyword(s):  
Twelfth Century ◽  
Life Time ◽  
Present Review ◽  
Place Names ◽  
Anglo Saxon ◽  
Domesday Book ◽  
First Time

In the preface to F. M. Stenton's collected papers Lady Stenton notes that the publication ofAnglo-Saxon Englandin 1943 marked the culmination of a life-time spent largely preparing for and writing a book in which ‘place-names, coins and charters, wills and pleas, archaeology and the laws of the Anglo-Saxons were all for the first time adequately used to produce a balanced narrative, supported by Domesday Book and the twelfth-century charters which made it easier to understand the earlier material’. Indeed, with the exception of archaeology, Sir Frank had been actively engaged in all these fields of research, as is revealed by the list of his published works, and it seemed unlikely at the time that it would ever be necessary to make major adjustments to the view of the Scandinavian settlements that he presented. Only twelve years had passed, however, when voices of dissent began to arise and the first of three papers that were to herald two decades of controversy about the Vikings in England was published. The present review examines the most significant contributions to the ensuing debate and considers whether it has, in fact, been necessary to depart substantially from the views held by Stenton.

scholarly journals Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Montserrat Guadalupe Garza-Reyes ◽  
Mónica Daniela Mora-Ruíz ◽  
Luis Chávez-Sánchez ◽  
Alejandra Madrid-Miller ◽  
Alberto Jose Cabrera-Quintero ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Inflammatory Diseases ◽  
Interleukin 17 ◽  
Monocyte Subsets ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Molecular Patterns ◽  
First Time ◽  
Circulating Levels

Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion.

A Newly Identified Figure of the Virgin from a Late Anglo-Saxon Rood at Great Hale, Lincolnshire

2000 ◽  
Vol 80 (1) ◽  
pp. 285-294 ◽  
Author(s):  
Paul Everson ◽  
David Stocker
Keyword(s):  
Distribution Patterns ◽  
Anglo Saxon ◽  
Funerary Monuments ◽  
East Midlands ◽  
Politics And Religion ◽  
Stone Sculpture ◽  
First Time

During survey and recording work undertaken by the authors for the Corpus of Anglo-Saxon Stone Sculpture project in Lincolnshire between 1984 and 1991, over 375 stones were analysed and some hundred or so new discoveries are reported in the final publication. The most important conclusions drawn by the volume relate to the identification, for the first time, of groups of Anglo-Scandinavian funerary monuments and to conclusions regarding political and ecclesiastical affiliations which can be drawn from their distribution patterns. This note seeks to bring to wider attention, however, a single find of greater importance to art-historical studies of the late Anglo-Saxon period, and one which stands to one side of our more general conclusions regarding Anglo-Scandinavian politics and religion in the East Midlands.

scholarly journals The Homiliary of Angers in tenth-century England

2010 ◽  
Vol 39 ◽  
pp. 163-192 ◽  
Author(s):  
Winfried Rudolf
Keyword(s):  
Old English ◽  
Tenth Century ◽  
British Library ◽  
Anglo Saxon ◽  
First Time ◽  
Made In

AbstractLatin manuscripts used for preaching the Anglo-Saxon laity in the tenth century survive in relatively rare numbers. This paper contributes a new text to the known preaching resources from that century in identifying the Homiliary of Angers as the text preserved on the flyleaves of London, British Library, MS Sloane 280. While these fragments, made in Kent and edited here for the first time, cast new light on the importance of this plain and unadorned Latin collection for the composition of Old English temporale homilies before Ælfric, they also represent the oldest surviving manuscript evidence of the text.

DISTRIBUTION OF VEGETATIVE STORAGE PROTEINS IN ROSACEAE

IAWA Journal ◽  
2003 ◽  
Vol 24 (4) ◽  
pp. 421-428
Author(s):  
Wei-Min Tian ◽  
Zheng-Hai Hu
Keyword(s):  
Seasonal Changes ◽  
Storage Proteins ◽  
Protein Body ◽  
Diagnostic Feature ◽  
Secondary Phloem ◽  
Apple Trees ◽  
Phloem Parenchyma ◽  
Vegetative Storage Proteins ◽  
Parenchyma Cells ◽  
First Time

The distribution pattern of vegetative storage proteins is reported for the first time for 18 species and 2 varieties of twelve genera of Rosaceae. Vegetative storage proteins were present in all the species studied of Prunoideae and absent in Maloideae. Their occurrence in a genus seemed to be either universal or entirely absent. Rosaceae trees were poor in vegetative storage proteins and the form of vegetative storage proteins was not protein body-like. Granular and floccular forms of vegetative storage proteins could be distinguished exclusively in the secondary phloem parenchyma cells and their distribution was cell-specific. Our results suggest that the distribution of vegetative storage proteins in Rosaceae can be considered as a taxonomically diagnostic feature. The nature of the bark proteins with seasonal changes in apple trees is discussed.

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