Carbamazepine-induced Stevens Johnson syndrome: a case series of three case reports

Stevens-Johnson syndrome (SJS) is a very rare, potentially fatal skin reaction that is typically the result of reaction to the drug. In particular, SJS is characterized by extensive skin and mucous membrane lesions (i.e. mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95 % of case reports, drugs were found to be an important cause for the development of SJS. This story is a case of A 42 year old male hospitalized with rashes all over the body and fever, after oral consumption of Amoxicillin drug for sore throat. This case study discusses the possibility that serious hypersensitivity reactions with Amoxicillin can rarely occur and can be extremely harmful and life-threatening Menacing. Keywords: Toxic Epidermal Necrolysis, Stevens Johnson Syndrome, Adverse drug reaction, Nikolsky’s sign

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Lamotrigine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Singapore: A case series

Annals of the Academy of Medicine, Singapore ◽

10.47102/annals-acadmedsg.2021326 ◽

2021 ◽

Vol 50 (12) ◽

pp. 915-918

Author(s):

Laura LY Hui ◽

Celine Loke ◽

Derrick CW Aw ◽

Liesbet Tan ◽

Lie Michael George Limenta ◽

...

Keyword(s):

Toxic Epidermal Necrolysis ◽

Case Series ◽

Stevens Johnson Syndrome ◽

Johnson Syndrome

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Bilateral Microbial Keratitis in Highly Active Antiretroviral Therapy-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Case Series

Ocular Immunology and Inflammation ◽

10.3109/09273948.2011.601389 ◽

2011 ◽

Vol 19 (5) ◽

pp. 343-345 ◽

Cited By ~ 6

Author(s):

Ritika Sachdev ◽

Shubha Bansal ◽

Rajesh Sinha ◽

Namrata Sharma ◽

Jeewan S. Titiyal

Keyword(s):

Antiretroviral Therapy ◽

Toxic Epidermal Necrolysis ◽

Highly Active Antiretroviral Therapy ◽

Case Series ◽

Stevens Johnson Syndrome ◽

Microbial Keratitis ◽

Highly Active ◽

Johnson Syndrome

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Suspected Lamotrigine-Induced Toxic Epidermal Necrolysis

Annals of Pharmacotherapy ◽

10.1177/106002809703100609 ◽

1997 ◽

Vol 31 (6) ◽

pp. 720-723 ◽

Cited By ~ 23

Author(s):

Julie J Chaffin ◽

Steven M Davis

Keyword(s):

Valproic Acid ◽

Toxic Epidermal Necrolysis ◽

Case Reports ◽

Stevens Johnson Syndrome ◽

Complex Partial Seizures ◽

Skin Reactions ◽

Johnson Syndrome ◽

Patient Reported ◽

History Of ◽

Relationship Of

OBJECTIVE: To describe a patient who developed toxic epidermal necrolysis (TEN) possibly secondary to lamotrigine use. CASE SUMMARY: A 74-year-old white man with a history of probable complex partial seizures was admitted to the neurology service for a prolonged postictal state. His antiepileptic regimen was changed while he was in the hospital to include lamotrigine. After 19 days of hospitalization and 14 days of lamotrigine therapy, the patient became febrile. The next day he developed a rash which progressed within 4 days to TEN, diagnosed by skin biopsy. All suspected drugs were discontinued, including lamotrigine. The patient was treated with hydrotherapy in the burn unit. His symptoms improved and he was discharged from the hospital 26 days after the rash developed. DISCUSSION: During lamotrigine's premarketing clinical trials, the manufacturer reported several cases of Stevens-Johnson syndrome and TEN. There are several published case reports of lamotrigine-induced severe skin reactions. All of these reports included patients being treated with both valproic acid and lamotrigine. Our patient was exposed to phenytoin, carbamazepine, clindamycin, and lamotrigine, but not valproic acid. The patient reported prior use of phenytoin with no skin rash. Carbamazepine was the antiepileptic drug the patient was maintained on prior to his hospital admission, and the symptoms of TEN resolved while he was still receiving carbamazepine. The patient received only two doses of clindamycin, which makes this agent an unlikely cause of TEN. CONCLUSIONS: Because of the temporal relationship of the onset of the patient's rash and several drugs that are known to cause severe rashes, it is not certain which drug was the definite culprit. However, based on the evidence from the literature, lamotrigine appears to be the causative agent.

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Docetaxel-Induced Stevens-Johnson Syndrome in a Patient with Metastatic Prostate Adenocarcinoma

Case Reports in Oncological Medicine ◽

10.1155/2019/7928752 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Osama Diab ◽

Dan Mcentire ◽

Thamer Kassim ◽

Ali Nayfeh ◽

Abdel Rahman Dajani ◽

...

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Metastatic Prostate Cancer ◽

Single Phase ◽

Chemotherapeutic Agent ◽

Case Reports ◽

Prostate Adenocarcinoma ◽

Stevens Johnson Syndrome ◽

Treatment Regimens ◽

Johnson Syndrome

Docetaxel is a commonly used chemotherapeutic agent in a variety of cancer treatment regimens. We present a case of apparent docetaxel-induced Stevens-Johnson syndrome (SJS) in a patient recently treated for metastatic prostate cancer. This medication is not classically associated with the development of SJS but in our case, along with a number of other case reports, and a single phase II clinical trial, an association was recognized. We encourage clinicians who employ the use of this medication to be aware of this relationship.

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