Exposure Level of Trichloroethylene in Stevens-Johnson Syndrome Due to Occupational Exposure: 3 Case Reports and a Review of Other Cases

Stevens-Johnson syndrome (SJS) is a very rare, potentially fatal skin reaction that is typically the result of reaction to the drug. In particular, SJS is characterized by extensive skin and mucous membrane lesions (i.e. mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95 % of case reports, drugs were found to be an important cause for the development of SJS. This story is a case of A 42 year old male hospitalized with rashes all over the body and fever, after oral consumption of Amoxicillin drug for sore throat. This case study discusses the possibility that serious hypersensitivity reactions with Amoxicillin can rarely occur and can be extremely harmful and life-threatening Menacing. Keywords: Toxic Epidermal Necrolysis, Stevens Johnson Syndrome, Adverse drug reaction, Nikolsky’s sign

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Carbamazepine-induced Stevens Johnson syndrome: a case series of three case reports

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20150394 ◽

2015 ◽

pp. 797-801 ◽

Cited By ~ 1

Author(s):

Arvind Kumar ◽

Dinesh Kansal ◽

Usha Chaudhary ◽

Ajay Sharma ◽

Reena Sharma

Keyword(s):

Case Reports ◽

Case Series ◽

Stevens Johnson Syndrome ◽

Johnson Syndrome

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Suspected Lamotrigine-Induced Toxic Epidermal Necrolysis

Annals of Pharmacotherapy ◽

10.1177/106002809703100609 ◽

1997 ◽

Vol 31 (6) ◽

pp. 720-723 ◽

Cited By ~ 23

Author(s):

Julie J Chaffin ◽

Steven M Davis

Keyword(s):

Valproic Acid ◽

Toxic Epidermal Necrolysis ◽

Case Reports ◽

Stevens Johnson Syndrome ◽

Complex Partial Seizures ◽

Skin Reactions ◽

Johnson Syndrome ◽

Patient Reported ◽

History Of ◽

Relationship Of

OBJECTIVE: To describe a patient who developed toxic epidermal necrolysis (TEN) possibly secondary to lamotrigine use. CASE SUMMARY: A 74-year-old white man with a history of probable complex partial seizures was admitted to the neurology service for a prolonged postictal state. His antiepileptic regimen was changed while he was in the hospital to include lamotrigine. After 19 days of hospitalization and 14 days of lamotrigine therapy, the patient became febrile. The next day he developed a rash which progressed within 4 days to TEN, diagnosed by skin biopsy. All suspected drugs were discontinued, including lamotrigine. The patient was treated with hydrotherapy in the burn unit. His symptoms improved and he was discharged from the hospital 26 days after the rash developed. DISCUSSION: During lamotrigine's premarketing clinical trials, the manufacturer reported several cases of Stevens-Johnson syndrome and TEN. There are several published case reports of lamotrigine-induced severe skin reactions. All of these reports included patients being treated with both valproic acid and lamotrigine. Our patient was exposed to phenytoin, carbamazepine, clindamycin, and lamotrigine, but not valproic acid. The patient reported prior use of phenytoin with no skin rash. Carbamazepine was the antiepileptic drug the patient was maintained on prior to his hospital admission, and the symptoms of TEN resolved while he was still receiving carbamazepine. The patient received only two doses of clindamycin, which makes this agent an unlikely cause of TEN. CONCLUSIONS: Because of the temporal relationship of the onset of the patient's rash and several drugs that are known to cause severe rashes, it is not certain which drug was the definite culprit. However, based on the evidence from the literature, lamotrigine appears to be the causative agent.

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Docetaxel-Induced Stevens-Johnson Syndrome in a Patient with Metastatic Prostate Adenocarcinoma

Case Reports in Oncological Medicine ◽

10.1155/2019/7928752 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Osama Diab ◽

Dan Mcentire ◽

Thamer Kassim ◽

Ali Nayfeh ◽

Abdel Rahman Dajani ◽

...

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Metastatic Prostate Cancer ◽

Single Phase ◽

Chemotherapeutic Agent ◽

Case Reports ◽

Prostate Adenocarcinoma ◽

Stevens Johnson Syndrome ◽

Treatment Regimens ◽

Johnson Syndrome

Docetaxel is a commonly used chemotherapeutic agent in a variety of cancer treatment regimens. We present a case of apparent docetaxel-induced Stevens-Johnson syndrome (SJS) in a patient recently treated for metastatic prostate cancer. This medication is not classically associated with the development of SJS but in our case, along with a number of other case reports, and a single phase II clinical trial, an association was recognized. We encourage clinicians who employ the use of this medication to be aware of this relationship.

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Levofloxacin induced Stevens-Johnson syndrome/ toxic epidermal necrolysis overlap syndrome: case reports

Clinical and Translational Allergy ◽

10.1186/2045-7022-4-s3-p91 ◽

2014 ◽

Vol 4 (S3) ◽

Cited By ~ 3

Author(s):

Maria Gloria Aversano ◽

Jan Schroeder ◽

Antonella Citterio ◽

Joseph Scibilia ◽

Chiara Gamba ◽

...

Keyword(s):

Toxic Epidermal Necrolysis ◽

Case Reports ◽

Overlap Syndrome ◽

Stevens Johnson Syndrome ◽

Johnson Syndrome

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ACECLOFENAC-INDUCED STEVENS-JOHNSON SYNDROME AFTER ONE SINGLE DOSE: A MAIDEN CASE REPORT

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i9.24067 ◽

2018 ◽

Vol 11 (9) ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Saurabh Agarwal ◽

Balaji O ◽

Navin Patil

Keyword(s):

Case Reports ◽

Tertiary Care ◽

Stevens Johnson Syndrome ◽

Care Hospital ◽

Skin Reactions ◽

Johnson Syndrome ◽

Organ Systems ◽

Major Organ ◽

Threatening Condition ◽

Life Threatening

Drugs are known to cause various adverse drug reactions involving major organ systems. Skin-related adverse reactions are very common and range from a simple rash to life-threatening condition like Stevens-Johnson syndrome. Various drugs are known to cause skin reactions which include antiepileptics, analgesics, antibiotics, and proton-pump inhibitors. Nonsteroidal anti-inflammatory drugs causing life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis are very rare and only few case reports are published. Hence, we report a case of Aceclofenac-induced Stevens-Johnson syndrome after single time administration in a tertiary care hospital in India.

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Stevens-Johnson syndrome associated with occupational exposure to trichloroethylene

Contact Dermatitis ◽

10.1111/j.1600-0536.1984.tb00145.x ◽

1984 ◽

Vol 10 (5) ◽

pp. 270-276 ◽

Cited By ~ 88

Author(s):

W. H. Phoon ◽

Magdalene O. Y. Chan ◽

V. S. Rajan ◽

K. J. Tan ◽

T. Thirumoorty ◽

...

Keyword(s):

Occupational Exposure ◽

Stevens Johnson Syndrome ◽

Johnson Syndrome

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The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China

Journal of Immunology Research ◽

10.1155/2018/4320195 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Shang-Chen Yang ◽

Sindy Hu ◽

Sheng-Zheng Zhang ◽

Jin-wen Huang ◽

Jing Zhang ◽

...

Keyword(s):

Toxic Epidermal Necrolysis ◽

Case Reports ◽

Statistical Significance ◽

Epidemiologic Studies ◽

Stevens Johnson Syndrome ◽

Systemic Steroid ◽

China National Knowledge Infrastructure ◽

Johnson Syndrome ◽

Life Threatening ◽

Medical University

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI) and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. There were 166 patients enrolled, including 70 SJS, 2 SJS/TEN overlap, and 94 TEN. The most common offending drugs were antibiotics (29.5%) and anticonvulsants (24.1%). Carbamazepine, allopurinol, and penicillins were the most common single offending drugs (17.5%, 9.6%, and 7.2%). Chinese patent medicines accounted for 5.4%. There were 76 (45.8%) patients receiving systemic steroid and intravenous immunoglobulin (IVIG) in combination therapy, especially for TEN (80.3%), and others were treated with systemic steroids alone. Mortality rate of combination treatment comparing with steroid alone in TEN patients had no statistical significance. In conclusion, carbamazepine and allopurinol were the leading causative drugs for SJS/TEN in China. Combination of IVIG and steroids is a common treatment for TEN, but its efficacy in improving mortality needs further investigation.

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