Fetomaternal outcome in women with hemolysis, elevated liver enzymes and low platelet count syndrome: a retrospective study

Background: HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome which is a variant form of severe preeclampsia is an important cause of maternal and fetal mortality and morbidity. The importance lies in the early diagnosis and timely intervention for better fetal and maternal outcome. The objective of this study was to assess the maternal and fetal outcome in pregnancies complicated with HELLP syndrome.Methods: This is a retrospective study analyzing fetomaternal outcome in 63 women diagnosed with HELLP syndrome in the department of obstetrics and gynecology, Government Medical College, Thrissur from 1st January 2014 to 31st December 2016. Details were collected from data records library.Results: Among 7,566 deliveries, 63 women (0.83%) had HELLP syndrome. Mean age was 29.5 years. 47.6% (n=30) women developed HELLP syndrome at gestational age less than 34 weeks. Maternal complications were abruption (27.78%), acute kidney injury (16.67%), DIC (16.67%), sepsis (11.11%) and postpartum hemorrhage (11.11%). In this study, HELLP syndrome lead to one maternal death (1.58%). The perinatal mortality was 25.75%.Conclusions: HELLP syndrome is an alarming complication, which brings high maternal and perinatal morbidity and mortality.

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The Impact Of Corticosteroid Administration On The Rate Of Regional Anesthesia In Patients With Hemolysis, Elevated Liver Enzymes And Low Platelet Count (HELLP Syndrome).

Anesthesiology ◽

10.1097/00000542-200004001-00101 ◽

2000 ◽

Vol 2000 (4) ◽

pp. NA-NA

Author(s):

J. M. O'Brien ◽

J R. Barton ◽

S. A. Shumate ◽

S. L. Satchwell ◽

D. A. Milligan

Keyword(s):

Platelet Count ◽

Regional Anesthesia ◽

Hellp Syndrome ◽

Liver Enzymes ◽

Corticosteroid Administration ◽

Elevated Liver Enzymes ◽

Low Platelet Count ◽

The Impact

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Fetomaternal outcome in pregnancy with HELLP syndrome

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20202722 ◽

2020 ◽

Vol 9 (7) ◽

pp. 2860

Author(s):

Prachi M. Shelat ◽

Rupa C. Vyas ◽

Sapana R. Shah ◽

Naimish D. Nathwani

Keyword(s):

Hellp Syndrome ◽

Liver Enzymes ◽

Care Center ◽

Tertiary Care ◽

Peripheral Blood Smear ◽

Intrauterine Death ◽

Tertiary Care Center ◽

Maternal Complications ◽

Elevated Liver Enzymes ◽

Low Platelet Count

Background: HELLP Syndrome is a serious complication of pregnancy induced hypertensive disorders. It is defined as a triad of hemolysis, elevated liver enzymes, and low platelet count (HELLP). Objectives of this study was to find out incidence of HELLP syndrome in pre-eclampsia, eclampsia and its overall incidence. To analyse the clinical profile of HELLP syndrome. To study maternal and perinatal outcome including morbidity and mortality.Methods: A retrospective study was conducted from July 2017 to September 2019 at a tertiary care center with inclusion criteria of abnormal peripheral blood smear, elevated liver enzymes (LDH, aspartate aminotransferase), and low platelet count.Results: HELLP syndrome was more common in younger age group (45%) and in primigravida (52.5%). Most of the patients presented at >36 weeks of gestation (40%) and most of the patients delivered by caesarean section (67.5%). Maternal complications were acute renal failure (27.5%), DIC (22.5%), maternal mortality (7.5%). Neonatal complications associated were intrauterine death (27.5%), prematurity (25%) and intrauterine growth retardation (15%).Conclusions: Thus, HELLP syndrome requires an early diagnosis and early initiation of treatment at tertiary care center with all the medical facilities available.

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