scholarly journals Surgical outcomes of patients with early cervical cancer treated with radical hysterectomy in a tertiary care hospital

2021 ◽  
Vol 10 (3) ◽  
pp. 960
Author(s):  
Rameshkumar R. ◽  
Namrata Kulkarni ◽  
Anuriti Sharma ◽  
Chaitra Kulkarni
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Radical Hysterectomy ◽  
Surgical Outcomes ◽  
Care Hospital ◽  
Average Hospital ◽  
Prolonged Stay ◽  
Node Metastases ◽  
Early Cervical Cancer

Background: This study was undertaken to evaluate the surgical outcomes of patients with early cervical cancer treated with radical hysterectomy.Methods:  A total of 50 patients who underwent modified radical hysterectomy between April 2006 and April 2016 at Shri Dharmasthala Manjunatheswara medical college and hospital, Dharwad, Karnataka were retrospectively reviewed. The analysis included clinical and pathologic variables including age, tumour size, clinical stage, lymphovascular space involvement, tumour type and grade, lymph node metastases, surgical margin involvement, intraoperative and postoperative complications and pattern of adjuvant therapy were analysed. Results: The median age of the patient who underwent radical hysterectomy was 47.8 years, the mean parity being 3.6. Histologically, the most common type of malignancy encountered was squamous cell carcinoma of the cervix, which occurred in 42 patients (84 %). 8 (16%) showed involvement of 1 or more lymph nodes and evidence of lymphovascular invasion. Involvement of the resected vaginal margins was noted in 11 patients (22%). The average hospital stay was 19.8 days, the prolonged stay resulting from postoperative morbidity. Postoperative concurrent chemoradiation with cisplatin was administered in eight (16%) cases due to pelvic lymph node metastases. Postoperative vaginal brachytherapy was given in 11 (22%) cases because of positive vaginal margins.Conclusions: The present study shows that general gynaecologists with significant experience in general gynaecologic surgery may, with adequate but abbreviated training, become competent in performing a modified radical hysterectomy. 

scholarly journals Clinical Evaluation of Neoadjuvant Chemotherapy Followed by Radical Hysterectomy in the Management of Cervical Cancer Stage IIB

2016 ◽  
Author(s):  
Rizal Sanif
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Node Metastases ◽  
Radical Hysterectomy ◽  
Cancer Stage ◽  
Inclusion Criteria ◽  
Term Evaluation ◽  
Node Metastases

Objective: To evaluate the clinical efficacy, operability, radicality, toxicity, and incidence of recurrences of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy (RH) among patients with stage IIB cervical cancer. Method: This is an observational clinical study at Dr. Moh. Hoesin Hospital, Palembang. Data were analyzed from 27 patients who matched the inclusion criteria and underwent 3 cycles of neoadjuvant chemotherapy (NAC) with Paclitaxel (75 mg/m2) in combination with Cisplatin (50 mg/m2) and Docetaxel (75 mg/m2) combined with Carboplatin (300 mg/m2) according to AUC 6, followed by radical hysterectomy from January 2012 until December 2013. Result: The operability rate after NAC was 96.4%. Lymph node metastases were negative in 75% of patients, and we found bilateral lymph node metastases in 14.3% of patients. Parametric infiltrations were negative in 85.7% of the patients, and positive in 14.3% of patients. No vaginal infiltrations were found. As much as 89.3% of the patients did not experience any side effect, while anemia and thrombocytopenia were found in 10.8% of the patients. We found that 7.1% of patients had recurrences within 6 months interval. Conclusion: NAC followed by radical hysterectomy showed significant advantages for patients with stage IIB cervical cancer, with fewer side effects. However, long-term evaluation and a larger number of patients are required to confirm this result. Keywords: cervical cancer, neoadjuvant chemotherapy, radical hysterectomy

scholarly journals Imaging of lymph node metastases in cervical cancer

2008 ◽  
Vol 178 (7) ◽  
pp. 867-869 ◽  
Author(s):  
M. Q. Bernardini ◽  
A. Covens
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Node Metastases

scholarly journals Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours

1994 ◽  
Vol 69 (6) ◽  
pp. 1176-1181 ◽  
Author(s):  
FV Cromme ◽  
PFJ van Bommel ◽  
JMM Walboomers ◽  
MPW Gallee ◽  
PL Stern ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Node Metastases

Sentinel node detection with radiocolloid lymphatic mapping in early invasive cervical cancer

2005 ◽  
Vol 15 (2) ◽  
pp. 273-277 ◽  
Author(s):  
Y. S. Lin ◽  
C. C. Tzeng ◽  
K. F. Huang ◽  
C. Y. Kang ◽  
C. C. Chia ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Node ◽  
Lymph Node Metastases ◽  
Lymphatic Mapping ◽  
Invasive Cervical Cancer ◽  
False Negative ◽  
Sentinel Node Detection ◽  
Sentinel Nodes ◽  
Node Metastases

We assessed the feasibility of sentinel lymph node detection using technicium-99 radiocolloid lymphatic mapping for predicting lymph node metastases in early invasive cervical cancer. Thirty patients with cervical cancer (stages IA2–IIA) underwent preoperative lymphoscintigraphy using technicium-99 intracervical injection and intraoperative lymphatic mapping with a handheld gamma probe. After dissection of the sentinel nodes, the standard procedure of pelvic lymph node dissection and radical hysterectomy was performed as usual. The sentinel node detection rate was 100% (30/30). There were seven (23.3%) cases of microscopic lymph node metastases on pathologic analysis. All of them had sentinel node involvement. Therefore, the sensitivity of sentinel node identification for prediction of lymph node metastases was 100%, and no false negative was found. Preoperative lymphoscintigraphy, coupled with intraoperative lymphatic mapping, located the sentinel nodes accurately in our study patients. This sentinel node detection method appears to be feasible for predicting lymph node metastases

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