scholarly journals Decompressive craniectomy in herpes simplex encephalitis: a case report

2020 ◽  
Vol 8 (7) ◽  
pp. 2705
Author(s):  
Vinit Suri ◽  
Swapnil Jain ◽  
Mohit Kalangi Venkata Naga ◽  
Sudheer Tyagi ◽  
Aditendraditya Singh Bhati ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Intracranial Pressure ◽  
Antiviral Therapy ◽  
Herpes Simplex Encephalitis ◽  
Complete Recovery ◽  
Herpes Simplex Virus 1 ◽  
Decompressive Hemicraniectomy ◽  
Sporadic Encephalitis ◽  
Simplex Virus ◽  
Temporal Lobe Lesions

Herpes Simplex Encephalitis is the commonest form of sporadic encephalitis. Availability of effective antiviral therapy viz Acyclovir has significantly reduced the mortality of Herpes Simplex Encephalitis. Elevated intracranial pressure   resulting in herniation syndromes continues to be an important cause of mortality. Antiviral therapy and medical measures for managing raised intracranial pressure including osmotic diuretics, careful usage of steroids and controlled hyperventilation continue to be the cornerstones in management of these patients. Authors present a 38-year-old male patient with Cerebrospinal fluid Meningo-encephalitic panel positivity for herpes simplex virus 1 and bilateral temporal lobe lesions with secondary decline due to impending herniation syndrome despite osmotic diuretics and steroids with patient survival and complete recovery following decompressive hemicraniectomy.

scholarly journals Intracranial Hemorrhage Complicating Herpes Simplex Encephalitis on Antiviral Therapy: A Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Ghada ElShimy ◽  
Christina Mariyam Joy ◽  
Fred Berlin ◽  
Waleed Lashin
Keyword(s):  
Case Report ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Simplex Encephalitis ◽  
Review Of The Literature ◽  
Common Cause ◽  
The Usa ◽  
Acyclovir Therapy ◽  
Sporadic Encephalitis ◽  
Simplex Virus

Herpes simplex virus (HSV) encephalitis is the most common cause of nonendemic sporadic encephalitis in the USA. Decreased mortality with early treatment with acyclovir has been documented. Although common complications include cortical petechial hemorrhages, frank intracerebral hematomas are considered very rare. Only few cases have been reported in the literature. We report a case of HSV encephalitis complicated by intracerebral hemorrhage 12 days after initiation of acyclovir therapy.

scholarly journals Herpes simplex reactivation following neurosurgery: case report and review of the literature

2019 ◽  
Vol 47 (2) ◽  
pp. E9 ◽  
Author(s):  
Diane C. McLaughlin ◽  
Rebecca L. Achey ◽  
Robert Geertman ◽  
Jonah Grossman
Keyword(s):  
Herpes Simplex ◽  
Antiviral Therapy ◽  
Viral Encephalitis ◽  
Herpes Simplex Encephalitis ◽  
Viral Reactivation ◽  
High Dose ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Direct Nerve ◽  
Simplex Virus

Herpes simplex encephalitis is a common viral encephalitis associated with significant morbidity and mortality if not diagnosed and treated early. Neurosurgery may be an impetus for viral reactivation, either from direct nerve manipulation or high-dose steroids often administered during cases. The authors present the 40th known case of herpes simplex virus (HSV) encephalitis following neurosurgical intervention and review the previously reported cases. In their review, the authors observed positive HSV polymerase chain reaction (PCR), which had initially been negative in several cases. In cases in which there is high suspicion of HSV, it may be prudent to continue antiviral therapy and retest CSF for HSV PCR. Antiviral therapy significantly reduces mortality associated with HSV encephalitis.

Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

1995 ◽  
Vol 53 ◽  
pp. 840-841
Author(s):  
Z. Hong Zhou ◽  
Jing He ◽  
Joanita Jakana ◽  
J. D. Tatman ◽  
Frazer J. Rixon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
3D Structure ◽  
Structure Study ◽  
Herpes Simplex Virus 1 ◽  
Shell Proteins ◽  
Life Threatening ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

Ultraviolet Light Induces Reactivation in a Murine Model of Cutaneous Herpes Simplex Virus-1 Infection¶

2001 ◽  
Vol 74 (1) ◽  
pp. 108 ◽  
Author(s):  
Diane E. Goade ◽  
Robert A. Nofchissey ◽  
Donna F. Kusewitt ◽  
Brian Hjelle ◽  
John Kreisel ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Ultraviolet Light ◽  
Murine Model ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus
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