scholarly journals The correlation of Singh index and cortical thickness index toward bone mineral density in women older than 60 years old with femoral neck fracture

2021 ◽  
Vol 9 (5) ◽  
pp. 1270
Author(s):  
Dwijo Purboyo ◽  
K. G. Mulyadi Ridia ◽  
I. G. N. Wien Aryana ◽  
Putu Astawa ◽  
I. Wayan Suryanto Dusak ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Femoral Neck Fracture ◽  
Cortical Thickness ◽  
Negative Impact ◽  
Proximal Femur Fracture ◽  
Mineral Density ◽  
Female Patients ◽  
Singh Index ◽  
Neck Fracture ◽  
Cortical Thickness Index

Background: Femoral neck fracture is one of the most common fractures in elderly. Proximal femur fracture in elderly patients is considered a severe morbidity which has a negative impact on the life expectancy and quality of life. Aim of this study was to find the correlation of cortical thickness index (CTI) and SI toward bone density (BMD) in female patients over 60 years of age with femoral neck fracture.Methods: This is an observational cross-sectional study. Subjects were selected from Sanglah general hospital outpatient department, Denpasar, Bali during the period October 2020 to January 2021 by inclusion requirements and then randomized into two groups. Data were taken through history taking, physical examination as well as supporting investigations such as contralateral hip joint radiograph and BMD measurements. Statistical analysis was done from those data.Results: It has been obtained that there was a positive correlation of Singh index (SI) and CTI toward BMD. The correlation coefficient (r) between SI and BMD was 0.874 (p=0.000). The r between CTI and BMD was 0.854 (p=0.000). Both variables were significant.Conclusions: There were significantly strong correlations between SI and BMD (r=0.874, p=0.00), also CTI and BMD (r=0.854, p=0.00) in female patients over 60 years of age with femoral neck fracture.

Differential Proteomic Identification and Bioinformatics Analysis of Femoral Neck in Elderly Female Patients with Hyperuricaemia

2021 ◽  
Vol 18 ◽  
Author(s):  
Yingyi He ◽  
Guangming Zhang ◽  
Yuyang Huang ◽  
Qi Li ◽  
Cheng Luo
Keyword(s):  
Femoral Neck ◽  
Femoral Neck Fracture ◽  
Differentially Expressed ◽  
Control Group ◽  
Pathophysiological Mechanism ◽  
Differentially Expressed Proteins ◽  
Mineral Density ◽  
Differentially Expressed Protein ◽  
Peptide Mass ◽  
Neck Fracture

Background: Serum uric acid (UA) is positively correlated with bone mineral density (BMD). However, the mechanism by which serum UA affects BMD remains unclear. Objective: The aim was carried out to search for the functional proteins related to serum UA and femoral neck BMD to better understand the pathophysiological mechanism of osteoporosis. Materials and methods: In this study, patients in the UA group (hyperuricaemia combined with femoral neck fracture) and the control group (normal uricaemia combined with femoral neck fracture) were selected according to the inclusion criteria. Total protein was extracted from the femoral neck of each patient. Fluorescence differential gel electrophoresis was used to separate the total proteins, and the differentially expressed protein spots were detected by image analysis. After enzyme digestion, peptide mass fingerprinting and database searches were performed to identify the differentially expressed proteins. DAVID software and Kyoto Encyclopedia of Genes and Genomes (KEGG) data were used for enrichment analysis of the screened differential proteins. Results: After mass spectrometry and database searching, 66 differentially expressed protein spots were identified between the UA group and the control group. Most differentially expressed proteins functioned in cytoskeleton formation, energy metabolism, or signal transduction. They were mainly involved in 50 biological processes, including peroxisome proliferator-activated receptor (PPAR) signalling and fatty acid metabolism. PPARγ and PLIN1 were subject to Western blotting analysis detection; results were consistent with the Label-Free result. Conclusion: Based on an analysis of the biological information, these proteins may be associated with the incidence and progression of the femoral neck bone tissues of hyperuricaemia patients.

A similar cortical thickness threshold discriminates femoral neck fracture cases from controls in both sexes – ages-reykjavik study

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S89
Author(s):  
F. Johannesdottir ◽  
K.E. Poole ◽  
J. Reeve ◽  
K. Siggeirsdottir ◽  
B. Mogensen ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Femoral Neck Fracture ◽  
Cortical Thickness ◽  
Neck Fracture

scholarly journals Pregnancy-Associated Osteoporosis Presented with Femoral Neck Fracture: A Case Report and Literature Review

2020 ◽  
Vol 9 ◽  
pp. 1750
Author(s):  
Azam Faraji ◽  
Zahra Shomali ◽  
Sedigeh Yoosefi
Keyword(s):  
Femoral Neck ◽  
Femoral Neck Fracture ◽  
Hip Joint ◽  
Compression Fracture ◽  
Rare Condition ◽  
Mineral Density ◽  
Multiple Risk Factors ◽  
Neck Fracture ◽  
25 Hydroxy Vitamin D ◽  
Pregnancy Associated Osteoporosis

Background: Pregnancy-associated osteoporosis (PAO) is a rare condition characterized by reduced bone mineral density during the third trimester or lactation. Multiple risk factors, such as genetic, sedentariness, and 25-hydroxy vitamin D deficiency, are associated with PAO. In the majority of cases, PAO is presented with a compression fracture in vertebras, but in our case, it presented with a fracture of the femoral neck. Case Presentation: A 29-year-old, gravida one woman, developed right hip joint pain during the gestational age 34 weeks who referred to our clinic. Despite conservative management, the pain intensified. The patient delivered a healthy neonate in the 38th week of gestation and afterward underwent magnetic resonance imaging of the pelvic, revealing a bruised bone in the femoral neck. Since she had developed a femoral neck fracture during the postpartum period, she underwent open reduction and fixation of the femoral neck. Dual-energy X-ray absorptiometry (DEXA) revealed osteoporosis of the vertebras and femoral neck. She received calcium supplements and alendronate, and the pain was relieved. On 2-year and 4-year follow-up, she was found to be osteopenic with significant improvement in DEXA indices. Conclusion: PAO is a rare condition among young women. This condition should be kept in mind when hip joint or back pain is encountered during pregnancy. [GMJ.2020;9:e1750] DOI:10.31661/gmj.v9i0.1750

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