EVALUATION FUNCTIONAL OUTCOME OF HELICAL FIXATION PFN A2 IN PROXIMAL FEMUR FRACTURE IN ELDERLY

Background: Intertrochantric fractures are the most frequently operated fractures and has the highest mortality and morbidity rates. Evaluation functional outcome of helical fixation pfn a2 in proximal femur fracture in elderly Methods: Hospital based prospective randomized comparative study conducted on 30 patients with Close stable &unstable intertrochanteric femur fracture. Results: As per HHS, we have found that 76.67% cases (23) under excellent category and 20.00% (6) good and 3.33% (1) fair of HHS. Conclusion: We can conclude that the PROXIMAL FEMORAL NAIL ANTIROTATION2 is after proper training and technique a safe and easy implant option for treatment of complex peritertrochanteric fractures. Keywords: HHS, Femur, fracture

Effect of music on clinical outcome after hip fracture operations (MCHOPIN): study protocol of a multicentre randomised controlled trial

BackgroundPatients undergoing proximal femur fracture surgery are at high risk of postoperative complications, with postoperative delirium occurring in 25%–40% of patients. Delirium has profound effects on patient outcome and recovery, the patient’s family, caregivers and medical costs. Perioperative music has a beneficial effect on eliciting modifiable risk factors of delirium. Therefore, the aim of this trial was to evaluate the effect of perioperative recorded music on postoperative delirium in patients with proximal femur fracture undergoing surgery.Methods and analysisThe Music on Clinical Outcome after Hip Fracture Operations study is an investigator-initiated, multicentre, randomised controlled, open-label, clinical trial. Five hundred and eight patients with proximal femur fracture meeting eligibility criteria will be randomised to the music intervention or control group with concealed allocation in a 1:1 ratio, stratified by hospital site. The perioperative music intervention consists of preselected lists totalling 30 hours of music, allowing participants to choose their preferred music from these lists (classical, jazz and blues, pop and Dutch). The primary outcome measure is postoperative delirium rate. Secondary outcome measures include pain, anxiety, medication requirement, postoperative complications, hospital length of stay and 30-day mortality. A 90-day follow-up will be performed in order to assess nursing home length of stay, readmission rate and functional ability to perform daily living activities. Furthermore, the cost and cost-effectiveness of the music intervention will be assessed. Data will be analysed according to an intention-to-treat principle.Ethics and disseminationThe study protocol has been approved by the Medical Research Ethics Committee Erasmus MC on 8 October 2018 (MEC-2018–110, NL64721.078.18). The trial will be carried out following the Declaration of Helsinki principles, Good Clinical Practice guidelines and Dutch Medical Research Involving Human Subjects Act. Research data will be reported following Consolidated Standards of Reporting Trials guidelines and study results will be published in a peer-reviewed journal.Trial registration numberNTR7036.

Early Surgery with Neuraxial Anaesthesia in Patients on Chronic Antiplatelet Therapy with a Proximal Femur Fracture: Multicentric Randomised Clinical Trial

Background: Patients with proximal femur fracture on antiplatelet treatment benefit from early surgery. Our goal was to perform early surgery under neuraxial anaesthesia when indicated by the platelet function test. Methods: We conducted a multicentre randomised open-label parallel clinical trial. Patients were randomised to either early platelet function-guided surgery (experimental group) or delayed surgery (control group). Early surgery was programmed when the functional platelet count (as measured by Plateletworks) was >80 × 109/L. The primary outcome was the emergency admission-to-surgery interval. Secondary outcomes were platelet function, postoperative bleeding, medical and surgical complications, and mortality. Results: A total of 156 patients were randomised, with 78 in each group, with a mean (SD) age of 85.96 (7.9) years, and 67.8% being female. The median (IQR) time to surgery was 2.3 (1.5–3.7) days for the experimental group and 4.9 (4.4–5.6) days for the control group. One-third of patients did not achieve the threshold functional platelet count on the first day of admission, requiring more than one test. There was no difference in clinical outcomes between groups. Conclusions: A strategy individualised according to the platelet function test shortens the time to proximal femur fracture surgery under neuraxial anaesthesia in patients on chronic antiplatelet treatment. Better powered randomised clinical trials are needed to further evaluate the clinical impact and safety of this strategy.

Development of 30-day mortality forecast model in patients after surgical treatment of proximal hip fracture

Introduction Fractures of the proximal femur often occur in elderly and senile patients. Most of them have an unfavorable comorbid background. In this regard, there is a high risk of complications in the postoperative period, which requires the development and implementation of an effective forecasting model in clinical practice designed to take measures to avoid adverse treatment outcomes.Objective To develop a regression model to predict the probability of lethal outcome within 30 days after surgery in patients with proximal femur fracture.Material and Methods A retrospective analysis of inpatient case histories of all patients (n = 1222) with proximal femur fracture treated in our hospital in 2018-2019 was performed. A total of 388 cases were selected for the study.Results After a detailed statistical analysis of the physiological parameters of the patients, four independent factors were identified that increased the risk of death during 30 days following surgery: albumin less than 30 g / l (regression coefficient – 1.742; OR – 5.708, 95% CI – 1.904–17.114, p = 0.002), the presence of diabetes mellitus (regression coefficient – 1.141; OR – 3.130, 95% CI –1.022–9.588, p = 0.046), the presence of acute renal injury (regression coefficient – 3.141; OR – 23.136, 95% CI – 3.886–137.735, p = 0.001), the presence of pneumonia (regression coefficient – 2.130; OR – 8.411, 95% CI – 2.453–28.838, p = 0.001). A regression model for predicting 30-day mortality was developed: the constant regression coefficient was 4.371, the area under the ROC-curve corresponding to the probability of 30-day mortality was 0.841 with 95% CI: 0.732–0.951, model sensitivity and specificity – 78.9 and 81.2%, respectively. After a detailed statistical analysis of the patients' physiological parameters, four independent factors were identified that increase the risk of fatal outcome during the next 30 days after surgery: albumin less than 30 g / l (regression coefficient, 1.742; OR – 5.708, 95% CI (1.904 – 17.114), p = 0.002), presence of diabetes mellitus (regression coefficient – 1.141; OR – 3.130, 95% CI (1.022 – 9.588), p = 0.046), presence of acute renal injury (regression coefficient – 3.141; OR – 23.136, 95% CI (3.886 – 137.735), p = 0.001), presence of pneumonia (regression coefficient – 2.130; OR – 8.411, 95% CI (2.453 – 28.838), p = 0.001). Thereby we developed a regression model to predict 30-day mortality: regression coefficient of the constant was 4.371; area under the ROC curve, corresponding to the dependence of the probability of 30-day mortality, was 0.841 with 95% CI (0.732 – 0.951); model sensitivity and specificity were 78.9 and 81.2%, respectively.Conclusion Aregression model for predicting mortality in patients with proximal femur fractures based on independent risk factors has a sufficient level of sensitivity and specificity. Its application is possible in practical health care institutions, where patients with trauma are treated.