scholarly journals Response of osteoarthritis biomarkers after a rehabilitation program: study protocol

2020 ◽  
Vol 7 (1) ◽  
pp. 35
Author(s):  
Eliane Antonioli ◽  
Felipe B. D. Oliveira ◽  
Rosana R. Campedelli ◽  
Alessandro R. Zorzi ◽  
Danielli Specialli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Knee Osteoarthritis ◽  
High Mobility ◽  
Rehabilitation Program ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Functional Evaluation ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

<p class="abstract"><strong>Background:</strong> Knee osteoarthritis is a progressive degenerative joint disease and remains a leading cause of pain, physical impairment and decline in health-related quality of life in adults.   Despite its incidence being amongst the highest in chronic diseases, effective biomarkers are not available to assist in its management. The main goal of this study is to identify mediators that serve as biomarkers and investigate if the levels of these biomarkers will be correlated to the efficacy of a rehabilitation program.</p><p class="abstract"><strong>Methods:</strong> This is a prospective cohort study with 65 participants. Patients with mild-to-moderate symptomatic knee osteoarthritis will be recruited. The Rehabilitation Program will consist of three session/week during eight weeks. Assessment about functional evaluation will be performed before and after treatment, using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and EuroQOL-5D (Euro quality of life - five dimension) scales, Visual Analog Scale (VAS), and physical function tests (time up and go, isometric strength testing and kinematic gait analysis). Serum levels of classical pro-inflammatory cytokines, hyaluronan and high mobility group box 1 protein (HMGB-1) will be evaluated. The primary outcome is the change in WOMAC scale from baseline to end. Statistical analyses will be used to determine correlation of physical improvement and serum biomarkers. Adverse events will be monitored throughout the study.</p><p class="abstract"><strong>Conclusions: </strong>This trial expect to study the correlation between the anti-inflammatory effects of rehabilitation program derived factors that may be involved in suppressing cytokine induction via suppressing HMGB-1.</p><p class="abstract"><strong>Trial registration:</strong> Clinicaltrials.gov - NCT02964624.</p>

EFFECTIVENESS OF KNEE BRACES IN THE TREATMENT OF KNEE OSTEOARTHRITIS : AN EVIDENCE BASED CASE REPORT

2021 ◽  
Author(s):  
Muhammad Sobri Maulana
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Knee Osteoarthritis ◽  
Clinical Symptoms ◽  
Physical Symptoms ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Serious Adverse Events ◽  
Knee Braces

Introduction: Osteoasthritis is a degenerative joint disease characterized by boney inflammation. Thetreatment goals are to reduce physical symptoms and to improve quality of life through exercises,biomechanical interventions, and pharmacological management.Objectives: To find out the effectiveness of knee braces compared to no treatment or otherconservative treatment for improving the quality of life in patients with knee osteoarthritis.Methods: Literatures were taken from OVIDMedline®, EBMreviews®, and Cochrane®. Threesystematic reviews were selected and critically appraised using standard criteria for interventionresearch.Results: Two systematic reviews had acceptable validity, while another systematic review neededfurther improvement for the methodological quality. High heterogeneity was shown from all reviews.Knee braces is considered as applicable based on the appraisal. One systematic review did notrecommend the use of knee braces for patients without any specific conditions.Discussion: All results stated that knee braces could improve clinical symptoms and quality of lifewithout any serious adverse events. The superiority of knee braces compared to other conservativetreatment and/or no treatment still remained as a question due to inconclusive evidences. Differenttypes of knee braces showed different effectiveness to different types of osteoarthritis, which may alsocontributed to high heterogeneity.Conclusion: 1) In patients with knee osteoarthritis, the use of knee braces can improve thequality of life. 2) It is inconclusive whether knee braces are more effective to improve thequality of life of patients with knee osteoarthritis compared to other conservative treatment.

scholarly journals Platelet-rich plasma intra-articular injections as an alternative treatment for knee osteoarthritis: a systematic review

2017 ◽  
Vol 10 (19) ◽  
pp. 46-51
Author(s):  
Elena Sîrbu ◽  
Șerban Gligor ◽  
Corina Pantea
Keyword(s):  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Cartilage Degeneration ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Primary Analysis ◽  
Beneficial Effects ◽  
Inappropriate Treatment ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

Abstract Knee osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and hypertrophic lesions of the epiphyseal bone. It is a disabling condition that causes difficulties of locomotion and severe complications in case of inappropriate treatment. There is growing evidence proving the beneficial effects of using platelet-rich plasma (PRP) in the treatment of knee osteoarthritis. The aim of the present paper is to review the recent scientific literature on the treatment of knee osteoarthritis with platelet-rich plasma presenting the current opinion on this subject. Methods: We analys several studies about PRP who were identified using online databases: EBSCO, ScienceDirect, Scopus and PubMed. Results: After the primary analysis we selected a total of 23 relevant studies. The analysis focused on different PRP administration techniques and methods used in knee osteoarthritis. Conclusions: PRP is most widely used in incipient and moderate symptomatic knee osteoarthritis. Most studies show a significant decrease in pain and significant improvement in joint functionality. These results were mostly obtained after a short follow-up period (6 months-1 year) and also this treatment has a small number of side effects.

scholarly journals An anti-inflammatory diet intervention for knee osteoarthritis: a feasibility study

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Indiana Cooper ◽  
Peter Brukner ◽  
Brooke L. Devlin ◽  
Anjana J. Reddy ◽  
Melanie Fulton ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Confidence Interval ◽  
Knee Osteoarthritis ◽  
Drop Out ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee ◽  
Anti Inflammatory ◽  
Dietary Education

Abstract Background Knee osteoarthritis has an inflammatory component that is linked to pain and joint pathology, yet common non-surgical and non-pharmacological interventions (e.g., exercise, calorie restricting diets) do not typically target inflammation. We aimed to evaluate the feasibility of a telehealth delivered anti-inflammatory diet intervention for knee osteoarthritis. Methods This 9-week single-arm feasibility study recruited participants aged 40–85 years with symptomatic knee osteoarthritis (inclusion criteria: average pain ≥4/10 or maximal pain ≥5/10 during past week). All participants received a telehealth-delivered anti-inflammatory dietary education intervention involving 1:1 consultations at baseline, 3- and 6-week follow-up. The diet emphasised nutrient-dense wholefoods and minimally processed anti-inflammatory foods and discouraged processed foods considered to be pro-inflammatory. The primary outcome of feasibility was assessed via: i) eligibility, recruitment and retention rates; ii) self-reported dietary adherence; iii) adverse events; and iv) treatment satisfaction. Post-intervention interviews evaluated the acceptability of the dietary intervention delivered via telehealth. Secondary outcomes included changes in self-reported body mass, Knee injury and Osteoarthritis Outcome Score (KOOS), health-related quality of life (EuroQoL-5D), analgesic use and global rating of change. Worthwhile effects were determined by the minimal detectable change (MDC) for all five KOOS-subscales (pain, symptoms, activities of daily living, sport/recreation, quality of life) being contained within the 95% confidence interval. Results Forty-eight of seventy-three (66%) individuals screened were eligible and 28 enrolled over 2 months (82% female, mean age 66 ± 8 years, body mass index 30.7 ± 4.8 kg.m−2). Six participants withdrew prior to final follow-up (21% drop-out). Of those with final follow-up data, attendance at scheduled telehealth consultations was 99%. Self-reported adherence to diet during the 9-week intervention period: everyday = 27%, most of time = 68% and some of time = 5%. Two minor adverse events were reported. Change scores contained the MDC within the 95% confidence interval for all five KOOS subscales. Suggestions to improve study design and limit drop-out included an initial face-to-face consultation and more comprehensive habitual dietary intake data collection. Conclusion This study supports the feasibility of a full-scale randomised controlled trial to determine the efficacy of a primarily telehealth-delivered anti-inflammatory dietary education intervention in adults with symptomatic knee osteoarthritis. Trial registration ACTRN12620000229976 prospectively on 25/2/2020.

AB0871 Rehabilitation Program Improves Functional Status and Quality of life in Patients with Knee Osteoarthritis

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 1192.1-1192
Author(s):  
R.I. Marcu ◽  
R. Traistaru ◽  
S. Patru ◽  
A.C. Bighea ◽  
R.S. Popescu
Keyword(s):  
Quality Of Life ◽  
Knee Osteoarthritis ◽  
Functional Status ◽  
Rehabilitation Program
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