scholarly journals Evaluate the role of endoscopy and ultrasonography in patients of portal hypertension

2019 ◽  
Vol 6 (6) ◽  
pp. 2646
Author(s):  
Ghanshyam Das ◽  
Shweta Gautam ◽  
Vijay Pal
Keyword(s):  
Portal Hypertension ◽  
Portal Vein ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Portal Vein Obstruction ◽  
Hepatic Portal Vein ◽  
Hepatic Portal ◽  
Severe Grade

Background: Aim of the study was to evaluate the role of endoscopy and ultrasonography in pediatric patients suffering from portal hypertension .subjects: children under 12 years of age hospitalized with any symptom or sign suggestive of portal hypertension.Methods: The study was conducted in 30 children with portal hypertension. They were divided into two groups on the basis of site of lesion: extrahepatic (extra hepatic portal vein obstruction) and intrahepatic (chronic liver diseases).Results: Mean age of children with EHPVO (extra hepatic portal vein obstruction) was 4 years and 4 months while that of children with CLD (chronic liver diseases) mean age was 8 years and 4 months. Endoscopic findings in patients with EHPVO have severe grade of varices as compared to those with CLD. In patients with EHPVO, the most common USG finding was nonvisualisation of the main portal vein or either branch (75-85%). Portal vein cavernoma was seen in 75% of these patients. Portosystemic collaterals were visualized in 23 patients  in which the left gastric collateral (60%) was the most common followed by short gastric collaterals in 11 children (55%).Conclusions: Endoscopy and ultrasonography are new and better modalities to assess the diagnosis and severity of portal hypertension. Extra hepatic portal vein obstruction is the commonest cause followed by intrahepatic obstruction (Chronic liver diseases).

Extra-hepatic portal vein obstruction (EHPVO) in adult patients: Role of congenital or acquired thrombophylic disorders as etiologic factors

2000 ◽  
Vol 32 ◽  
pp. 137
Author(s):  
M. Primignani ◽  
N. De Bortoli ◽  
M. Moia ◽  
P. Bucciarelli ◽  
P. Preatoni ◽  
...  
Keyword(s):  
Portal Vein ◽  
Adult Patients ◽  
Portal Vein Obstruction ◽  
Hepatic Portal Vein ◽  
Hepatic Portal

scholarly journals Growth assessment in children with extra-hepatic portal vein obstruction and portal hypertension

2003 ◽  
Vol 40 (4) ◽  
pp. 247-250 ◽  
Author(s):  
Maria Angela Bellomo-Brandão ◽  
André Moreno Morcillo ◽  
Gabriel Hessel ◽  
Silvia Regina Cardoso ◽  
Maria de Fátima P. C. Servidoni ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Portal Hypertension ◽  
Portal Vein ◽  
Portal Vein Obstruction ◽  
Z Scores ◽  
Hepatic Portal Vein ◽  
The Mean ◽  
Hepatic Portal ◽  
Height For Age ◽  
Weight For Age

BACKGROUND: Several studies carried out to examine the growth of children with extra-hepatic portal vein obstruction and portal hypertension have reported a variety of findings. AIM: To assess anthropometric indices in children with portal hypertension due to extra-hepatic portal vein obstruction and who were treated by endoscopic variceal sclerotherapy. METHODS: Anthropometric data were obtained retrospectively from the medical records of 24 patients who had been followed for 3.8 ± 2.5 years at the Pediatric Gastroenterology Outpatient Clinic of the University Hospital, Campinas, SP, Brazil. The mean Z scores of weight for age, height for age and body mass index at diagnosis and at the last consultation were compared to reference data of the National Center for Health Statistics. The two recordings were compared to assess the long-term effect of the condition. RESULTS: The mean Z scores at diagnosis and at the last follow-up visit were all within normal ranges when compared to the reference population, with the following respective values: weight for age, 0.042 ± 1.09 and 0.132 ± 1.29; height for age, 0.200 ± 1.04 and 0.466 ± 1.24, and body mass index, -0.223 ± 0.98 and -0.198 ± 0.98. In addition, there were no significant differences between the Z score values obtained in the two recordings. CONCLUSION: Portal hypertension due to extra-hepatic portal vein obstruction was not associated with growth impairment in the group of children studied.

scholarly journals A Bypassing Technique for the Remedy of Portal Hypertension through Extra Hepatic Portal Vein Obstruction by CFD Analysis

2019 ◽  
Vol 38 ◽  
pp. 89-104
Author(s):  
Mst Khorseda Atkar ◽  
Md Tajul Islam
Keyword(s):  
Portal Hypertension ◽  
Portal Vein ◽  
Control Volume ◽  
Clinical Signs ◽  
Cfd Analysis ◽  
Main Portal Vein ◽  
Venous Flow ◽  
Portal Vein Obstruction ◽  
Hepatic Portal Vein ◽  
Hepatic Portal

Extra-hepatic portal vein obstruction (EHPVO) is the blockage to the flow of blood in the portal vein before reaches to the liver. EHPVO is the common cause of portal hypertension in children in the most Asian countries. Examination reveals that the presence of block in the main portal vein may be responsible for the shrinkage of vein with manifold pernicious complication. The “shunt” policy is a fruitful source of restoration of the hepatic portal flow. This study shows that a new approach of bypassing (or shunting) to the blocked (thrombosed) region of the portal vein is a significant way of reducing portal hypertension and restoration of blood circulation. We studied EHPVO case through computational fluid dynamics (CFD) analysis by considering partial block formation and side to side shunt scheme inside the main portal vein. The constitutive equation for non-Newtonian fluidand energy equation are solved by control volume technique. Our study reveals that the shunting technique is strongly effective for the reconstitution of portal venous flow to the liver with lower tissue stress and rapid regression of clinical signs of portal hypertension. This new technique may potentially applicable for medication of EHPVO when shunting procedures are indicated. GANIT J. Bangladesh Math. Soc.Vol. 38 (2018) 89-104

Extra-hepatic portal vein obstruction (EHPVO) in adult patients: Role of congenital or acquired thrombophylic disorders as etiologic factors

2000 ◽  
Vol 118 (4) ◽  
pp. A966-A967
Author(s):  
Massimo Primignani ◽  
Nicola De Bortoli ◽  
Marco Moia ◽  
Paolo Bucciarelli ◽  
Paoletta Preattoni ◽  
...  
Keyword(s):  
Portal Vein ◽  
Adult Patients ◽  
Portal Vein Obstruction ◽  
Hepatic Portal Vein ◽  
Hepatic Portal

Role of scavenger receptors in the pathophysiology of chronic liver diseases

2013 ◽  
Author(s):  
Carolina Armengol ◽  
Ramon Bartoli ◽  
Lucia Sanjurjo ◽  
Isabel Serra ◽  
Nuria Amezaga ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Chronic Liver ◽  
Scavenger Receptors ◽  
Chronic Liver Diseases

scholarly journals The Role of the Gut Microbiome in Liver Cirrhosis Treatment

2020 ◽  
Vol 22 (1) ◽  
pp. 199
Author(s):  
Na Young Lee ◽  
Ki Tae Suk
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Liver Fibrosis ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Liver Diseases ◽  
Sclerosing Cholangitis ◽  
Chronic Liver ◽  
Chronic Liver Diseases

Liver cirrhosis is one of the most prevalent chronic liver diseases worldwide. In addition to viral hepatitis, diseases such as steatohepatitis, autoimmune hepatitis, sclerosing cholangitis and Wilson’s disease can also lead to cirrhosis. Moreover, alcohol can cause cirrhosis on its own and exacerbate chronic liver disease of other causes. The treatment of cirrhosis can be divided into addressing the cause of cirrhosis and reversing liver fibrosis. To this date, there is still no clear consensus on the treatment of cirrhosis. Recently, there has been a lot of interest in potential treatments that modulate the gut microbiota and gut-liver axis for the treatment of cirrhosis. According to recent studies, modulation of the gut microbiome by probiotics ameliorates the progression of liver disease. The precise mechanism for relieving cirrhosis via gut microbial modulation has not been identified. This paper summarizes the role and effects of the gut microbiome in cirrhosis based on experimental and clinical studies on absorbable antibiotics, probiotics, prebiotics, and synbiotics. Moreover, it provides evidence of a relationship between the gut microbiome and liver fibrosis.

The Role of Oxidative Stress in Chronic Liver Diseases

2020 ◽  
pp. 13-25
Author(s):  
Devaraj Ezhilarasan ◽  
Shanmugam Rajeshkumar ◽  
Thangavelu Lakshmi
Keyword(s):  
Oxidative Stress ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases

scholarly journals Mitochondrial Roles and Cytoprotection in Chronic Liver Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Davide Degli Esposti ◽  
Jocelyne Hamelin ◽  
Nelly Bosselut ◽  
Raphaël Saffroy ◽  
Mylène Sebagh ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Hepatic Metabolism ◽  
Chronic Liver ◽  
Oxygen Species ◽  
Organelle Biogenesis ◽  
Chronic Liver Diseases ◽  
Chronic Liver Injury ◽  
Promising Therapeutic Target ◽  
Apoptosis And Necrosis

The liver is one of the richest organs in terms of number and density of mitochondria. Most chronic liver diseases are associated with the accumulation of damaged mitochondria. Hepatic mitochondria have unique features compared to other organs' mitochondria, since they are the hub that integrates hepatic metabolism of carbohydrates, lipids and proteins. Mitochondria are also essential in hepatocyte survival as mediator of apoptosis and necrosis. Hepatocytes have developed different mechanisms to keep mitochondrial integrity or to prevent the effects of mitochondrial lesions, in particular regulating organelle biogenesis and degradation. In this paper, we will focus on the role of mitochondria in liver physiology, such as hepatic metabolism, reactive oxygen species homeostasis and cell survival. We will also focus on chronic liver pathologies, especially those linked to alcohol, virus, drugs or metabolic syndrome and we will discuss how mitochondria could provide a promising therapeutic target in these contexts.

Sign in / Sign up

Export Citation Format

Share Document