scholarly journals Clinical study of fungal sinusitis

2018 ◽  
Vol 4 (5) ◽  
pp. 1307 ◽  
Author(s):  
Jyotika Waghray
Keyword(s):  
Fungal Infection ◽  
Aspergillus Fumigatus ◽  
Paranasal Sinuses ◽  
Bacterial Flora ◽  
Nasal Discharge ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
Facial Swelling ◽  
Nose And Paranasal Sinuses ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Fungal sinusitis is a distinct clinical entity characterized by inflammation of the sinus mucosa caused by fungal infection like aspergillus (fumigatus, niger, flavus), mucormycosis, candida (albicans), scedosporium, pencillium. Mostly immunocompromised patients, farmers, garbage cleaners, and patients on prolonged nasal sprays are affected. There are different types of fungal sinusitis: fungal mycetoma, allergic fungal, chronic indolent and fulminant sinusitis having symptoms like chronic headache and facial swelling with visual impairment. Patients have thick purulent nasal discharge, nasal obstruction, epistaxis, cheek swelling and may be polyposis. Resident bacterial flora probably inhibits colonization by fungi through a number of mechanisms. Thus antimicrobial therapy predisposes to both the overgrowth of normal fungal flora, e.g., Candida species, and growth of opportunists like Aspergillus<sup>1</sup>. Allergic fungal rhinosinusitis is the most common entity. Aspergillosis is the most common fungal infection. Of these aspergillus fumigatus is the most common fungal pathogen. Maxillary sinuses are commonly involved.</p><p class="abstract"><strong>Methods:</strong> This is a prospective study carried out at department of otorhinolaryngology at Kunal Institute of Medical Specialities Pvt Ltd. Evaluation by proper history taking and clinical examination after which the patient is selected for nasal swab, culture and sensitivity. Plain x-ray nose and paranasal sinuses. CT scans nose and paranasal sinuses. Diagnostic nasal endoscopy.  </p><p class="abstract"><strong>Results:</strong> Allergic fungal sinusitis was the most common entity found with aspergillosis being the most common organism.</p><p><strong>Conclusions:</strong> Allergic fungal sinusitis was most commonly found in the age group of 20 to 29 years with maxillary sinus most commonly affected. </p>

scholarly journals Study on management of fungal infections of nose and parnasal sinuses

2018 ◽  
Vol 5 (1) ◽  
pp. 45
Author(s):  
Prasad A. Kelkar ◽  
Jyoti V. Hirekerur
Keyword(s):  
Fungal Infection ◽  
Paranasal Sinuses ◽  
Antifungal Agents ◽  
Opportunistic Infections ◽  
Fungal Infections ◽  
Detailed Examination ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
Adequate Dose ◽  
Nose And Paranasal Sinuses

<p class="abstract"><strong>Background:</strong> From last few years, the fungal infection has been increasing due to greatly enhanced international traffic and as opportunistic infections in consequence of use of powerful cytotoxic drugs. The disease invariably occurs in diabetics, usually with ketoacidosis, immune compromised patients. Hence, we planned to undertake the present study to evaluate a standard method of management of fungal infections of nose and paranasal sinuses.</p><p class="abstract"><strong>Methods:</strong> A detailed examination of the nose and pranasal sinuses was carried out in the department of ENT. The patients were continuously monitored with pulse oximetry and ECG monitor. In all patients, nasal endoscopy was performed.  </p><p class="abstract"><strong>Results:</strong> In this study, fungal infections of the nose and paranasal sinuses were found to be common between 20 and 50 years of age. Aspergillosis was the commonest sinonasal fungal infection followed by allergic fungal sinusitis, rhinosporidiosis and mucormycosis.</p><p class="abstract"><strong>Conclusions:</strong> Early detection, proper and adequate dose of antifungal agents, timely surgical intervention in the form of debridement and sphenoethmoidectomy and orbital exenteration improve the survival rate in the disease of sinonasal fungal infections.</p><p> </p>

scholarly journals Fungal sinusitis clinical presentation, latest management: A Review Update

2015 ◽  
Vol 12 (1) ◽  
pp. 16-19
Author(s):  
Bithi Bhowmik
Keyword(s):  
Paranasal Sinuses ◽  
Disease Process ◽  
High Rate ◽  
Fungus Ball ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
Invasive Fungal Sinusitis ◽  
Radiologic Imaging ◽  
Chronic Invasive

Fungal sinusitis is a relatively common, often misdiagnosed disease process involving the paranasal sinuses. It is a serious condition, as certain forms of fungal sinusitis are associated with a high rate of mortality. Successful treatment requires a prompt diagnosis and frequently relies on radiologic imaging, specifically computed tomography (CT) and magnetic resonance (MR) imaging. The classification of fungal sinusitis is ever changing, but under the most current and widely accepted classification fungal sinusitis is broadly categorized as either invasive or noninvasive. Invasive fungal sinusitis is defined by the presence of fungal hyphae within the mucosa, submucosa, bone, or blood vessels of the paranasal sinuses. Invasive fungal sinusitis is subdivided into acute invasive fungal sinusitis, chronic invasive fungal sinusitis, and chronic granulomatous invasive fungal sinusitis. Conversely, noninvasive fungal sinusitis is defined by the absence of hyphae within the mucosal and other tissues of the paranasal sinuses. Noninvasive fungal sinusitis is subdivided into allergic fungal sinusitis and fungus ball (fungal mycetoma).Journal of Science Foundation, 2014;12(1):16-19

scholarly journals Quality of life in patients with fungal infection of nose and paranasal sinuses: A study from North India

2017 ◽  
Vol 33 (4) ◽  
pp. 346
Author(s):  
Tanuja Kaushal ◽  
Nitin Gupta ◽  
Rushi ◽  
Surinder Singhal ◽  
Jagdish Chander ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Fungal Infection ◽  
Paranasal Sinuses ◽  
North India ◽  
Nose And Paranasal Sinuses

Sensitization to recombinant Aspergillus fumigatus allergens in allergic fungal sinusitis

2002 ◽  
Vol 89 (2) ◽  
pp. 203-208 ◽  
Author(s):  
William A. McCann ◽  
Marc Cromie ◽  
Francis Chandler ◽  
Jan Ford ◽  
William K. Dolen
Keyword(s):  
Aspergillus Fumigatus ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis

New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients

2018 ◽  
Vol 44 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Loraine Vatin ◽  
Joanna Vitte ◽  
Thomas Radulesco ◽  
Jean-Baptiste Morvan ◽  
Jean Del Grande ◽  
...  
Keyword(s):  
Prospective Study ◽  
Preoperative Diagnosis ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
A Prospective Study

scholarly journals The Role of CT Scan and Histopathology in Diagnosis of Allergic Fungal Sinusitis

2014 ◽  
Vol 7 (3) ◽  
pp. 117-120
Author(s):  
Bhanu Bhanu Bhardwaj ◽  
Jaskaran Singh Gill ◽  
Tanya Singh
Keyword(s):  
Ct Scan ◽  
Preoperative Diagnosis ◽  
Definitive Diagnosis ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
Diagnostic Modality ◽  
Preoperative Diagnostic ◽  
A Prospective Study ◽  
Histological Verification

ABSTRACT Allergic fungal sinusitis is the disease with emerging incidence in last decade. The diagnosis of AFS requires a combination of clinical, radiographic, microbiological and histopathological information. CT scan findings in AFS are considered important in preoperative diagnosis but definitive diagnosis requires histological verification. The role of CT scan as the preoperative diagnostic modality in AFS has been analyzed in 50 patients in a prospective study conducted at our institute and results have been very assuring. This article will surely satisfy many inquisitive minds about the speculations regarding the diagnosis of AFS. How to cite this article Bhardwaj BB, Gill JS, Singh T. The Role of CT Scan and Histopathology in Diagnosis of Allergic Fungal Sinusitis. Clin Rhinol An Int J 2014;7(3):117-120.

scholarly journals Primary Neoplasms of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in the Dog: A Report of 16 Cases from the Files of the AFIP

1978 ◽  
Vol 15 (1) ◽  
pp. 18-30 ◽  
Author(s):  
A. W. Confer ◽  
A. DePaoli
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Clinical Signs ◽  
Armed Forces ◽  
Undifferentiated Carcinoma ◽  
Nasal Discharge ◽  
Undifferentiated Sarcoma ◽  
Facial Swelling ◽  
Primary Neoplasms ◽  
Degree Of Differentiation

Sixteen cases of primary neoplasms of the nasal cavity, paranasal sinuses and nasopharynx in the dog were reviewed from the files of the Armed Forces Institute of Pathology (AFIP). The mean age of affected dogs was 9.5 years. The presenting clinical signs were epistaxis, nasal discharge or facial swelling. Eleven of the affected dogs were purebred. Three of these were Collies and two German Shepherds. The nasal cavity was involved most often. All neoplasms were malignant (11 carcinomas and five sarcomas), and there was invasion of the adjacent bony structures in most dogs. Tumors were classified according to prominent cell type and degree of differentiation into respiratory epithelial carcinoma (four), adenocarcinoma (one), squamous cell carcinoma (one), muco-epidermoid carcinoma (two), undifferentiated carcinoma (three), chondrosarcoma (three) and undifferentiated sarcoma (two).

scholarly journals Allergic fungal sinusitis - new aspects of clinical features, laboratory diagnosis and therapy

2013 ◽  
Vol 141 (9-10) ◽  
pp. 698-704 ◽  
Author(s):  
Valentina Arsic-Arsenijevic ◽  
Aleksandra Barac ◽  
Marina Pekmezovic ◽  
Rajica Stosovic ◽  
Ivica Pendjer
Keyword(s):  
Paranasal Sinuses ◽  
Immunoglobulin E ◽  
Laboratory Finding ◽  
Periodic Acid ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Mucosal Inflammation ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
Specific Staining ◽  
Allergic Mucin

Allergic fungal sinusitis (AFS) is a chronic non?invasive disease. Hypersensitive immune response is usually initiated by allergens of filamentous fungi Aspergillus, Penicillium, Cladosporium, Fusarium, Bipolaris, Curvularia and Alternaria. AFS is a clinical and immune analogue of the allergic bronchopulmonary aspergillosis (ABPA) as the sinus exudate resembles that of the bronchoalveolar lavage (BAL) in ABPA. Patients with AFS are usually immunocompetent, atopic and males. The most common symptoms are headache, fullness in the paranasal sinuses, and difficult breathing through the nose. Clinically, there is a chronic mucosal inflammation and histopathologic finding shows allergic mucin and eosinophils. Specific staining methods, Gomori?s Methenamine Silver (GMS) or periodic acid?Schiff (PAS), are used for microscopic visualisation of hyphae, which are, in addition to the isolated fungi, most reliable evidence of AFS. Computerized tomography (CT) of paranasal sinuses shows the areas of hyperdensity. In cases where AFS is complicated by the erosion of bone tissue, discontinuation of the sinus bone wall can be seen. Significant laboratory finding, which correlate highly with the AFS, are high immunoglobulin E (IgE) antibodies specific for fungi, detected by the skin prick test or in serum. Treatment is often surgical, and after removal of the allergic mucin, therapy involves oral and nasal corticosteroids, immunotherapy and locally applied antimycotics (with verified fungal etiology). During treatment, the total/specific IgE is monitored - concentration increases with the development of AFS, and decreases during the improvement process. Knowledge of the pathophysiological mechanisms of AFS is scarce, and represents the focus of further research in order to define an optimal diagnostic and therapeutic approach.

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