CT Imaging of Primary Lung Tumours with CT Guided Fine Needle Aspiration Cytology Correlation among Guwahati, Assam Population

2021 ◽  
Vol 8 (31) ◽  
pp. 2855-2864
Author(s):  
Ashok Kumar ◽  
Anil Kumar Geetha Virupakshappa ◽  
Sushma Kenkare Lokanatha
Keyword(s):  
Computed Tomography ◽  
Fine Needle Aspiration ◽  
Histopathological Examination ◽  
False Negative ◽  
Needle Aspiration ◽  
Lung Tumour ◽  
Ct Guided ◽  
Fine Needle ◽  
Lung Tumours ◽  
Neoplastic Lesions

BACKGROUND The primary lung masses (tumours) are those that originate from the lung tissue. Although most primary pulmonary tumours are carcinomas, a large histological spectrum of benign and malignant tumours of the lung exists. Although chest xray is still considered to be the primary imaging modality of lungs, computed tomography (CT) not only shows the segments that are involved but also the extent of involvement. We wanted to study the sensitivity and specificity of CT in the diagnosis of primary neoplastic lesions of lung, study the CT patterns of different histological variants of bronchogenic carcinoma, and correlate CT findings with CT guided fine needle aspiration and cytology (FNAC) findings. METHODS The present descriptive cross-sectional study was conducted among 34 patients suspected clinically of having lung neoplasms, in Gauhati Medical College and Hospital, Guwahati, Assam from December 2010 to November 2011. RESULTS Considering FNAC / histopathological examination (HPE) as the gold standard, the positive predictive value and false negative value of CT scan for diagnosis of neoplastic lesions of lung were 97 % and 3 % respectively, in our study. Among our study population, mean age with lung tumours was 61 years, highest number of cases was seen in the age group of 51 - 60 years (35 %); Males and females affected were 27 (79.41 %), and 7 in number (20.59 %), respectively. CONCLUSIONS CT is more sensitive in the detection of neoplastic lesions of the lung and associated hilar / mediastinal adenopathy than chest roentgenography. CT has a high efficacy in detecting neoplastic lesions of lung, delineating its lobar and segmental anatomy, thereby helping surgical resection of lung. In this study, CT guided FNAC and cytological findings correlated well with CT diagnosis of primary neoplastic lesions of lung. KEYWORDS Primary Lung Tumour, Contrast Enhanced Computed Tomography (CECT), Fine Needle Aspiration and Cytology (FNAC)

scholarly journals Transesophageal endoscopic ultrasound fine needle aspiration of vertebral body osteolytic tumors – a novel diagnostic approach. Case series.

2020 ◽  
Author(s):  
Romeo Ioan Chira ◽  
Alina Florea ◽  
Vlad Ichim ◽  
Liliana Rogojan ◽  
Alexandra Chira ◽  
...  
Keyword(s):  
Vertebral Body ◽  
Endoscopic Ultrasound ◽  
Fine Needle Aspiration ◽  
Histopathological Examination ◽  
Traditional Approach ◽  
Case Series ◽  
Lumbar Vertebrae ◽  
Needle Aspiration ◽  
Ct Guided ◽  
Fine Needle

Aims: Vertebral lesions, either primary or more frequently metastasis, are difficult targets for percutaneous guided biopsies and surgical biopsies and are associated with greater risks of complications. We investigated the feasibility of endoscopic ultrasound (EUS) fine needle aspiration (FNA) biopsy in the assessment of vertebral osteolytic tumors as an alternative to CT guided biopsy which is the technique currently used.Material and methods: Four patients with osteolytic tumors of the vertebral bodies identified by imaging methods (CT or MRI) – 3 patients, and one with a tumor detected primarily during EUS procedure were included in order to evaluate the feasibility of the procedure. The lesions were located either at the dorsal or lumbar vertebrae. In all cases we performed EUS FNA of the osteolytic vertebral body lesions with 22G needles using the transesophageal or transgastric approach.Results: In all cases EUS FNA provided enough tissue for an accurate histopathological report, with no procedural complication. We diagnosed lung adenocarcinoma, hepatocarcinoma and a pancreatic adenocarcinoma vertebral metastasis and one case of lymphoma.Conclusions: EUS FNA is a valuable technique which should be considered in selected cases, when a “traditional approach” is not applicable or associated with a higher risk. Treatment guidelines are based on the histology of the tumor, histopathological examination being nowadays mandatory. Therefore, we propose for selected cases a feasible technique, with significantly lower procedural risks, as an alternative for open surgical biopsies or computed tomography guided biopsies

scholarly journals The fine-needle aspiration biopsy efficacy of small thyroid nodules in the area of recently normalized iodine supply

2008 ◽  
Vol 159 (6) ◽  
pp. 747-754 ◽  
Author(s):  
Dorota Słowińska-Klencka ◽  
Bożena Popowicz ◽  
Andrzej Lewiński ◽  
Stanisław Sporny ◽  
Mariusz Klencki
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Histopathological Examination ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Iodine Supply ◽  
Needle Aspiration Biopsy ◽  
Thyroid Lesions

ObjectiveTo evaluate the incidence of focal lesions in the thyroid in the area of recently normalized iodine supply as well as to compare the efficacy of fine-needle aspiration biopsy (FNAB) of small (infracentimetric) and large thyroid lesions in this area.MethodsThe outcomes of 13 646 ultrasound (US) examinations, 13 437 US-guided FNABs of the thyroid and 1694 results of post-operative histopathological examinations were analysed.ResultsInfracentimetric nodules (INs ≤10 mm) were revealed by US examinations in 43.5% of patients; in the majority of the cases (82.2%) INs were multiple. The percentage of revealed carcinomas by aspiration of INs is similar to that observed when large nodules (LNs >10 mm) are examined cytologically. However, the efficiency of preoperative diagnosis of INs is lower than LNs with respect to both US selection of lesions for FNAB and the percentage of false negative results of FNAB (29.8 vs 5.4%, P<0.001). In post-operative histopathological examination, extrathyroidal extension of thyroid cancers was observed in nearly 30% of microcarcinomas.ConclusionsIn endemic or post-endemic areas, the efficiency of FNAB is lower in the case of small lesions than larger ones. In spite of this, the percentage of cytologically revealed carcinomas among small lesions is not lower than larger ones. Thus, it is particularly indicated to follow up small thyroid lesions with repeated US examinations in such areas.

scholarly journals Correlation of fine needle aspiration cytology and histopathological examination in thyroid swellings: a prospective study

2019 ◽  
Vol 5 (3) ◽  
pp. 718
Author(s):  
Shenbagavalli S. ◽  
Muthukumar R.
Keyword(s):  
Physical Examination ◽  
Fine Needle Aspiration ◽  
False Positive ◽  
Histopathological Examination ◽  
False Negative ◽  
Needle Aspiration ◽  
Thyroid Function Tests ◽  
Benign Lesions ◽  
Fine Needle ◽  
Positive Results

<p class="abstract"><strong>Background:</strong> Thyroid swellings are not an uncommon condition. Physical examination, laboratory investigation, thyroid imaging, and cytology can be used to evaluate thyroid swellings. After a physical examination, ultrasonography and thyroid function tests, fine needle aspiration (FNA) cytology should be implemented. Although FNA cytology is a common method to evaluate the nodule, false negative and false positive results are not rare. Hence histopathology examination is confirmatory. Information gathered from history, physical examination, ultrasound and intraoperative appearance of thyroid swelling dictate further management. The purpose of the study is to correlate preoperative FNAC and postoperative histopathology in thyroid swellings.</p><p class="abstract"><strong>Methods:</strong> This study of 52 in-patients with thyroid lesions was treated at UIORL-RGGGH MMC Chennai. FNAC and USG were used as preoperative tools for determining the procedure to be performed and was followed by HPE postoperatively for further<strong> </strong>management.  </p><p class="abstract"><strong>Results:</strong> Diagnostic categorization of 52 thyroid swellings were based on FNAC and histopathology. According to FNAC, 88.46% swellings were benign lesions and 11.54% were a malignancy. According to HPE, 82.69% were benign lesions and 17.31% were a malignancy. In our study, the collection of thyroid cases emphasizes the false negativity of FNAC. Cases suspicious of malignancy were decided based on intraoperative changes and were given a note of caution to the pathologists for a meticulous evaluation of slides.</p><p class="abstract"><strong>Conclusions:</strong> FNAC is a simple, safe and cost-effective modality of investigation for thyroid disease but in cases of false negativity histopathology is confirmatory. The false positive results were found to be nil however there is a low percentage of false negative results which has to be confirmed by HPE.</p>

scholarly journals Role of Computed Tomography Guided Fine-Needle Aspiration Cytology in the Study of Various Thoracic Mass Lesions

2021 ◽  
Vol 10 (18) ◽  
pp. 1269-1274
Author(s):  
Nawanita Kumari ◽  
Nidhish Kumar ◽  
Sharvani Singh ◽  
Vishal Vaibhaw
Keyword(s):  
Computed Tomography ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Ct Guided ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Intrathoracic Mass ◽  
Mass Lesions

BACKGROUND Intrathoracic mass is a problem faced by the clinicians worldwide which is difficult to diagnose correctly. The mediastinum although a small anatomic compartment, the pathologic processes found in it are diverse. Imaging techniques are very helpful for detection and diagnosing these lesions. The current study was conducted for assessing the diagnostic accuracy and efficacy of computed tomography (CT) guided fine-needle aspiration cytology (FNAC) in the evaluation of various thoracic mass lesions and also to compare the histopathological findings of CT guided FNAC for evaluation of the type of thoracic lesions & its prognosis. METHODS Data for the study was collected from 50 patients referred to the Department of Pathology, in a tertiary care hospital for 16 months from December 2015 to March 2017. RESULTS Among 50 patients with intrathoracic mass, there were 37 men (74 %) and 13 women (26 %). The age of patients with intrathoracic masses in this study varied from 31 to 80 years. The mean age was 55 years. Thirty-two patients were found to have malignant tumours and 18 cases were of benign aetiology. The highest frequency of cases in this study were of adenocarcinoma followed by squamous cell carcinoma. CONCLUSIONS Computed tomography (CT) guided fine-needle aspiration cytology (FNAC) is a cost effective, simple, safe, highly sensitive & specific procedure with high diagnostic accuracy in the diagnosis of intrathoracic mass lesions. It has few complications, rarely requiring active management. KEY WORDS Intrathoracic Mass, Fine-Needle Aspiration Cytology, Pneumothorax, Pneumonectomy, Thoracic Mass Lesions

scholarly journals Computed Tomography Guided Transthoracic Fine Needle Aspiration Cytology in the Diagnosis of Sonographically Non-Approachable Intrathoracic Masses – A Study of 100 Cases

1970 ◽  
Vol 20 (1) ◽  
pp. 25-31 ◽  
Author(s):  
RN Sarjer ◽  
AF Rabbi ◽  
A Hossain ◽  
MA Quddus ◽  
N Chowdhury ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Ct Guided ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

Objective: To evaluate the diagnostic efficacy of computed tomography (CT) guided transthoracic fine needle aspiration cytology (FNAC) in the diagnosis of intrathoracic masses not approachable by ultrasound. Materials and Methods: CT guided FNAC of intrathoracic masses was done in 100 patients and they were followed up to the final diagnosis. The diagnostic accuracy, sensitivity, specificity, positive and negative predictive values of the procedures were calculated. Results: The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of CT guided transthoracic FNAC were 93.85%, 100%, 96%, 100% & 89.74% respectively for the diagnosis of sonographically nonapproachable malignant intrathoracic masses and 94.29%, 98.46%, 97%%, 97.06% & 96.97% respectively for benign intrathoracic masses. Conclusion: CT guided transthoracic FNAC is a highly sensitive and specific procedure in the diagnosis of intrathoracic masses that are not approachable by ultrasound. Keywords: Computed tomography; Fine needle aspiration cytology; Intrathoracic masses. DOI: http://dx.doi.org/10.3329/jdmc.v20i1.8568 J Dhaka Med Coll. 2011; 20(1) :25-31

scholarly journals Yield of Computed Tomography Guided Fine Needle Aspiration in Diagnosis of Suspected Cases of Lung Cancer: Experience of a Tertiary Care Hospital of North India

2021 ◽  
Vol 6 (3) ◽  
pp. 46-56
Author(s):  
Vipul Kumar ◽  
Rohtash Yadav ◽  
Sushila Verma
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Small Cell ◽  
Active Management ◽  
Ct Guided ◽  
Fine Needle

Background: Lung cancer is the most commonly diagnosed malignancy across the globe. CT guided FNAC of suspicious lung masses is a widely accepted and simple diagnostic method of relatively low cost with minimal complications. Methods: It was a prospective study conducted from February 2018 to February 2019 in PGIMS, Rohtak on thirty two patients of either sex having lung cancer suspected clinically or on Chest X-ray/CT Thorax who were subjected to computed tomography guided fine needle aspiration. Results: Most of the patients (79.98%) were in 41-70 years age group with 81.25% male 18.75% females and M:F 4:1. Mass was located on right side in 59% and on left side in 41% cases. Malignancy was diagnosed in 29(90.62%) cases whereas 3(9.37%) cases were inflammatory. Two patients (6.25%) had small cell carcinoma whereas 26 patients (65.62%) had non-small cell carcinoma. Out of these 26 patients, 14 had squamous cell carcinoma, 9 had adenocarcinoma and 3 had large cell carcinoma. One patient was found to have small round cell tumor. 3 patients (9.37%) had pneumothorax as a complication out of which two required chest tube drainage. Conclusions: CT guided FNAC is a simple, safe, and reliable procedure with high diagnostic accuracy for the diagnosis and sub typing of lung cancer. Though complications are rare, pneumothorax and hemoptysis are occasionally encountered but resolve with active management. Keywords: Lung Cancer; FNAC; CT Guided; Pneumothorax.

scholarly journals Computed tomography guided fine needle aspiration cytology of mass lesions of lung: our experience in a tertiary care hospital

2021 ◽  
Vol 9 (12) ◽  
pp. 3607
Author(s):  
Vidhu Mahajan ◽  
Mansi Sharma ◽  
Jyotsna Suri ◽  
Surinder K. Atri ◽  
Nipun Kalsotra
Keyword(s):  
Computed Tomography ◽  
Cell Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Ct Guided ◽  
Lung Lesions ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background: The present study was undertaken to evaluate the diagnostic usefulness of image guided fine needle aspiration cytology (FNAC) in various lung lesions-both neoplastic and non- neoplastic.Method: This retrospective study (Jan 2016-Dec 2018) included 34 cases of lung lesions with strong probable radiological diagnosis of lung neoplasm. Computed tomography (CT)-guided FNAC was performed and cytological smears were stained with May-Grunwald-Gimesa (MGG) stain and conventional Papanicolaou (Pap) stain.Result: A total of 34 cases of lung masses in our study, included 21 males (61.7%) and 13 females (38.2%). The age interval varied from 15 to 85 years; majority presenting in 6th and 7th decade of age. Smears were broadly categorized into unsatisfactory (n=2;5.88%), benign (n=3;8.82%), suspicious of malignancy (n=2;5.88%) and malignant lesions (n=27;79.41%). Benign category included 2 cases of tuberculosis and 1 case of abscess. Malignant category included the cases, diagnosed as squamous cell carcinoma(n=8); poorly differentiated carcinoma (n=6); small cell carcinoma (n=3); adenoma carcinoma (n=2); primitive neuroectodermal tumor (n=2); non-Hodgkins lymphoma (n=2) and plasmacytoma (n=1). Malignant category also included one case each of Metastatic Adenocarcinoma, adenoid cystic carcinoma, renal cell carcinoma with known primary site of Tumours.Conclusions: CT-guided FNAC is a less expensive, simple, fast, relatively safe and accurate procedure in the diagnosis of difficult lung lesions; the major limitation being the adequacy of the aspirate. 

scholarly journals Computed Tomography Guided Percutaneous Transthoracic Fine Needle Aspiration Cytology in Chest Masses

2008 ◽  
Vol 47 (171) ◽  
Author(s):  
Shiva B Basnet ◽  
G B Thapa ◽  
R Shahi ◽  
M Shrestha ◽  
R Panthi
Keyword(s):  
Computed Tomography ◽  
Chest Pain ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Active Management ◽  
Safe Procedure ◽  
Radiological Findings ◽  
Ct Guided ◽  
Fine Needle

A retrospective, hospital based discriptive study was done to know the pathological spectrum of thoracic lesions and to correlate the radiological findings with cytological findings obtained from computed tomography guided percutaneous transthoracic fine needle aspiration of chest mass. The clinical, radiological and cytological data of 100 patients were studied who underwent CT guided FNAC from May, 2004 to May, 2007. Diagnostic accuracy of FNAC is 82%. Cytological examination showed that 51 cases were malignant and 31 cases were benign. Provisional diagnosis based on radiological findings were 50 and 32 cases of malignant and benign lesions respectively. Sensitivity and specificity, positive and negative predictive value of radiological findings in this study was 88%, 84%, 90% and 81% respectively. Post procedure complication were (a) pneumothorax in two cases and both the cases had to be hospitalized for active management (b) minimal perilesional hemorrhage and hemoptysis in three cases and (c) chest pain in six cases. CT guided FNAC is a simple and safe procedure with high diagnostic accuracy in the evaluation of focal chest lesions. Pneumothorax, perilesional hemorrhage, hemoptysis and chest pain are the usually encountered complications. Very few cases of complication require active managementJNMA J Nepal Med Assoc. 2008 Jul-Sep;47(171):123-127.

Combined Ct-Guided Biopsy and Cytology in Diagnosis of Bony Lesions

1992 ◽  
Vol 33 (3) ◽  
pp. 225-229 ◽  
Author(s):  
T. Tikkakoski ◽  
S. Lähde ◽  
J. Puranen ◽  
M. Apaja-Sarkkinen
Keyword(s):  
Fine Needle Aspiration ◽  
Bone Biopsy ◽  
False Negative ◽  
Needle Aspiration ◽  
Ct Guided ◽  
Fine Needle ◽  
Negative Results ◽  
Bone Biopsies ◽  
Ct Guided Biopsy ◽  
Bony Lesions

The results of 44 trephine (OD 1.4–4 mm) biopsies and 39 fine needle (0.7–0.9 mm) aspirations of skeletal, mainly vertebral, lesions performed under CT-guidance in 54 patients were evaluated. The fine needle sample was aspirated through the trephine as a complementary procedure in 29 patients and a fine needle aspiration only was performed in 10 patients. Trephine biopsy only was performed in 15 patients. Sufficient material for histologic and cytologic analyses was obtained in 93% (41/44) and 97% (38/39) and a correct benign or malignant diagnosis was obtained in 84% (37/44) and 90% (35/39), respectively. Among the combined examinations the fine needle aspiration alone was diagnostic in 2 cases while the trephine specimen alone provided diagnostic material in 2 cases. In 24 cases both the cytologic and histologic samples were adequate for diagnostic purposes. In one case both methods gave false-negative results. The combined use of cytologic and histologic samples in CT-guided bone biopsies increased diagnostic accuracy. The aorta was perforated once with a 1.4-mm needle but without sequelae. CT-guided bone biopsy was found to be a safe, reliable and cost-efficient method.

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