scholarly journals Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

2020 ◽  
Vol 6 (8) ◽  
pp. 1460
Author(s):  
Prakash Mylanahalli Doddrangaiah ◽  
Bharath Kanna Karunakaran ◽  
Roopa S. Mallali ◽  
Afshan Fathima
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Hard Palate ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumour ◽  
Minor Salivary Glands ◽  
Adenoid Cystic ◽  
Minor Salivary Gland Tumour ◽  
Gland Tumour

<p class="abstract"><strong>Background:</strong> Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.</p><p class="abstract"><strong>Methods:</strong> This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet.  </p><p class="abstract"><strong>Results:</strong> We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).</p><p class="abstract"><strong>Conclusions:</strong> ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.</p>

Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

2012 ◽  
Vol 27 (4) ◽  
pp. 381-388 ◽  
Author(s):  
Mark R. Darling ◽  
Nelly N. Hashem ◽  
Irene Zhang ◽  
Mohamed Mohamed ◽  
Kevin Fung ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumour ◽  
Immunoperoxidase Staining ◽  
Aberrant Expression ◽  
Adenoid Cystic ◽  
Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

scholarly journals Clinicopathological study of minor salivary gland tumour

1970 ◽  
Vol 17 (1) ◽  
pp. 48-52
Author(s):  
Md Shazibur Rashid ◽  
Mohammad Ashequr Rahman Bhuiyan ◽  
Mohammad Shafiqul Islam ◽  
Belayat Hossain Siddiquee
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Hard Palate ◽  
Minor Salivary Gland ◽  
Malignant Tumour ◽  
Histological Type ◽  
Salivary Gland Tumour ◽  
Salivary Gland Neoplasm ◽  
Minor Salivary Gland Tumour ◽  
Gland Tumour

Objectives: To find out the clinicopathological factors of minor salivary gland tumour. Methods: An attempt has been made to explore the relative incidence, clinical presentation, age and sex distribution, histological type, site of involvement of each cases of minor salivary gland tumour. Thirty cases of minor salivary gland tumours were studied. Sampling method was purposive, convenient. Data were collected in a prescribed data sheet from BSMMU, DMCH and BKZMC and SSH, Dhaka, during the period of October 2006 to May 2007. Results: In this series of 30 patients, 20 cases (67%) were found malignant and 10 cases (33%) were benign. Regarding the site of distribution of minor salivary gland tumour, 67% (20) were found in the hard palate, three patients were found in the soft palate, three patients in the check, two in the nasopharynx and two in the alveolar margin. All benign tumours in this series were pleomorphic adenoma. Monomorphic adenoma was not found in any patients. Among malignant tumour adenoid cystic carcinoma was the most common 70% (14). Pleomorphic adenoma was found in 33% (10) of total cases. Muco-epidermoid carcinoma was the 2nd most common malignant tumour 12.5% (4). Carcinoma in pleomorphic adenoma was the least common histological type 6% (2). Conclusion: Early diagnosis and treatment of minor salivary gland tumour is likely to lead to a fair outcome. All patients with swelling in hard palate should be considered as a minor salivary tumour. Sub clinical lymphatic metastasis may occur in malignant cases, so all patients should be referred for radiotherapy following surgery. Distant metastases are also rare in such type of malignancy. Key words: Minor salivary gland; Neoplasm. DOI: 10.3329/bjo.v17i1.7628 Bangladesh J Otorhinolaryngol 2011; 17(1): 48-52

Adenoid Cystic Carcinoma of Lacrimal Gland

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 76-77
Author(s):  
Mohd Athar ◽  
K S Sodhi ◽  
S Kala ◽  
R K Maurya ◽  
S Chauhan ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Natural History ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Hard Palate ◽  
Clinical Course ◽  
Fatal Outcome ◽  
Minor Salivary Glands ◽  
Adenoid Cystic ◽  
History Of

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

scholarly journals Oncocytes in Mucoepidermoid Carcinoma of the Palate: Diagnostic Challenges

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Rammohan Kumar ◽  
Srikant Natarajan ◽  
K.S. Sneha ◽  
Nunna Sai Chitra ◽  
Karen Boaz ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Good Prognosis ◽  
Salivary Gland Tumour ◽  
Diagnostic Workup ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Gland Tumour

The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of the reported cases of OMEC have been histologically of low-grade mucoepidermoid carcinoma with large cystic spaces and good prognosis. In this article, we discuss the differential diagnosis and diagnostic workup of an MEC presenting with oncocytes.

scholarly journals Rehabilitation of an Advanced Case of Adenoid Cystic Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Luiz Evaristo Ricci Volpato ◽  
Lorena Frange Caldas ◽  
Paulo Henrique de Souza Castro ◽  
Artur Aburad de Carvalhosa ◽  
Maria Carmen Palma Faria Volpato ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Adjuvant Treatment ◽  
Minor Salivary Gland ◽  
Histopathological Diagnosis ◽  
Incisional Biopsy ◽  
Prosthetic Rehabilitation ◽  
Advanced Case ◽  
Adenoid Cystic

Adenoid cystic carcinoma is a cancer of the salivary gland that primarily affects the parotid, submandibular, and accessory salivary glands. Its growth is slow and it has infiltrative nature. A 46-year-old female patient coming from the rural area presented a lesion on the palate and reported pain in the region for three years. After incisional biopsy, and histopathological diagnosis of adenoid cystic carcinoma of the cribriform type of minor salivary gland, superior hemimaxillectomy and adjuvant treatment with radiotherapy and maxillofacial prosthetic rehabilitation were performed.

scholarly journals Exérese cirúrgica de adenoma pleomórfico em palato: relato de caso

2020 ◽  
Vol 9 (5) ◽  
pp. 449-452
Author(s):  
Laís Guimarães Pinto ◽  
Nathalia Farias Dantas de Figueiredo ◽  
Thaynara Cavalcante Moreira Romão ◽  
Lucas André Barros Ferreira ◽  
Murilo Quintão dos Santos ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Hard Palate ◽  
Minor Salivary Gland ◽  
Minor Salivary Glands ◽  
Mucin 1 ◽  
Histologic Study ◽  
Clin Pathol ◽  
Minor Salivary Gland Tumors

Introdução: O adenoma pleomórfico (AP) é um tumor de glândulas salivares, misto, benigno composto de células epiteliais e mioepiteliais dispostas em vários padrões morfológicos, demarcadas dos tecidos circundantes por uma cápsula fibrosa. Dentre as glândulas salivares, é predominante nas intraorais com maior frequência no palato. Sua etiopatologia ainda é controversa. Objetivo: Relatar um caso clínico de adenoma pleomórfico localizado em região póstero lateral direito, do palato tratado cirurgicamente. Relato do Caso: Paciente, sexo feminino, 55 anos, foi encaminhada com laudo histopatológico de adenoma pleomórfico. Ao exame físico, foi observou um aumento de volume caracterizado como um nódulo séssil, consistente à palpação, localizado em palato duro direito, com aproximadamente 4cm de extensão em seu maior diâmetro, superfície íntegra, coloração normal e indolor. Ao exame tomográfico, imagem unilocular, bem delimitada, com reabsorção óssea local. Como tratamento, optou-se pela exérese cirúrgica da lesão sob anestesia geral, a qual foi realizada sem intercorrências. Paciente atualmente se encontra com 1 ano de pós-operatório sem sinais de recidiva. Conclusão: O tipo de tratamento descrito apresenta excelente prognóstico, com baixas taxas de recidiva.Descritores: Adenoma Pleomorfo; Cirurgia Bucal; Patologia Bucal.ReferênciasSharma A, Deshmukh S, Shaikh A, Dabholkar J. Pleomorphic adenoma of the minor salivary gland of the cheek. Singapore Med J. 2013;54(9):e183-4. Arumugam P, Christopher PJ, Kumar S, Kengasubbiah S, Shenoy V. Pleomorphic adenoma of the palate: a. case report. Cureus 11(3):e4308.Khan MN, Raza SS, Hussain Zaidi SA, Haq IU, Hussain AK, Nadeem MD, Farid K. Pleomorphic Adenoma Of Minor Salivary Glands. J Ayub Med Coll Abbottabad. 2016;28(3):620-22. Chaturvedi M, Jaidev A, Thaddanee R, Khilnani AK. Large Pleomorphic Adenoma of Hard Palate. Ann Maxillofac Surg. 2018;8(1):124-126.Oliveira LJ, Castro HHO, Leão PLR, Leal RM, Horta MCR, Souza PEA. Tratamento de adenoma pleomórfico em palato: relato de 2 casos e revisão de literatura. Rev Port Estomatol Med Dent Cir Maxilofac. 2016;57(1):55-61.Porto DE, Cavalcante JR, Cavalcante Júnior JR, Costa MCF, Pereira SM. Adenoma Pleomórfico de Parótida – Relato de Caso. Rev cir traumatol buco-maxilo-fac. 2014;14(2):15-18;Melo MNB, Nogueira Neto JN, Souza SR, Dultra FKAA, Dultra JA. Adenoma pleomórfico em lábio superior: Relato de caso. Rev. cir. traumatol. buco-maxilo-fac.2016;16(2):40-3.Erdem MA, Cankaya AB, Güven G, Olgaç V, Kasapoğlu C. Pleomorphic adenoma of the palate. J Craniofac Surg. 2011;22(3):1131-4.Takahashi H, Fujita S, Tsuda N, Tezuka F, Okabe H. Intraoral minor salivary gland tumors: a demographic and histologic study of 200 cases. Tohoku J Exp Med. 1990;161(2):111-28. Loiola RF, Matos FR, Nonaka CFW, Lopes FF, Cruz MCFN. Perfil epidemiológico das neoplasias de glândulas salivares diagnosticadas em São Luís-MA. J Bras Patol Med Lab. 2009;45(5):413-20.Tiago RSL, Castro GA, Ricardo LAC, Bühler RB, Fava AS. Adenoma pleomórfico de parótida: aspectos clínicos, diagnósticos e terapêuticos. Rev Bras Otorrinolaringol. 2003;69(4):485-89.Khan MN, Raza SS, Hussain Zaidi SA, Haq IU, Hussain AK, Nadeem MD, Farid K. Pleomorphic Adenoma Of Minor Salivary Glands. J Ayub Med Coll Abbottabad. 2016;28(3):620-22. Soares AB, Demasi APD, Altemani A, Araújo VC. Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. Histopathology. 2011; 58(3):377-82.Soares AB, Demasi AP, Tincani AJ, Martins AS, Altemani A, de Araújo VC. The increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma. J Clin Pathol. 2012;65(3):272-77.Maia FPA, Oliveira PRK, Santos JVQM, Costa DFN, Andrade ESS. Abordagem minimamente invasiva para tratamento de adenoma pleomórfico em palato: caso clínico. Rev Cir Traumatol Bucomaxilofac. 2019;19(3):21-4.

scholarly journals Adenoid Cystic Carcinoma of Buccal Mucosa: A Rare Presentation

2018 ◽  
Vol 1 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Kumar A ◽  
Garima Rawat ◽  
Gupta S ◽  
Deb S
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Salivary Glands ◽  
Buccal Mucosa ◽  
Minor Salivary Glands ◽  
Rare Presentation ◽  
Adenoid Cystic ◽  
Slow Growing

Adenoid Cystic Carcinoma (ACC) is an unusual slow growing, aggressive neoplasm of salivary gland, constituting less than 1% of all head and neck malignancies. It commonly affects adults in the fourth to sixth decades and typically involves minor salivary glands of palate followed by parotid, and submandibular glands. We present here a case of a 16-year-old female diagnosed with ACC involving the buccal mucosa and abutting the distal end of stenson’s duct along with the surgical management and follow up.

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