Difficulty in establishing a diagnosis in an uncommon presentation of a minor salivary gland tumour

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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Malignant minor salivary gland tumour of the lower lip karapandzic flat reconstruction

British Journal of Oral and Maxillofacial Surgery ◽

10.1016/s0266-4356(96)90346-0 ◽

1996 ◽

Vol 34 (3) ◽

pp. 266-267

Author(s):

M. Rudralingam ◽

G.B. McBride ◽

S. Napier ◽

W.J. Primrose

Keyword(s):

Salivary Gland ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Lower Lip ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

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Clinicopathological study of minor salivary gland tumour

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v17i1.7628 ◽

1970 ◽

Vol 17 (1) ◽

pp. 48-52

Author(s):

Md Shazibur Rashid ◽

Mohammad Ashequr Rahman Bhuiyan ◽

Mohammad Shafiqul Islam ◽

Belayat Hossain Siddiquee

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Hard Palate ◽

Minor Salivary Gland ◽

Malignant Tumour ◽

Histological Type ◽

Salivary Gland Tumour ◽

Salivary Gland Neoplasm ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Objectives: To find out the clinicopathological factors of minor salivary gland tumour. Methods: An attempt has been made to explore the relative incidence, clinical presentation, age and sex distribution, histological type, site of involvement of each cases of minor salivary gland tumour. Thirty cases of minor salivary gland tumours were studied. Sampling method was purposive, convenient. Data were collected in a prescribed data sheet from BSMMU, DMCH and BKZMC and SSH, Dhaka, during the period of October 2006 to May 2007. Results: In this series of 30 patients, 20 cases (67%) were found malignant and 10 cases (33%) were benign. Regarding the site of distribution of minor salivary gland tumour, 67% (20) were found in the hard palate, three patients were found in the soft palate, three patients in the check, two in the nasopharynx and two in the alveolar margin. All benign tumours in this series were pleomorphic adenoma. Monomorphic adenoma was not found in any patients. Among malignant tumour adenoid cystic carcinoma was the most common 70% (14). Pleomorphic adenoma was found in 33% (10) of total cases. Muco-epidermoid carcinoma was the 2nd most common malignant tumour 12.5% (4). Carcinoma in pleomorphic adenoma was the least common histological type 6% (2). Conclusion: Early diagnosis and treatment of minor salivary gland tumour is likely to lead to a fair outcome. All patients with swelling in hard palate should be considered as a minor salivary tumour. Sub clinical lymphatic metastasis may occur in malignant cases, so all patients should be referred for radiotherapy following surgery. Distant metastases are also rare in such type of malignancy. Key words: Minor salivary gland; Neoplasm. DOI: 10.3329/bjo.v17i1.7628 Bangladesh J Otorhinolaryngol 2011; 17(1): 48-52

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Rare Occurrence of Lip Spindle Cell Lipoma

Case Reports in Oncological Medicine ◽

10.1155/2015/382925 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3

Author(s):

Sandra Girgis ◽

Leo Cheng

Keyword(s):

Salivary Gland ◽

Spindle Cell ◽

Minor Salivary Gland ◽

Surgical Excision ◽

Spindle Cell Lipoma ◽

Lower Lip ◽

Salivary Gland Tumours ◽

Minor Salivary Gland Tumour ◽

A Minor ◽

Slow Growing

Spindle cell lipoma (SCL) is a rare distinct variant of lipoma, which presents as a painless, circumscribed, slow-growing, superficial lesion on the lip and can mimic a minor salivary gland tumour. We present a slow growing lower lip lesion and its management.Case Report. A 38-year-old female gave an eight-year history of a slow-growing mass on her lower lip with intermittent change in size. She presented with a submucosal nodule and thin overlying mucosa adjacent to the vermilion border. Surgical excision was carried as the diagnostic and therapeutic approach.Conclusion. Lip SCL is rare, and surgical excision is advocated in order to exclude underlying pathology and minor salivary gland tumours.

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Glycogen-rich clear cell carcinoma in the tongue

The Journal of Laryngology & Otology ◽

10.1017/s0022215100127938 ◽

1994 ◽

Vol 108 (8) ◽

pp. 716-718 ◽

Cited By ~ 17

Author(s):

Esa Rajab ◽

Sharifah Nor Akmal ◽

Abdul Majid Nasir

Keyword(s):

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Minor Salivary Gland ◽

Needle Aspiration ◽

Nodal Metastasis ◽

Needle Aspiration Cytology ◽

Minor Salivary Gland Tumour ◽

A Minor ◽

Gland Tumour

AbstractThe case of a minor salivary gland tumour, arising from the tongue, with nodal metastasis is presented. Biopsy of the tumour and fine-needle aspiration cytology of the neck swelling showed the presence of a clear cell carcinoma with evidence of nodal metastases. A commando operation was performed and the defect was reconstructed using a local tongue flap. The literature review indicated that the neoplasm was rare and its site of occurrence rather unusual.

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Salivary gland tumours: a hospital-based study on demographic and incidence pattern, histopathological types and treatment strategy

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20205062 ◽

2020 ◽

Vol 6 (12) ◽

pp. 2218

Author(s):

M. K. Mili ◽

Hirak Jyoti Das ◽

Asha Saikia ◽

N. J. Saikia ◽

J. Phookan ◽

...

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

Treatment Strategy ◽

Tertiary Care ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Female Ratio ◽

Salivary Gland Tumours ◽

Gland Tumour

Background: Salivary gland tumours constitute 3-4% of all head and neck cancers (mostly benign). These tumours are epithelial (95%) or mesenchymal in origin. Pleomorphic adenoma is the most common benign salivary gland tumour and mucoepidermoid carcinoma (45%) is the most common malignant salivary gland tumour followed by adenoid cystic carcinoma (30%). The parotid, submandibular and the minor salivary glands of palate are commonly involved and the sublingual gland is rarely affected.Methods: Hospital based cross sectional study was done in a tertiary care centre during a period of 1 year, which included 21 patients (10 men and 11 women). Patients were analysed according to age, gender, food habits, histopathological type and site of the tumour and treatment strategy.Results: All the cases were from upper Assam province sharing a particular demographic pattern between 19-65 years. Peak incidence in males was fourth decade and females was third decade. Male female ratio was 0.9:1. Out of 21 cases, 14 were parotid gland tumours, 6 submandibular gland tumours and 1 minor salivary gland tumour. Most of the tumours were benign (16) and 5 were malignant.Conclusions: Two patients were of age 19 years which is conflicting the normal national incidence. All cases belonged to lower economic strata with decreased intake of beta carotene enriched food items. The most common site is parotid gland and most common tumour is pleomorphic adenoma which is in accordance to other studies. Benign cases were subjected to superficial parotidectomy and malignant cases to total parotidectomy with neck dissection.

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A minor salivary gland tumour presenting with dysphagia

The Journal of Laryngology & Otology ◽

10.1017/s0022215100144512 ◽

1999 ◽

Vol 113 (6) ◽

pp. 569-572 ◽

Cited By ~ 6

Author(s):

James Taylor ◽

John V. P. Tighe

Keyword(s):

Minor Salivary Gland ◽

Mass Effect ◽

Pathological Features ◽

Significant Weight Loss ◽

Rare Tumour ◽

Elderly Female ◽

Large Size ◽

Minor Salivary Gland Tumour ◽

A Minor ◽

Gland Tumour

AbstractA case is reviewed of a giant benign myoepithelioma of the soft palate presenting in an elderly female patient. Due to the large size of the lesion and its mass effect the patient developed dysphagia with subsequent significant weight loss. The clinico-pathological features of this rare tumour are described and the literature reviewed.

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Minor salivary gland pleomorphic adenoma - a major tumour in a minor gland

10.26226/morressier.5adde3c3d462b80290b594ad ◽

2018 ◽

Author(s):

Cillian Forde

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Minor Salivary Gland ◽

A Minor

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Sialolithiasis with sialoadenitis of a minor salivary gland

Oral Surgery Oral Medicine Oral Pathology ◽

10.1016/0030-4220(70)90308-7 ◽

1970 ◽

Vol 30 (3) ◽

pp. 320-324 ◽

Cited By ~ 5

Author(s):

Gerald DeGregori ◽

Robert Pippen

Keyword(s):

Salivary Gland ◽

Minor Salivary Gland ◽

A Minor

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Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

The International Journal of Biological Markers ◽

10.5301/jbm.2012.10373 ◽

2012 ◽

Vol 27 (4) ◽

pp. 381-388 ◽

Cited By ~ 5

Author(s):

Mark R. Darling ◽

Nelly N. Hashem ◽

Irene Zhang ◽

Mohamed Mohamed ◽

Kevin Fung ◽

...

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Salivary Gland Tumour ◽

Immunoperoxidase Staining ◽

Aberrant Expression ◽

Adenoid Cystic ◽

Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

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