Evaluation of bone mineral density and its correlation with homocysteine and other biochemical bone markers in postmenopausal women

Background: Osteoporosis is more common in post-menopausal women. Early detection of bone loss by bone mineral density helps to confirm the diagnosis of osteoporosis and assesses the future risk of osteoporotic fractures. Recent studies have revealed the association between increased plasma concentrations of homocysteine (Hcy), and reduced bone mineral density. Nevertheless, inconsistencies persist in the literature. Thus, the need for this study arose to investigate the possible relationship between serum Hcy status and bone mineral density on a group of post-menopausal women. The objective of the study was to assess bone mineral density (BMD) in postmenopausal women and to correlate the same with biochemical bone markers like homocysteine, serum alkaline phosphatase (ALP), calcium and phosphorous levels.Methods: One hundred (100) postmenopausal women were recruited to enter this cross-sectional study. Out of which 86 postmenopausal females, were grouped into osteopenic and osteoporotic based on low t –scores. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry (DEXA) and serum Hcy, serum ALP, calcium and phosphorus levels were estimated. The relationship of Hcy with BMDand other biochemical markers was estimated using Pearson’s correlation.Results: Serum Hcy levels were significantly higher in osteoporotic women when compared to other BMD groups, and were inversely correlated with BMD. No statistical difference was seen with other biochemical bone markers like calcium, Phosphorus and ALP.Conclusions: This study shows that Hcy status is associated with BMD in osteoporotic postmenopausal women. BMD evaluation in postmenopausal women with high Hcy levels may have prognostic and therapeutic potentials, which needs to be explored through further Prospective studies.

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Bone Mineral Density and Biochemical Bone Markers in Postmenopausal Women Following 12 Months of Sublingual Micronized Estrogen and Progesterone Therapy. With and Without the Addition of Micronized Testosterone

Menopause The Journal of The North American Menopause Society ◽

10.1097/00042192-199906040-00118 ◽

1999 ◽

Vol 6 (4) ◽

pp. 357

Author(s):

B E Miller ◽

L C Percival ◽

K L Slade ◽

M J De Souza ◽

A A Luciano

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Bone Markers ◽

Mineral Density ◽

Biochemical Bone Markers

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Bone mineral density and biochemical bone markers in physical active postmenopausal women in HRT

Osteoporosis International ◽

10.1007/bf02500389 ◽

1996 ◽

Vol 6 (S1) ◽

pp. 213-213

Author(s):

J-E. Beck Jensen ◽

G. Kollerup ◽

U. Falktoft ◽

O. H. Sørensen

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Bone Markers ◽

Mineral Density ◽

Biochemical Bone Markers

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Change in Bone Mineral Density in Post Menopausal Women with Rheumatoid Arthritis

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v12i2.14944 ◽

2013 ◽

Vol 12 (2) ◽

pp. 158-163

Author(s):

Mehrdad Aghaei ◽

Sima Sedighi ◽

Naser Behnampour ◽

Sharabeh Hezarkhani ◽

Mona Shirashiani ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Bone Mineral Density ◽

Femoral Neck ◽

Postmenopausal Women ◽

Bone Mineral ◽

Statistical Tests ◽

Mineral Density ◽

Menopausal Women ◽

Duration Of Disease ◽

Post Menopausal

Introduction: Low bone mass is a serious complication of post menopausal women with rheumatoid arthritis. We determined the Change in Bone Mineral Density in postmenopausal women with rheumatoid arthritis. Methods: This retrospective cohort study was carried out on consecutive postmenopausal women with rheumatoid arthritis who were referred to the Azar 5th teaching hospital affiliated to Golestan University of Medical Sciences, North of Iran in 2009. The required data were gathered from the patients medical records. The data were analyzed using SPSS software and statistical tests. Results: We studied 98 postmenopausal women with rheumatoid arthritis. Mean number of years since menopause and mean duration of disease were 9.39 and 5.13 respectively. T Score mean in femoral neck and lumbar spines was -1.45±1.26 and -2.45±1.44 respectively. The overall prevalence of osteoporosis at both the lumbar spine and femoral neck was 13.3. We have found a significant correlation between age, duration of disease, duration of menopause and bone mineral density (P-Value<0.01). Conlusion: Our results indicate a negative effect of age, number of years since menopause and duration of disease on bone mineral density. So, BMD should be measured in high risk women prior to the implementation of any treatment or prevention program. Bangladesh Journal of Medical Science Vol. 12 No. 02 April13 Page 158-163 DOI: http://dx.doi.org/10.3329/bjms.v12i2.14944

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Anti-RANKL therapy—implications for the bone-vascular-axis in CKD? Denosumab in post-menopausal women with low bone mineral density**Comment on McClung MR, Lewiecki EM, Cohen SB et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 2006; 354: 821–831

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfl245 ◽

2006 ◽

Vol 21 (8) ◽

pp. 2075-2077 ◽

Cited By ~ 10

Author(s):

Ralf Westenfeld ◽

Markus Ketteler ◽

Vincent M. Brandenburg

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density ◽

Low Bone Mineral Density ◽

Menopausal Women ◽

Post Menopausal

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Comparison of bone mineral density and serum minerals in pre and post-menopausal women

International Journal of Clinical Trials ◽

10.18203/2349-3259.ijct20151237 ◽

2015 ◽

Vol 2 (4) ◽

pp. 85 ◽

Cited By ~ 1

Author(s):

Sasmita Mishra ◽

M. Manju ◽

B. D. Toora ◽

S. Mohan ◽

B. P. Venkatesh

Keyword(s):

Bone Mineral Density ◽

Bone Mass ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density ◽

T Score ◽

Serum Minerals ◽

Menopausal Women ◽

Post Menopausal ◽

Mineral Levels

Background: Osteoporosis is a disease that weakens bones, increasing the risk of sudden and unexpected fractures. Literally meaning “porous bone”, it results in an increased loss of bone mass and strength. The disease often progresses without any symptoms or pain. Though the exact cause is not known it can be prevented. After age 35, bone breakdown outpaces bone build-up, resulting in a gradual loss of bone mass. Once this loss of bone reaches a certain point, a person has osteoporosis. After menopause, bone resorption (breakdown) outpaces the building of new bone. Osteoporosis is a silent disease, reflected only in a low bone density, till a fracture occurs.One of the most rapidly emerging health problems in the postmenopausal women is osteoporosis. It is now realized that, osteoporotic fractures are a major cause of morbidity and mortality in India in the elderly women population. Aim:To study the correlation between serum minerals and Bone Mineral Density (BMD) in pre and postmenopausal women.Methods: This study was designed to find out the serum mineral levels and its correlation with bone mineral density in pre and post-menopausal women. The present study was a cross-sectional study. 40 women from each group i.e. premenopausal and postmenopausal women were selected for the study with no medical, surgical or gynaecological abnormalities. The Bone Mineral Density (BMD) was measured by Bone Densitometer and classified as normal, osteopenia and osteoporosis according to T-score. Serum minerals were measured in autoanalyser. The data was analyzed using Microsoft excel 2007. For the comparison of values between the groups, students ‘t’ test was used, for the correlation, Pearson’s correlation coefficient was used. Results: Around 80% of the post-menopausal women are osteoporotic. BMD scores were significantly low in postmenopausal women according to T-score along with significantly decreased Serum mineral levels when compared to premenopausal women. There was significant positive correlation between T-score and serum calcium and magnesium levels in postmenopausal women.Conclusions: Our study suggests that peri and postmenopausal women should take magnesium rich foods also like whole grains, legumes, fruits and vegetables (especially dark-green, leafy vegetables) every day which will help to provide recommended intakes of magnesium and maintain normal storage levels of this mineral. If these foods are not available or serum levels are too low supplementation can be given in the form of tablets.

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CORRELATION OF SERUM CHOLESTEROL AND BONE MINERAL DENSITY IN POST MENOPAUSAL WOMEN

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i12.2339 ◽

2021 ◽

Vol 5 (12) ◽

Author(s):

Sawai Singh ◽

Lokesh Soni

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Cholesterol Level ◽

Bone Mineral ◽

Serum Cholesterol ◽

Mineral Density ◽

Menopausal Women ◽

The Mean ◽

Group Ii ◽

Post Menopausal

Background: To find a correlation between serum cholesterol and Bone mineral density in post menopausal women Methods: The study was carried on matched cases and controls. The experimental group consisted of 100 females at postmenopausal age, in which by the DEXA method was diagnosed osteoporosis while the control group consisted of 50 females in a postmenopausal age but without diagnosed osteoporosis who served as controls. Results: Postmenopausal women in the BMI range 18.5 to 25 (normal)were only included in the study. Others were excluded from the study to avoid confounding factors. The mean BMI in women with osteoporosis was 22.13±1.76 and in Group-II was 21.26±2.06. The results were statistically insignificant. Analyzing the average values of serum cholesterol in our study,we found that the mean cholesterol level in group-I was 210.32 ±34.21 mg/dl and 183.21 ±56.32 mg/dl in group-II. The mean cholesterol level was significantly higher in women with osteoporosis. Conclusion: On the decrease in bone mineral density and osteoporosis in postmenopausal women influence many risk factors. Preventive strategies for development of osteoporosis should be initiated in women with elevated serum cholesterol levels. Keywords: Osteoporosis, Menopause, Lipid Profile, BMI.

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