CORRELATION OF SERUM CHOLESTEROL AND BONE MINERAL DENSITY IN POST MENOPAUSAL WOMEN

2021 ◽  
Vol 5 (12) ◽  
Author(s):  
Sawai Singh ◽  
Lokesh Soni
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Cholesterol Level ◽  
Bone Mineral ◽  
Serum Cholesterol ◽  
Mineral Density ◽  
Menopausal Women ◽  
The Mean ◽  
Group Ii ◽  
Post Menopausal

Background: To find a correlation between serum cholesterol and Bone mineral density in post menopausal women Methods: The study was carried on matched cases and controls. The experimental group consisted of 100 females at postmenopausal age, in which by the DEXA method was diagnosed osteoporosis while the control group consisted of 50 females in a postmenopausal age but without diagnosed osteoporosis who served as controls. Results: Postmenopausal women in the BMI range 18.5 to 25 (normal)were only included in the study. Others were excluded from the study to avoid confounding factors. The mean BMI in women with osteoporosis was 22.13±1.76 and in Group-II was 21.26±2.06. The results were statistically insignificant. Analyzing the average values of serum cholesterol in our study,we found that the mean cholesterol level in group-I was 210.32 ±34.21 mg/dl and 183.21 ±56.32 mg/dl in group-II. The mean cholesterol level was significantly higher in women with osteoporosis. Conclusion: On the decrease in bone mineral density and osteoporosis in postmenopausal women influence many risk factors. Preventive strategies for development of osteoporosis should be initiated in women with elevated serum cholesterol levels. Keywords: Osteoporosis, Menopause, Lipid Profile, BMI.

scholarly journals Evaluation of bone mineral density and its correlation with homocysteine and other biochemical bone markers in postmenopausal women

2018 ◽  
Vol 4 (5) ◽  
pp. 709
Author(s):  
Gopinath P. ◽  
Abdul Ravoof
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Markers ◽  
Serum Alkaline Phosphatase ◽  
Plasma Concentrations ◽  
Mineral Density ◽  
Menopausal Women ◽  
Biochemical Bone Markers ◽  
Post Menopausal

<p class="abstract"><strong>Background:</strong> Osteoporosis is more common in post-menopausal women. Early detection of bone loss by bone mineral density helps to confirm the diagnosis of osteoporosis and assesses the future risk of osteoporotic fractures. Recent studies have revealed the association between increased plasma concentrations of homocysteine (Hcy), and reduced bone mineral density. Nevertheless, inconsistencies persist in the literature. Thus, the need for this study arose to investigate the possible relationship between serum Hcy status and bone mineral density on a group of post-menopausal women.<strong> </strong>The objective of the study was to assess bone mineral density (BMD) in postmenopausal women and to correlate the same with biochemical bone markers like homocysteine, serum alkaline phosphatase (ALP), calcium and phosphorous levels.</p><p class="abstract"><strong>Methods:</strong> One hundred (100) postmenopausal women were recruited to enter this cross-sectional study. Out of which 86 postmenopausal females, were grouped into osteopenic and osteoporotic based on low t –scores. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry (DEXA) and serum Hcy, serum ALP, calcium and phosphorus levels were estimated. The relationship of Hcy with BMDand other biochemical markers was estimated using Pearson’s correlation.<strong></strong></p><p class="abstract"><strong>Results:</strong> Serum Hcy levels were significantly higher in osteoporotic women when compared to other BMD groups, and were inversely correlated with BMD. No statistical difference was seen with other biochemical bone markers like calcium, Phosphorus and ALP.</p><p class="abstract"><strong>Conclusions:</strong> This study shows that Hcy status is associated with BMD in osteoporotic postmenopausal women. BMD evaluation in postmenopausal women with high Hcy levels may have prognostic and therapeutic potentials, which needs to be explored through further Prospective studies.</p>

scholarly journals Correlation between Reproductive Hormonal Level and Osteoporosis among Women in Mongolia

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Unentsatsral Lkhagvasuren ◽  
Sarantuya Jav ◽  
Battogtokh Zagdsuren
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Rank Order ◽  
Fragility Fractures ◽  
Serum Estradiol ◽  
Mineral Density ◽  
Serum Lh ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal

Background: Postmenopausal osteoporosis is the most common bone metabolic disease associated with low bone mineral density (BMD) and osteopathic fragility fractures, which can lead to significant morbidity. The objective of this study was to investigate the relationship between serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels and bone mineral density (BMD) across the stages of menopause in Mongolian women.Methods: Two hundred sixty participants aged 50.1±4.4 years were enrolled in the study. Blood samples were obtained from each participant and analyzed using ELISA. Data were first stratified and analyzed by bone mineral density status (osteoporotic, osteopenic, and normal) and then by menopause status. Between group differences were analyzed using t-tests, and correlations were assessed using the Spearman rank order test, with Bonferonni correction. The data were analyzed using Statistical Package Statistical Software version 20.0 (SPSS Inc., Chicago, IL). Significance was set at p<0.05.Results: The mean menopausal age was 48.4±3.4, which is comparable to the Mongolian population mean menopausal age. The mean serum estradiol level in the normal BMD group was 18.3±13.1 pg/ml and  15.8±10.7 pg/ml in the osteoporotic group. The mean serum FSH in the normal BMD group was 54.5±44.1 pg/ml and 81.3±34.2 pg/ml in the osteoporotic group. The mean serum LH level in the normal BMD group was 53.1±41.2 and 75.1±26.1 pg/ml in the osteoporotic group. The mean T and Z score were lower in the osteoporotic group. FSH and LH levels significantly differed across menopause stages in that those who were post-menopausal had higher levels compared to those who were pre- or peri-menopausal. Both hormones, FSH and LH, showed weak negative correlations with BMD level, but not E2. There were significant negative correlations between FSH and Speed of Sound (SOS) (r=-0.16; p<0.01), and  between osteoporosis with age (r=-0.30, p<0.05) and number of childbirths (r=-0.14 p<0.05). Discussion: Osteoporosis is a significant problem with associations to hormone levels in post-menopausal women. In our study, mean serum estradiol levels decreased with age, and the mean FSH and LH levels were higher in women of later menopausal stage. Further study is warranted to investigate the bone related studies to establish better statistical references among Mongolian women. 

scholarly journals Change in Bone Mineral Density in Post Menopausal Women with Rheumatoid Arthritis

2013 ◽  
Vol 12 (2) ◽  
pp. 158-163
Author(s):  
Mehrdad Aghaei ◽  
Sima Sedighi ◽  
Naser Behnampour ◽  
Sharabeh Hezarkhani ◽  
Mona Shirashiani ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Statistical Tests ◽  
Mineral Density ◽  
Menopausal Women ◽  
Duration Of Disease ◽  
Post Menopausal

Introduction: Low bone mass is a serious complication of post menopausal women with rheumatoid arthritis. We determined the Change in Bone Mineral Density in postmenopausal women with rheumatoid arthritis. Methods: This retrospective cohort study was carried out on consecutive postmenopausal women with rheumatoid arthritis who were referred to the Azar 5th teaching hospital affiliated to Golestan University of Medical Sciences, North of Iran in 2009. The required data were gathered from the patients’ medical records. The data were analyzed using SPSS software and statistical tests. Results: We studied 98 postmenopausal women with rheumatoid arthritis. Mean number of years since menopause and mean duration of disease were 9.39 and 5.13 respectively. T Score mean in femoral neck and lumbar spines was -1.45±1.26 and -2.45±1.44 respectively. The overall prevalence of osteoporosis at both the lumbar spine and femoral neck was 13.3. We have found a significant correlation between age, duration of disease, duration of menopause and bone mineral density (P-Value<0.01). Conlusion: Our results indicate a negative effect of age, number of years since menopause and duration of disease on bone mineral density. So, BMD should be measured in high risk women prior to the implementation of any treatment or prevention program. Bangladesh Journal of Medical Science Vol. 12 No. 02 April’13 Page 158-163 DOI: http://dx.doi.org/10.3329/bjms.v12i2.14944

scholarly journals Comparison of bone mineral density and serum minerals in pre and post-menopausal women

2015 ◽  
Vol 2 (4) ◽  
pp. 85 ◽  
Author(s):  
Sasmita Mishra ◽  
M. Manju ◽  
B. D. Toora ◽  
S. Mohan ◽  
B. P. Venkatesh
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
T Score ◽  
Serum Minerals ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Mineral Levels

<p class="abstract"><strong><span lang="EN-US">Background: </span></strong><span lang="EN-GB">Osteoporosis is a disease that weakens bones, increasing the risk of sudden and unexpected fractures. Literally meaning “porous bone”, it results in an increased loss of bone mass and strength. The disease often progresses without any symptoms or pain. Though the exact cause is not known it can be prevented. After age 35, bone breakdown outpaces bone build-up, resulting in a gradual loss of bone mass. Once this loss of bone reaches a certain point, a person has osteoporosis. After menopause, bone resorption (breakdown) outpaces the building of new bone. </span><span lang="EN-US">Osteoporosis is a silent disease, reflected only in a low bone density, till a fracture occurs.</span><span lang="EN-US">One of the most rapidly emerging health problems in the postmenopausal women is osteoporosis. It is now realized that, osteoporotic fractures are a major cause of morbidity and mortality in India in the elderly women population. Aim:</span><span lang="EN-GB">To study the correlation between serum minerals and Bone Mineral Density (BMD) in pre and postmenopausal women.</span></p><p class="abstract"><strong><span lang="EN-US">Methods: </span></strong><span lang="EN-GB">This study was designed to find out the serum mineral levels and its correlation with bone mineral density in pre and post-menopausal women. The present study was a cross-sectional study. 40 women from each group i.e. premenopausal and postmenopausal women were selected for the study with no medical, surgical or gynaecological abnormalities. The Bone Mineral Density (BMD) was measured by Bone Densitometer and classified as normal, osteopenia and osteoporosis according to T-score. Serum minerals were measured in autoanalyser. </span><span lang="EN-US">The data was analyzed using Microsoft excel 2007. For the comparison of values between the groups, students ‘t’ test was used, for the correlation, Pearson’s correlation coefficient was used. </span></p><p class="abstract"><strong><span lang="EN-US">Results: </span></strong><span lang="EN-GB">Around 80% of the post-menopausal women are osteoporotic. BMD scores were significantly low in postmenopausal women according to T-score along with significantly decreased Serum mineral levels when compared to premenopausal women. There was significant positive correlation between T-score and serum calcium and magnesium levels in postmenopausal women.</span></p><p class="abstract"><strong><span lang="EN-US">Conclusions: </span></strong><span lang="EN-GB">Our study suggests that peri and postmenopausal women should take magnesium rich foods also like whole grains, legumes, fruits and vegetables (especially dark-green, leafy vegetables) every day which will help to provide recommended intakes of magnesium and maintain normal storage levels of this mineral. If these foods are not available or serum levels are too low supplementation can be given in the form of tablets.</span></p>

Bio-impedance and quantitative ultrasound to measure bone mineral density in post-menopausal women from a rural Mexican community

2016 ◽  
Author(s):  
Fernando Blanco-Rodriguez ◽  
Nicole Ellis-Infante ◽  
Victor Lopez-Rivas ◽  
Sherlin May-Kim ◽  
Charlotte Pickett ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Quantitative Ultrasound ◽  
Mineral Density ◽  
Menopausal Women ◽  
Mexican Community ◽  
Post Menopausal ◽  
Measure Bone Mineral Density

scholarly journals Physical Activity Level of Post-menopausal Women with Low Bone Mineral Density

2016 ◽  
Vol 38 (05) ◽  
pp. 225-230 ◽  
Author(s):  
Glauber Dallanezi ◽  
Beatriz Freire ◽  
Eliana Nahás ◽  
Jorge Nahás-Neto ◽  
José Corrente ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Physical Activity Level ◽  
Activity Level ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal

Non-weight-bearing effect of trunk and peripheral fat mass on bone mineral density in pre- and post-menopausal women

Maturitas ◽  
2008 ◽  
Vol 60 (3-4) ◽  
pp. 244-247 ◽  
Author(s):  
Akiko Kuwahata ◽  
Yukie Kawamura ◽  
Yukie Yonehara ◽  
Takashi Matsuo ◽  
Ichiro Iwamoto ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Fat Mass ◽  
Weight Bearing ◽  
Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal

Bone mineral density and spongiosa architecture in correlation to vertebral body insufficiency fractures

1998 ◽  
Vol 39 (5) ◽  
pp. 538-542 ◽  
Author(s):  
R. Andresen ◽  
S. Radmer ◽  
D. Banzer
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Vertebral Body ◽  
Unknown Etiology ◽  
Insufficiency Fractures ◽  
Mineral Density ◽  
Group Iii ◽  
Group I ◽  
The Mean ◽  
Group Ii

Objective: the clinical value of spinal quantitative CT (sQCT) and the structural patterns of the vertebral bone were studied Material and Methods: sQCT was performed on 246 patients with a mean age of 57 years for whom conventional lateral radiographies of the thoracic and lumbar spine were available. All patients were suffering from back pain of unknown etiology. the bone mineral density (BMD) of the midvertebral section of 3 lumbar vertebral bodies was determined by means of single-energy-(SE)-weighted QCT (85 kV). Spongiosa architecture and density profile analyses were made in the axial images. This was contrasted to BMD values ascertained in SE QCT. the mean BMD was compared to the number of fractures and the patients were divided into three groups: group I — no fracture; group II — one fracture; and group III 1 fracture Results: the mean BMD was: 134.3 (74.1–187.5) mg hydroxyapatite (HA)/ml in group I; 79.6 (58.6–114.3) mg HA/ml in group II; and 52.4 (13.1–79.1)mg HA/ml in group III. A significant deterioration in spongiosa structure was found with increasing demineralization: strongly rarefied patterns predominated in the fracture groups II and III Conclusion: sQCT provides a good risk assessment of the occurrence of vertebral body insufficiency fractures

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