Role of D- Dimer in aseptic cerebral venous sinus thrombosis

2017 ◽  
Vol 3 (1) ◽  
pp. 16-20
Keyword(s):  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis ◽  
D Dimer

scholarly journals Utility of D-dimer in the diagnosis of cerebral venous sinus thrombosis

2005 ◽  
Vol 3 (2) ◽  
pp. 387-389 ◽  
Author(s):  
B. CUCCHIARA ◽  
S. MESSE ◽  
R. TAYLOR ◽  
J. CLARKE ◽  
E. POLLAK
Keyword(s):  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis ◽  
D Dimer

scholarly journals ChAdOx1 nCOV-19 vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis (CVST)

2021 ◽  
Vol 14 (6) ◽  
pp. e243931
Author(s):  
Preethi Suresh ◽  
William Petchey
Keyword(s):  
Sinus Thrombosis ◽  
External Ventricular Drain ◽  
Intravenous Immunoglobulins ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
High Dose ◽  
Venous Sinus Thrombosis ◽  
Decompressive Craniotomy ◽  
Intracranial Pressures ◽  
D Dimer

A 27-year-old fit and well man presented with intermittent headaches associated with eye floaters and vomiting. His symptoms started 48 hours after having the first dose of ChADOx1 nCOV-19 vaccine (Vaxzevria, previously AstraZeneca COVID-19 vaccine; AstraZeneca) and bloods showed raised D-dimer, low platelets and fibrinogen. CT venogram demonstrated significant cerebral venous sinus thrombosis. He was immediately started on intravenous immunoglobulins and dabigatran after liasing with haematologist. The next day, he complained of worsening headache and new homonymous hemianopia. Repeat CT of the head showed an acute parenchymal bleed with subdural extension and was given idarucizumab and high-dose steroids. He had an emergency decompressive craniotomy and external ventricular drain as his intracranial pressures were difficult to control. Despite full medical and surgical management, his intracranial pressures continued to rise and his brain injury was felt to be too devastating and was deemed unsurvivable.

scholarly journals Cerebral venous sinus thrombosis: Role of extra cranial collateral circulation

2014 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
JigarR Parekh ◽  
Dinesh Khandelwal ◽  
BansiL Kumawat ◽  
ChandramohanB Sharma
Keyword(s):  
Collateral Circulation ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis

scholarly journals HUBUNGAN KADAR D-DIMER DENGAN AWITAN GEJALA DAN LAMA PERAWATAN PADA PENDERITA CEREBRAL VENOUS SINUS THROMBOSIS DI RSUP DR HASAN SADIKIN BANDUNG

2020 ◽  
Vol 37 (2) ◽  
Author(s):  
Lisda Amalia ◽  
Adnin Nugroho
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Length Of Stay ◽  
Computed Tomography Angiography ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis ◽  
D Dimer

CORRELATION BETWEEN D-DIMER LEVEL WITH ONSET OF SYMPTOMS AND LENGTH OF STAY IN CEREBRAL VENOUS SINUS THROMBOSIS PATIENTS AT HASAN SADIKIN HOSPITAL BANDUNGABSTRACTIntroduction:Cerebral venous sinus thrombosis (CVST)is one of a cerebrovascular disease with a diverse and elusive clinical presentation. Diagnosis is often challenging due to limitation in diagnostic tools.Coagulation disorder is one of the risk factor for CVST that can be seen from D-dimer level which tends to increase in CVST patients.Aim: This study aims to determine the D-dimer leveland its correlation with onset of symptoms and length of stay in CVST patients at Hasan Sadikin Hospital, Bandung.Methods: This is a cross-sectional study. The inclusion criteria were patients at Hasan Sadikin Hospital, Bandung diagnosed as CVST, confirmed by digital subtraction angiography (DSA) or computed tomography angiography (CTA) or magnetic resonance angiography (MRA) and had blood coagulation profile in the period of January 2018-May 2019. Exclusion criteria were patients with infection or sepsis. Data were collected from the patient’s medical record. Statistical value was calculated with Spearman rank test, p value<0.05 was considered significant.Results: Forty CVST patients met the criteria. CVST mostly occurred in women (80%), the mean age were 40,75 years, and had headache as primary symptom (70%). Twenty-eight(70%) patients had increased level of D-dimer. D-dimer level had negative correlation with onset of symptoms (r=-0.319, p=0.045). However, it hadassociationwith length of stay (p=0.012).Discussion: D-dimer level in CVST patients tends to increase above normal value. D-dimer level have correlation with onset of symptoms and length of stay in CVST patients.Keywords:Cerebral venous sinus thrombosis, D-dimer level, length of stay, onset of symptomsABSTRAK                          Pendahuluan: Trombosis pada vena serebral (cerebral venous sinus thrombosis/CVST) merupakan salah satu diagnosis dalam bidang cerebrovaskular yang sulit ditegakkan karena keterbatasan alat untuk diagnosis pasti. Salah satu faktor risiko terjadinya CVST adalah kelainan koagulasi yang dapat dilihat dari kadar D-dimer yang cenderung meningkat.Tujuan: Mengetahui gambaran profil D-dimer pada penderita CVST dan hubungannya dengan awitan gejala dan lama perawatan di RSUP Dr. Hasan Sadikin, Bandung.Metode: Penelitian ini merupakan penelitian potong lintang. Kriteria inklusi yaitu pasien yang terdiagnosis CVST melalui pemeriksaan digital substraction angiography (DSA) atau computed tomography angiography (CTA) atau magnetic resonance angiography (MRA) dan memiliki profil koagulasi serta dirawat di RSUP Dr. Hasan Sadikin, Bandung pada periode Januari 2018–Mei 2019. Kriteria eksklusi yaitu pasien yang disertai infeksi atau sepsis. Data diambil dari penelusuran rekam medis pasien dan dianalisis menggunakan korelasi Spearman. Signifikansi dinyatakan bila p<0,05.Hasil: Terdapat 40 pasien CVST yang memenuhi kriteria inklusi. CVST mayoritas terjadi pada perempuan (80%), rerata usia 40,75 tahun dengan keluhan utama tersering adalah nyeri kepala (70%). Terdapat 28 pasien memiliki kadar D-dimer yang meningkat (70%). Berdasarkan analisis, kadar D-dimer memiliki hubungan negatif dengan awitan gejala pasien (r=0,319, p= 0,045). Kadar D-dimer juga memiliki hubungan dengan lama perawatan (p=0,012).Diskusi: Kadar D-dimer pada penderita CVST cenderung lebih tinggi dari nilai normal. Kadar D-dimer memiliki hubungan dengan awitan gejala dan lama perawatan pasien CVST di rumah sakit.Kata kunci: Awitan gejala, cerebral venous sinus thrombosis, kadar D-dimer, lama perawatan

scholarly journals D-Dimer Level with Cerebral Venous Sinus Thrombosis (CVST) Occurrence Using Digital Subtraction Angiography (DSA)

2019 ◽  
Vol 7 (3) ◽  
Author(s):  
Afdi Arahim Putra ◽  
Eppy Buchori ◽  
Hilman Hilman ◽  
Lisda Amalia
Keyword(s):  
Digital Subtraction Angiography ◽  
General Hospital ◽  
Clinical Symptoms ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Digital Subtraction ◽  
Research Subjects ◽  
Venous Sinus Thrombosis ◽  
D Dimer

Cerebral venous sinus thrombosis (CVST) is a cerebrovascular disease in the form of occlusion due to thrombus in the venous and cerebral sinuses. It rarely occurs and has varied clinical symptoms and radiological features and challenging to diagnose. D-dimer used as a diagnostic marker for cases of venous thromboembolism, with a sensitivity of around 90–92%. However, the specificity is not too high (70–73%) because it can also increase in other conditions. Digital subtraction angiography (DSA) is a gold standard examination to establish the diagnosis of CVST. The purpose of this study was to determine the relationship between the D-dimer level and CVST using DSA at Dr. Hasan Sadikin General Hospital in Bandung. This study used an observational analytic method with a case-control study design using retrospective data from medical records at Dr. Hasan Sadikin General Hospital in January 2017–August 2019. The research subjects divided into two groups, namely the high D-dimer levels and the normal/low D-dimer level. Forty people meet the inclusion criteria, ages averaging from 44.77±14.40 years, and consists of 9 male patients (22%) and 31 women patients (78%). For normal/low D-dimer levels 20 patients (50%) and high D-dimer levels 20 patients (50%). Statistical test results measuring D-dimer and CVST levels found a significant relationship (p<0.05). In conclusion, there is a relationship between D-dimer levels with CVST events that have been done by DSA. The higher the D-dimer level, the higher the suspicion of CVST. KADAR D-DIMER DENGAN KEJADIAN CEREBRAL VENOUS SINUS THROMBOSIS (CVST) MENGGUNAKAN DIGITAL SUBTRACTION ANGIOGRAPHY (DSA)Penyakit cerebral venous sinus thrombosis (CVST) merupakan penyakit serebrovaskular berupa oklusi akibat trombus di saluran vena dan sinus serebral yang jarang terjadi dengan gejala klinis dan gambaran radiologis yang bervariasi, serta sangat sulit untuk didiagnosis. D-dimer dapat dijadikan sebagai penanda diagnostik bagi kasus-kasus tromboembolisme vena dengan sensitivitas 90–92%, namun spesifisitasnya tidak terlalu tinggi (70–73%) karena dapat juga meningkat pada kondisi lain. Digital subtraction angiography (DSA) merupakan pemeriksaan baku emas untuk menegakkan diagnosis CVST. Tujuan penelitian ini mengetahui hubungan antara kadar D-dimer dan CVST menggunakan DSA di RSUP Dr. Hasan Sadikin Bandung. Penelitian ini merupakan observasional analitik dengan rancangan kasus kontrol menggunakan data retrospektif dari rekam medis di RSUP Dr. Hasan Sadikin Bandung pada bulan Januari 2017–Agustus 2019. Subjek penelitian dibagi menjadi 2 kelompok, yaitu kelompok D-dimer tinggi dan kelompok D-dimer normal/rendah. Hasil penelitian didapat 40 orang yang memenuhi kriteria inklusi, usia rerata 44,77±14,40 tahun yang terdiri atas pasien laki-laki 9 orang (22%) dan perempuan 31 orang (78%). Untuk kadar D-dimer kategori normal/rendah 20 orang (50%) dan tinggi 20 orang (50%). Hasil uji statistik mengukur kadar D-dimer dan CVST didapatkan hubungan yang bermakna (p<0.05). Simpulan, terdapat hubungan antara kadar D-dimer dan kejadian CVST yang telah dilakukan DSA. Semakin tinggi kadar D-dimer, semakin tinggi kecurigaan kejadian CVST.

The role of decompressive craniectomy in cerebral venous sinus thrombosis

2012 ◽  
Vol 117 (4) ◽  
pp. 738-744 ◽  
Author(s):  
Thanga Thirupathi Rajan Vivakaran ◽  
Dwarakanath Srinivas ◽  
Girish Baburao Kulkarni ◽  
Sampath Somanna
Keyword(s):  
Decompressive Craniectomy ◽  
Sinus Thrombosis ◽  
Univariate Analysis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Self Report ◽  
Venous Sinus Thrombosis ◽  
Poor Outcome ◽  
Gcs Score

Object Studies on the role of decompressive craniectomy for cerebral venous sinus thrombosis (CVST) in the literature are scanty. Randomized trials face a lot of drawbacks, including ethical issues. In this article the authors discuss their experience with this procedure for CVST and review the available literature. Methods This study was a retrospective analysis of all patients who underwent decompressive craniectomy for CVST between August 2006 and June 2008 at the National Institute of Mental Health and Neurosciences. The cases were evaluated for demographic and clinicoradiological features, operative findings, and outcome of surgery. Ethical clearance was obtained from the institutional ethics committee. The data for each patient were obtained from the database of the department. Follow-up data were obtained either through direct clinical evaluation or mailed self-report questionnaire. The Glasgow Outcome Scale (GOS) and the Rankin Disability Scale were used to assess the outcome. Results A total of 34 patients (13 men and 21 women) were included; their mean age was 31.6 years, with a range from 18 to 65 years. In univariate analysis, the Glasgow Coma Scale (GCS) score prior to surgery and that in the immediate postoperative period had a statistically significant correlation with poor outcome. The GCS score immediately postoperatively was the only independent, significant predictor of poor outcome on multivariate analysis. Conclusions Decompressive craniectomy in a selected cohort of patients had a good outcome in a majority of the patients: 26 of 34 in this study had a GOS score of 4 or 5. In this series, which is the largest in the available literature, the authors review their experience and recommend usage of this procedure in selected patients.

Cerebral venous sinus thrombosis in infancy and childhood: role of genetic and acquired risk factors of thrombophilia

1998 ◽  
Vol 157 (7) ◽  
pp. 555-560 ◽  
Author(s):  
H. Vielhaber ◽  
S. Ehrenforth ◽  
H. G. Koch ◽  
I. Scharrer ◽  
N. van der Werf ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis ◽  
Infancy And Childhood

Endovascular Interventional Management of Cerebral Venous Sinus Thrombosis

2018 ◽  
Vol 1 (1) ◽  
pp. 28-33
Author(s):  
Sunil K. Narayan ◽  
Arunmozhimaran Elavarasi
Keyword(s):  
Risk Factors ◽  
Mechanical Thrombectomy ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Endovascular Management ◽  
Venous Sinus Thrombosis ◽  
Endovascular Interventions ◽  
Poor Outcomes

Cerebral venous sinus thrombosis (CVST) is relatively a rare cause of stroke and can have protean manifestations ranging from headache, seizures, diplopia, focal deficits or coma. It is usually managed with anticoagulation. However, various studies have shown a mortality of 13% to 30% and have elucidated certain risk factors such as poor sensorium at presentation and rapid deterioration in spite of anticoagulation, for poor outcomes. In these situations, it has been postulated that endovascular management using thrombolysis or mechanical thrombectomy can give better outcomes. This review tries to address the role of endovascular interventions in CVST.

Role of MRV in Cerebral Venous Sinus Thrombosis

2019 ◽  
Vol 10 (11) ◽  
pp. 3923
Author(s):  
Revathy Pradeep ◽  
W.M.S. Johnson ◽  
Vathsala Venkatasan ◽  
Kavimani
Keyword(s):  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis
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