Adenoid cystic carcinoma of nasal septum: A review of literature

Adenoid cystic carcinoma(ACC) is a common salivary gland tumour which constitutes about 10% of all salivary gland malignancies and 1% of all head & neck malignancies. It is a slow growing tumour with propensity for perineural invasion., It occurs most commonly in minor salivary glands, most commonly in oral cavity. It is the third most common malignancy of paranasal sinuses with most common site being maxillary sinus followed by nasal cavity, nasopharynx and ethmoid sinus. It is most commonly seen in 4 and 5 decade with female predominance. ACC arising from nasal septum is very rare with only 10 cases published in literature. In this paper we present a case of nasal septal adenoid cystic carcinoma with review of the literature.

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Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

The International Journal of Biological Markers ◽

10.5301/jbm.2012.10373 ◽

2012 ◽

Vol 27 (4) ◽

pp. 381-388 ◽

Cited By ~ 5

Author(s):

Mark R. Darling ◽

Nelly N. Hashem ◽

Irene Zhang ◽

Mohamed Mohamed ◽

Kevin Fung ◽

...

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Salivary Gland Tumour ◽

Immunoperoxidase Staining ◽

Aberrant Expression ◽

Adenoid Cystic ◽

Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

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N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Cancers ◽

10.3390/cancers12010045 ◽

2019 ◽

Vol 12 (1) ◽

pp. 45

Author(s):

Candace A. Frerich ◽

Hailey N. Sedam ◽

Huining Kang ◽

Yoshitsugu Mitani ◽

Adel K. El-Naggar ◽

...

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Transcriptional Activity ◽

Perineural Invasion ◽

Salivary Gland Tumor ◽

Rna Seq ◽

Gland Tumor ◽

Adenoid Cystic ◽

Myb Proteins ◽

Tumor Types

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland tumor that frequently displays perineural invasion and is often associated with translocations or overexpression of the MYB oncogene. Detailed analyses of MYB transcripts from ACC patient samples revealed that ACC tumors utilize an alternative MYB promoter, which is rarely used in normal cells or other tumor types. The alternative promoter transcripts produce N-terminally truncated Myb proteins lacking a highly conserved and phosphorylated domain, which includes the pS11 epitope that is frequently used to detect Myb proteins. In RNA-seq assays, Myb isoforms lacking the N-terminal domain displayed unique transcriptional activities, regulating many genes differently than full-length Myb. Thus, a regulatory pathway unique to ACC activates the alternative MYB promoter, leading to the production of a truncated Myb protein with altered transcriptional activities. This could provide new therapeutic opportunities for ACC patients.

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Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203195 ◽

2020 ◽

Vol 6 (8) ◽

pp. 1460

Author(s):

Prakash Mylanahalli Doddrangaiah ◽

Bharath Kanna Karunakaran ◽

Roopa S. Mallali ◽

Afshan Fathima

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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Adenoid Cystic Carcinoma of Buccal Mucosa: A Rare Presentation

Journal of Dental and Maxillofacial Surgery ◽

10.18314/jdms.v1i1.1203 ◽

2018 ◽

Vol 1 (1) ◽

pp. 37-41 ◽

Cited By ~ 1

Author(s):

Kumar A ◽

Garima Rawat ◽

Gupta S ◽

Deb S

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Head And Neck ◽

Salivary Glands ◽

Buccal Mucosa ◽

Minor Salivary Glands ◽

Rare Presentation ◽

Adenoid Cystic ◽

Slow Growing

Adenoid Cystic Carcinoma (ACC) is an unusual slow growing, aggressive neoplasm of salivary gland, constituting less than 1% of all head and neck malignancies. It commonly affects adults in the fourth to sixth decades and typically involves minor salivary glands of palate followed by parotid, and submandibular glands. We present here a case of a 16-year-old female diagnosed with ACC involving the buccal mucosa and abutting the distal end of stenson’s duct along with the surgical management and follow up.

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Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Diagnosed in the Foot

Journal of the American Podiatric Medical Association ◽

10.7547/16-091 ◽

2017 ◽

Vol 107 (5) ◽

pp. 457-460 ◽

Cited By ~ 2

Author(s):

Modupe Agunbiade ◽

Sanaz Lalehparvar ◽

Morteza Khaladj

Keyword(s):

Case Report ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Perineural Invasion ◽

Clinical Presentation ◽

Metastatic Potential ◽

Unique Case ◽

Adenoid Cystic ◽

The Right ◽

Slow Growing

Adenoid cystic carcinoma is a rare, slow-growing neoplasm. It is most commonly located in the salivary glands, affects people older than 55 years of age, and has a predilection for women. These lesions may recur locally but have shown low metastatic potential. We present the unique case of a 71-year-old female with a nonraised hyperpigmented lesion isolated to the right heel. Confusion surrounded the clinical presentation of this dermatologic lesion, and many physicians postulated several differential diagnoses. The purpose of this case report is to bring further awareness to this rare dermatologic variant of adenoid cystic carcinoma, which has been rarely reported in the literature.

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