scholarly journals Excellent outcome of a patient with acute back pain and osteoporotic fracture- A case report

2021 ◽  
Vol 7 (1) ◽  
pp. 50-52
Author(s):  
Subramanian Nallasivan ◽  
Raja S Vignesh ◽  
Arunkumar Govindarajan
Keyword(s):  
Back Pain ◽  
Inflammatory Diseases ◽  
Fragility Fractures ◽  
Multisystem Disease ◽  
Excellent Outcome ◽  
Acute Back Pain ◽  
Surgical Fixation ◽  
Inflammatory Drugs ◽  
Osteoporotic Vertebral Collapse

Rheumatoid arthritis is one of the common inflammatory diseases affecting predominantly women. Steroids and anti-inflammatory drugs have been used for decades in managing this condition. Long term steroids have potentially devastating consequences in any multisystem disease and commonly described side effects include Cushing’s syndrome, diabetes and osteoporosis. Fragility fractures are more common in these patients.We report a patient with back pain and osteoporotic vertebral collapse whose neurological weakness was diagnosed and surgical fixation was done to help the patient improve dramatically. Steroids cause an osteoporotic collapse of the vertebra i.e. fragility fracture and appropriate timely intervention would result in an excellent outcome. Collaboration with other specialists greatly helped to get the treatment early even during this covid pandemic.

STUDY OF SPECIFIC PHARMACOLOGICAL ACTIVITY OF SODIUM SALT (4-О-Β-GLUCOPYRANOSYLOXY)-BENZOIC ACID

2016 ◽  
Vol 78 (6-8) ◽  
Author(s):  
Smirnov Ivan ◽  
Murashko Tatyana ◽  
Ivanov Alex ◽  
Bondarev Alex ◽  
Udut Vladimir
Keyword(s):  
Benzoic Acid ◽  
Analgesic Activity ◽  
Sodium Salt ◽  
Analgesic Effect ◽  
Inflammatory Diseases ◽  
Peptic Ulcers ◽  
Chronic Inflammatory Diseases ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Chronic inflammatory diseases of various genesis are prevalent today. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation, but their long-term use is associated with complications in the gastrointestinal tract, including peptic ulcers. We synthesized a molecule of sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid. This substance has diuretic and anti-inflammatory activities. It should be noted that most of NSAIDs has analgesic effect. In this connection, the aim of this study was to evaluate the analgesic activity of sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid. We studied analgesic effect in the test “acetic writhing”. Sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid significantly reduces the number of writhing by 14 units during the experiment, as an alternative criterion percent of animals with analgesia was 42.6%. Thus, in the test "acetic writhing" revealed the presence of the analgesic activity have developed drug average severity. 

INVESTIGATION OF NEW NSAIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF KIDNEY AND URINARY TRACT

2016 ◽  
Vol 78 (5-6) ◽  
Author(s):  
Murashko Tatyana ◽  
Ivanov Alexey ◽  
Smirnov Ivan ◽  
Bondarev Alex ◽  
Alexey Nemtsev ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
High Efficiency ◽  
Inflammatory Diseases ◽  
Pain Syndrome ◽  
Test Substance ◽  
Peptic Ulcers ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the world, primarily due to their high efficiency for the treatment of inflammatory induced pain syndrome. The main feature of NSAIDs is a combination of anti-inflammatory, analgesic, antipyretic, and anticoagulant properties. However, their long-term use is associated with side effects in the gastrointestinal tract including peptic ulcers and other. We developed and synthesized molecule of methyl (4-О-β-glucopyranosyloxy)-benzoic acid. The anti-inflammatory effect of methyl (4-О-β-glucopyranosyloxy)-benzoic acid evaluated using the carrageenan-induced hindpaw edema model. The study shows that the intragastrically administration of test substance to animals reduces inflammatory process.

scholarly journals Adjunctive therapy for acute musculoskeletal pain

2021 ◽  
Vol 13 (5) ◽  
pp. 102-108
Author(s):  
V. A. Golovacheva ◽  
A. A. Golovacheva
Keyword(s):  
Back Pain ◽  
Musculoskeletal Pain ◽  
Adjunctive Therapy ◽  
Pain Treatment ◽  
B Vitamins ◽  
High Dose ◽  
Lower Back ◽  
Acute Back Pain ◽  
Inflammatory Drugs ◽  
Additional Therapy

Acute musculoskeletal pain (MSP) is one of the leading complaints at patients' admission. Acute MSP is usually localized in the lower back, neck, shoulder girdles, and shins. With an increase in the number of obese and hypodynamic people, the prevalence of MSP increases, especially lower back pain. Treatment of acute MSP in the back consists of informing the patient about a favorable prognosis of the disease, recommendations to maintain daily activity, primary and additional pharmacotherapy. Primary or main pharmacotherapy of acute MSP in the back includes non-steroidal anti-inflammatory drugs (NSAIDs). Adjunctive therapy is usually used in combination with NSAIDs and is aimed to increase the effectiveness of treatment and reduce the duration of NSAIDs use. As an additional therapy, muscle relaxants or B vitamins can be prescribed. The efficacy and safety of combination therapy of NSAIDs and high-dose complexes of B vitamins have been demonstrated in clinical trials involving patients with acute back pain.

scholarly journals A new look at back pain treatment in light of the latest ESCEO guidelines

2020 ◽  
Vol 12 (6) ◽  
pp. 90-95
Author(s):  
O. A. Shavlovskaya ◽  
I. A. Zolotovskaya ◽  
Yu. A. Prokofyeva
Keyword(s):  
Chronic Pain ◽  
Back Pain ◽  
Pain Treatment ◽  
Pain Syndrome ◽  
Modern Medicine ◽  
Economic Aspects ◽  
Immune Disorders ◽  
Inflammatory Drugs ◽  
Disease Modifying

Chronic pain (CP) is still one of the urgent problems of modern medicine. The paper provides a review of the main pharmacotherapeutic approaches from the standpoint of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) guidelines. When preparing this material, the authors have analyzed the publications available in the resources: PubMed, EMBASE, Cochrane, and еLIBRARY. The paper presents the main pathogenetic mechanisms of pain syndrome development in osteoarthritis (OA), including synovial inflammation and associated immune disorders. It considers the types of development of pain syndrome and the main prognostic outcomes according the mechanism of pain, providing a rationale for the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or chondroprotectors (CPs). In accordance with the ESCEO guidelines, it is noted that when starting OA therapy, CPs should be considered as the first step (in their long-term prescription and pharmaceutical quality), then NSAIDs should be added (topically), then (if ineffective) orally, by excluding patients with hip OA. It is known that the intramuscular administration of CPs (chondroitin sulfate (CS) in particular) can increase their bioavailability. The use of glucosamine sulfate (GS) is recommended for patients over 60 years of age. According to the recommendations of the 2019 ESCEO experts, CS and GS should be used as a disease-modifying OA drug from the first step and at all subsequent stages.

scholarly journals Potential analysis for patient education in acute non-specific low back pain / Potenzialanalyse zur Patienten/-innenedukation bei akuten unspezifischen lumbalen Rückenschmerzen

2016 ◽  
Vol 3 (2) ◽  
pp. 107-121
Author(s):  
Adrian Roesner ◽  
Frauke Ackenhausen ◽  
Ralf Eberhardt ◽  
Ulrike Gundlach ◽  
Jonas Marquardt ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Patient Education ◽  
Professional Competence ◽  
Cochrane Review ◽  
Occupational Therapists ◽  
Low Back ◽  
Physically Active ◽  
Inflammatory Drugs

Abstract Health problem Recent health insurance statistics show that low back pain (LBP) takes the first place in individual diagnoses according to sick leave statistics. As stated by the German back pain study of 2003/2006, long-term prevalence amounts to a total of 74 % to 85 %. In the case of acute unspecific LRS guidelines, recommend the use of non-steroidal anti-inflammatory drugs and patient education in order to motivate the patient to retain an active lifestyle, to stay physically active and to inform the patient about the background of the symptoms. Studies about the current medical supply situation in Germany show injections and passive therapy methods are part of the standard care, whereas educational measures are generally not applied. Evidence A Cochrane Review indicates the effectiveness of educational measures that have a duration of 2 hours. Education in the recommended intensity can probably not be realized by health care practitioners within the time framework set aside for treatment and advice. Because of their range of services and their professional competence physical and occupational therapists appear to be predestined for this type of education as intervention. Research recommendations In order to assess the potential of such an intervention for a later more extensive efficacy study a feasibility study should be carried out first. The focus is on assessing the feasibility and the evaluation of intervention education.

scholarly journals Long-term Management of Low Back Pain with Opioids and Non-steroidal Anti-inflammatory Drugs in a Health System

2016 ◽  
Vol 50 (6) ◽  
pp. e191-e193 ◽  
Author(s):  
Brian K. Ahmedani ◽  
Edward L. Peterson ◽  
Karen E. Wells ◽  
Fady Henein ◽  
L. Keoki Williams
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Health System ◽  
Low Back ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Term Management

scholarly journals Adverse effects of spinal manipulation

2000 ◽  
Vol 93 (5) ◽  
pp. 258-259 ◽  
Author(s):  
Ailsa J Barrett ◽  
Alan C Breen
Keyword(s):  
Back Pain ◽  
Adverse Effects ◽  
Spinal Manipulation ◽  
Adverse Reactions ◽  
Acute Back Pain

Summary Guidelines on acute back pain recommend spinal manipulation, but some commentators express concern that the adverse effects are under-reported. Eleven chiropractors distributed questionnaires to 108 consecutive new patients aged >18 years, enquiring about adverse effects one hour, one day and two days after spinal manipulation. The forms were to be completed anonymously. 80 questionnaires (74%) were returned, 68 suitable for analysis. 28 patients reported adverse effects at one hour after treatment, the most common of which were extra pain (14) and radiating pain (9). 8 had reactions beginning the morning after. No serious adverse effects were reported. The adverse reactions, recorded in 53% of respondents, are those to be expected from a treatment that entails initial discomfort. They need to be set against the long-term benefits of spinal manipulation.

scholarly journals The effect of inflammatory response modulator agents on gingivitis and periodontitis

2016 ◽  
Vol 64 (3) ◽  
pp. 312-319
Author(s):  
Juliano CAVAGNI ◽  
Francisco Wilker Mustafa Gomes MUNIZ ◽  
Cassiano Kuchenbecker RÖSING
Keyword(s):  
Host Response ◽  
Animal Studies ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Therapeutic Procedures ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Microbial Challenge

ABSTRACT Periodontal diseases are infecto-inflammatory diseases. Literature, has tried to elucidate the infections component of gingivitis and periodontitis, for several years. In recent years, much has been discussed about the role of the host response modulators to periodontal therapeutic procedures. The aim of the present literature review was to evaluate the effect of host response modulating agents (anti-inflammatories) on the pathogenesis of gingivitis and periodontitis. A search in the main databases was performed and human and animal studies were selected. The majority of studies was performed in humans and non-steroidal anti-inflammatory drugs in different dosages were used. The results have shown a potential benefit of the non-steroidal anti-inflammatory drugs concerning the microbial challenge. However, this benefit seems not to occur in the long term, thus not supporting it as a periodontal therapeutic approach. Few studies evaluated the effect of steroidal anti-inflammatory drugs on the pathogenesis of periodontal diseases. Moreover, the results in humans and animals are controversial, pointing to a possible deleterious effect of steroidal anti-inflammatory drugs on periodontal structures.

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

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