scholarly journals Efficacy of probiotic Lactobacillus reuteri on chronic generalised periodontitis: A systematic review of randomized controlled clinical trials in humans

2021 ◽  
Vol 3 (3) ◽  
pp. 106-117
Author(s):  
Vipin Ahuja ◽  
Annapurna Ahuja
Keyword(s):  
Chronic Periodontitis ◽  
Lactobacillus Reuteri ◽  
Periodontal Diseases ◽  
Data Extraction ◽  
Eligibility Criteria ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Development Of Resistance ◽  
Probiotic Lactobacillus ◽  
Microbiological Parameters

It is well recognized fact that periodontal diseases are caused by multifactorial etiologies; in which microorganisms play an important role. An essential component of therapy is to eliminate or manage these pathogens. This has been traditionally accomplished through mechanical means by scaling and root planning and adjunctive anti-infective therapy, which includes local and systemic antimicrobials. But the unwarranted use of antimicrobial is associated with adverse effects and development of resistance. To overcome these problems newer technologies have been tested in the field of periodontics; one of these therapies is use of probiotic. This approach of therapy is of interest to periodontist due to the aforementioned shortcomings of conventional methods. A manual and electronic search was made for human studies up to November 2020 that presented systemic and local use of probiotics in generalised chronic periodontitis. A systematic approach was followed by two independent reviewers and included eligibility criteria for study inclusion, quality assessment, and determination of outcome measures, data extraction, data synthesis, and drawing of conclusion. Only 3 randomized controlled human trials qualified, and they concluded that use of probiotic Lactobacillus Reuteri proves beneficial in improving clinical and microbiological parameters in generalised chronic periodontitis.

scholarly journals The Efficacy of Acupuncture for Treating Depression-Related Insomnia Compared with a Control Group: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Bo Dong ◽  
Zeqin Chen ◽  
Xuan Yin ◽  
Danting Li ◽  
Jie Ma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Western Medicine ◽  
Acupuncture Treatment ◽  
Meta Analysis ◽  
Alternative Therapy ◽  
Control Group ◽  
Eligibility Criteria ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Hamd Score

Objective.To evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia.Data Source.Seven databases were searched starting from 1946 to March 30, 2016.Study Eligibility Criteria.Randomized-controlled trials of adult subjects (18–75 y) who had depression-related insomnia and had received acupuncture.Results.18 randomized-controlled clinical trials (RCTs) were introduced in this meta-analysis. The findings determined that the acupuncture treatment made significant improvements in PSQI score (MD = −2.37, 95% CI −3.52 to −1.21) compared with Western medicine. Acupuncture combined with Western medicine had a better effect on improving sleep quality (MD = −2.63, 95% CI −4.40 to −0.86) compared with the treatment of Western medicine alone. There was no statistical difference (MD = −2.76, 95% CI −7.65 to 2.12) between acupuncture treatment and Western medicine towards improving the HAMD score. Acupuncture combined with Western medicine (MD = −5.46, CI −8.55 to −2.38) had more effect on improving depression degree compared with the Western medicine alone.Conclusion. This systematic review indicates that acupuncture could be an alternative therapy to medication for treating depression-related insomnia.

scholarly journals A Clinical, Laboratory and Microbiological Evaluation on Efficacy of Dental Air Force Home Dental Cleaning System on Type 2 Diabetic and Nondiabetic Adult Chronic Periodontitis Patients: A 6-Month Clinical Study

2013 ◽  
Vol 2 (1) ◽  
pp. 1-8
Author(s):  
Ameet Madan Mani
Keyword(s):  
Clinical Study ◽  
Air Force ◽  
Chronic Periodontitis ◽  
Clinical Laboratory ◽  
Periodontal Diseases ◽  
Phase 1 ◽  
Cleaning System ◽  
Microbiological Parameters ◽  
Type 2 Diabetic

ABSTRACT Aim The study outlined to evaluate the clinical, laboratory and microbiological efficacy of Dental Air Force home dental cleaning system on type 2 diabetes and nondiabetic adult chronic periodontitis patients. Materials and methods A total of 100 adult chronic periodontitis subjects were recruited voluntary for this study. Clinical [plaque index (PI), gingival index (GI) and clinical attachment loss (CAL)], laboratory (C-reactive protein levels and glycated hemoglobin) and microbiological parameters were measured prior to phase 1 therapy; at 3rd and 6th month post phase 1 therapy. Comparative assessment was done among all the patients that were divided into four groups with Student paired t-test and analysis of variance (ANOVA). Results The results of this study showed that there was significant decrease in clinical, laboratory and microbiological parameters from baseline to 6 months in all the groups (i.e. p < 0.01). The subjects under groups using Dental Air Force home dental cleaning system showed highly significant reduction to all the parameters as compared to subjects under groups using toothbrush. Conclusion There was strong correlation between periodontal diseases and systemic parameters. Dental Air Force home dental cleaning system with the access to interdentally area helps in preventing the accumulation of dental plaque biofilm, thus able to maintain the clinical, laboratory and microbiological parameters at much lower levels as compared to traditional tooth brushing after phase I therapy. How to cite this article Mani S, Mani AM, Saini R. A Clinical, Laboratory and Microbiological Evaluation on Efficacy of Dental Air Force Home Dental Cleaning System on Type 2 Diabetic and Nondiabetic Adult Chronic Periodontitis Patients: A 6-Month Clinical Study. Int J Experiment Dent Sci 2013;2(1):1-8.

scholarly journals Lactobacillus Reuteri DSM 17938 in Infantile Colic: A Systematic Review and Meta-Analysis

2022 ◽  
Vol 6 (3) ◽  
pp. 1446-1454
Author(s):  
Burhannudin Ichsan ◽  
Nining Lestari ◽  
Sulistyani
Keyword(s):  
Systematic Review ◽  
Lactobacillus Reuteri ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Forest Plot ◽  
Infantile Colic ◽  
Eligibility Criteria ◽  
Randomized Controlled ◽  
Infant Colic ◽  
Systematic Synthesis

Background. Infantile colic, defined as paroxysmal, excessive, and consolable crying without an identifiable cause. It is common in the first 3 months of life. There have been many RCT studies conducted. A systematic synthesis is required to summarize the results of these RCTs. This study was aimed to systematically analyze the benefits of Lactobacillus reuteri DSM 17938 for infantile colic. Methods. This systematic review and meta-analysis used keywords: (“infantile colic” OR “abdominal cramps” OR “abdominal cramp” OR “infant colic”) AND “lactobacillus reuteri” AND (placebo OR placebos) AND (“randomized controlled trial” OR RCT). The databases used were: pubmed, science direct, and google scholar. Meta-analysis was conducted to combine the articles. The eligibility criteria were: patient with infantile colic, intervention with L. reuteri DSM 17938, control was placebo, RCT study design, outcome with dichotomous scale, all races, all ethnicities, all countries, all genders, in English, and not limited by year. Results. The search resulted in 800 articles. After reducing duplication, the number of articles was 747. Screening with titles and abstracts resulted in 13 full teks articles. Six articles fitted the eligibility criteria. The results of the meta-analysis were as follows. The forest plot showed that the combined effect of the six articles showed an RR of 0.47 and was statistically significant (p <0.001). Conclusion. Based on the results of this meta-analysis, L. reuteri DSM 17938 is recommended for infants with infantile colic. There were no significant side effects with the use of L. reuteri DSM 17938 on infantile colic.

scholarly journals The Efficacy and Safety of Traditional Chinese Medicine Tonifying-Shen (Kidney) Principle for Primary Osteoporosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-21
Author(s):  
Junquan Liang ◽  
Fengyi Wang ◽  
Jiajia Huang ◽  
Yunxiang Xu ◽  
Guizhen Chen
Keyword(s):  
Data Extraction ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Primary Osteoporosis ◽  
Efficacy And Safety ◽  
Data Synthesis ◽  
Assessment Development ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Superior Effect

Objective. This study aimed to appraise the efficacy and safety of the tonifying-Shen (kidney) principle (TS (TK) principle) for primary osteoporosis (POP). Methods. Randomized controlled clinical trials (RCTs) using the TS (TK) principle for POP were searched from eight electronic databases to search for relevant literature that was published from the initiation to September 2019. Two reviewers performed study selection, data extraction, data synthesis, and quality assessment independently. Review Manager 5.3 software was used to assess the risk of bias and conduct the data synthesis. We assessed the quality of evidence for outcomes by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results. Thirty-six studies with 3617 participants were included. Meta-analysis showed a consistently superior effect of the TS (TK) principle combined with conventional Western medicine (CWM) in terms of total effectiveness rates (RR = 1.28; 95% CI (1.23, 1.33); P < 0.00001 ), BMD of the lumbar spine (SMD = 0.71; 95% CI (0.47, 0.95); P < 0.00001 ) and proximal femur (SMD = 0.94; 95% CI (0.49, 1.38); P < 0.00001 ), TCM symptom integral (SMD = −1.23; 95% CI (−1.43, −1.02); P < 0.00001 ), and VAS scores (SMD = −3.88; 95% CI (−5.29, −2.46); P < 0.00001 ), when compared to using CWM alone and with significant differences. Besides, in respect of adverse effects, it showed no significant statistical difference between the experimental and control groups, RR = 0.99 and 95% CI (0.65, 1.51), P = 0.97 . Conclusion. Our meta-analysis provides promising evidence to suggest that using the TS (TK) principle combined with CWM for POP is more effective than using CWM alone. Also, both of them are safe and reliable for POP.

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