Histomorphological Features of Neoplastic and Non-Neoplastic Lymph Node Lesions in a Tertiary Care Hospital in South India

BACKGROUND Lymphadenopathy is a common clinical condition and biopsies are usually undertaken to determine the cause of nodal enlargement, which may be neoplastic or non-neoplastic. The neoplastic disorders are categorized into haematolymphoid malignancies and metastasis, while the causes of non-neoplastic lymphadenopathy are diverse. This study was undertaken to determine the histopathological spectrum in lymph node biopsies. METHODS This was a descriptive study of 357 cases of histologically diagnosed peripheral lymph node biopsies in the Department of Pathology, Govt. Medical College, Thiruvananthapuram, Kerala, S. India conducted from January 2019 to December 2019. Treated cases of malignancies were excluded. RESULTS The non-neoplastic lesions were more common accounting for 67.2 % (240 cases) which included 40.3 % (144 cases) of non-specific reactive lymphoid hyperplasia, 3.9 % (14 cases) of other specific lymphoid hyperplasia, 16.2 % (58 cases) of tuberculous lymphadenitis, 6.7 % (24 cases) of other granulomatous lesions. Neoplastic lesions accounted for 32.8 % (117 cases) and included 16.2 % (58 cases) of non-Hodgkin’s lymphoma, 3.9 % (14 cases) of Hodgkin’s lymphoma and 12.6 % (45 cases) of metastatic lesions. CONCLUSIONS Lymph node biopsy plays an important role in establishing the cause of lymphadenopathy. Among the biopsied nodes, reactive follicular hyperplasia was the most common (40.3 %) followed by Non-Hodgkin’s lymphoma and tuberculous lymphadenitis (16.2 % each) and metastasis (12.6 %). KEYWORDS Lymphadenopathy, Lymph Node, Metastasis, Non-Hodgkin’s Lymphoma, Reactive Lymphoid Hyperplasia, Tuberculosis

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Translocation (14;18)-positive cells are present in the circulation of the majority of patients with localized (stage I and II) follicular non- Hodgkin's lymphoma

Blood ◽

10.1182/blood.v82.8.2510.2510 ◽

1993 ◽

Vol 82 (8) ◽

pp. 2510-2516 ◽

Cited By ~ 40

Author(s):

AC Lambrechts ◽

PE Hupkes ◽

LC Dorssers ◽

MB van't Veer

Keyword(s):

Bone Marrow ◽

Lymph Node ◽

Peripheral Blood ◽

Hodgkin’S Lymphoma ◽

Lymph Node Biopsy ◽

Stage I ◽

Hodgkin's Lymphoma ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma ◽

Sensitive Polymerase Chain Reaction

Abstract Stage I and II follicular non-Hodgkin's lymphoma (NHL) is clinically defined as a localized disease. To study the possibility that this disease is in fact disseminated, we used the sensitive polymerase chain reaction (PCR) method using translocation (14;18) as marker. Samples from 21 patients who were clinically diagnosed with stage I or II follicular NHL were analyzed for the presence of t(14;18)-positive cells using PCR. We analyzed (1) the diagnostic lymph node biopsy and (2) the peripheral blood or bone marrow samples from these patients. Translocation (14;18) cells were detected in the diagnostic lymph node biopsies of 12 patients. In 9 of these patients, t(14;18)-positive cells were detected in peripheral blood and/or bone marrow samples at diagnosis and/or after therapy. Thus, in 75% of the follicular NHL patients carrying the t(14;18) as a marker for lymphoma cells, t(14;18)- positive cells were detected in peripheral blood and bone marrow at diagnosis and after therapy. Our results show that t(14;18)-positive cells can be detected in the circulation of patients with stage I and II follicular NHL, indicating that, although diagnosed as localized, the disease is disseminated.

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Concurrent Non-Small Cell Carcinoma and Non-Hodgkin’s Lymphoma Within a Same Lymph Node

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7003 ◽

2019 ◽

Author(s):

E. Henderson ◽

S. Jha ◽

S. Taj-Eldin ◽

V. Pathak

Keyword(s):

Lymph Node ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Hodgkin’S Lymphoma ◽

Small Cell ◽

Hodgkin's Lymphoma ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma

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Primary laryngeal lymphoma in China: a retrospective study of the last 25 years

The Journal of Laryngology & Otology ◽

10.1017/s0022215119001622 ◽

2019 ◽

Vol 133 (09) ◽

pp. 792-795

Author(s):

P Zhao ◽

Y Zhou ◽

J Li

Keyword(s):

Lymph Node ◽

T Cell ◽

Hodgkin’S Lymphoma ◽

Chinese Language ◽

Lymph Node Involvement ◽

Hodgkin's Lymphoma ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma ◽

Node Involvement ◽

Language Literature

AbstractObjectiveTo retrospectively study the primary laryngeal lymphoma cases in China reported in Chinese-language literature.MethodChinese-language literature was searched for papers on primary laryngeal lymphoma published in the last 25 years.ResultsThe selected papers comprised a total of 115 cases. The male-to-female ratio was 3.4:1. Non-Hodgkin's lymphoma was the exclusive pathological type. The estimated 3-year, 5-year and 10-year survival rates were 70.9 ± 6.4 per cent, 63.4 ± 7.6 per cent and 56.4 ± 9.5 per cent respectively, as determined by Kaplan–Meier analysis. B-cell non-Hodgkin's lymphoma patients had a better prognosis than T-cell non-Hodgkin's lymphoma patients (p = 0.032). Patients with lymph node involvement at diagnosis had a poorer prognosis (p < 0.01).ConclusionPrimary laryngeal lymphoma is a rare disease with no specific clinical features. More than one biopsy might be needed to obtain the correct diagnosis. Proper treatment could lead to promising outcomes. The T-cell subtype and lymph node involvement at diagnosis might indicate worse prognosis.

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Primary non-Hodgkin's lymphoma arising in an intramammary lymph node

Leukemia & Lymphoma ◽

10.1080/10428190400015717 ◽

2005 ◽

Vol 46 (3) ◽

pp. 451-455 ◽

Cited By ~ 7

Author(s):

Ioannis Venizelos ◽

Zoi Tatsiou ◽

Sofia Vakalopoulou ◽

Eudokia Mandala ◽

Vasiliki Garipidou

Keyword(s):

Lymph Node ◽

Hodgkin’S Lymphoma ◽

Hodgkin's Lymphoma ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma ◽

Intramammary Lymph Node

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Primary, Bilateral and Diffuse Renal Non-Hodgkin’s Lymphoma in a Young Woman Suffering from Turner Syndrome

Journal of Personalized Medicine ◽

10.3390/jpm11070644 ◽

2021 ◽

Vol 11 (7) ◽

pp. 644

Author(s):

Bernardo Rossini ◽

Tetiana Skrypets ◽

Carla Minoia ◽

Angela Maria Quinto ◽

Gian Maria Zaccaria ◽

...

Keyword(s):

Lymph Node ◽

Rare Disease ◽

Turner Syndrome ◽

Hodgkin’S Lymphoma ◽

Hodgkin's Lymphoma ◽

Rare Form ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma ◽

Extranodal Lymphomas ◽

Personalized Approach

Primary renal lymphoma (PRL) is a rare form of non-Hodgkin’s lymphoma (NHL) restricted to and primarily involving one or both kidneys, with no lymph node extension. It accounts for <1% of extranodal lymphomas, and descriptions in the literature are limited. Here, we describe an unprecedented case of bilateral PRL in a 44-year-old woman with Turner syndrome and discuss both diagnostic and therapeutic issues in the light of the available literature in the field. A personalized approach to this rare disease is necessary.

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