OPRM1 and ABCB1 Polymorphisms and Their Effect on Postoperative Pain Relief With Piritramide

Genetic factors may contribute to the differential response to opioids. The aim of this study was to evaluate the association between polymorphisms of µ1-opioid receptor gene OPRM1 (rs1799971), and P-glycoprotein transporter gene ABCB1 (rs1045642, rs2032582), and piritramide efficacy under postoperative patient-controlled analgesia (PCA). In 51 patients, OPRM1 variant was associated with decreased efficacy in early postoperative period evidenced by sum of pain intensity difference in the 0-6 h postoperative period (SPID0-6), (F=3.27, p=0.029). Mean (SD) SPID0-6 was observed in the 118AA genotype 22.9 (6.1) mm, which was significantly higher from the 118GG genotype 10.0 (4.4) mm, p=0.006. The lowest cumulative dose was recorded in 118AA genotype 19.1 (9.8) mg, which was significantly less than in the 118GG genotype group 36.6 (6.1) mg, p=0.017. Opioid–induced adverse effects were observed in 11, 30, and 100 % of patients in 118AA, 118AG, and 118GG genotype groups, respectively (p<0.05). Piritramide efficacy and safety was not significantly affected by ABCB1 (rs1045642, rs2032582) polymorphisms. Variant OPRM1 118G allele is associated with decreased acute postoperative pain relief after piritramide. Decreased efficacy leads to higher drug consumption under PCA settings, which however, does not fully compensate insufficient pain relief, but increases incidence of adverse effects.

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A Study on Haemodynamic and Adverse Effects of Intramuscular Parecoxib in Adults for Postoperative Pain Relief

Indian Journal of Anaesthesia and Analgesia ◽

10.21088/ijaa.2349.8471.4417.11 ◽

2017 ◽

Vol 4 (4 (Part-1)) ◽

pp. 979-983

Author(s):

Geetanjali S. Masamaddi ◽

◽

Ram Prasad Harsha ◽

Kiran S.K. ◽

◽

...

Keyword(s):

Postoperative Pain ◽

Pain Relief ◽

Adverse Effects ◽

Postoperative Pain Relief

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Multicenter study of the effectiveness of postoperative pain relief in Ukraine using paracetаmol in surgical hospitals – “ROZUM”

Pain medicine ◽

10.31636/pmjua.v6i3.1 ◽

2021 ◽

Vol 6 (3) ◽

pp. 4-14

Author(s):

Dmytro Dmitriev ◽

Ya Feleshtynskyi ◽

S Vasyliuk ◽

V Shaprynskyi ◽

Yu Derkach ◽

...

Keyword(s):

Postoperative Pain ◽

Pain Relief ◽

Multicenter Study ◽

Postoperative Period ◽

Pain Syndrome ◽

Multimodal Analgesia ◽

Surgical Patients ◽

Postoperative Pain Relief

This article is devoted to the effectiveness of postoperative pain relief in surgical hospitals in Ukraine. Multicenter study of the effectiveness of postoperative pain relief in Ukraine using paracetаmol in surgical hospitals – ROZUM is descibed. The effectiveness of multimodal analgesia and other analgesia in the postoperative period has been determined. Predictors of inadequate pain relief in surgical patients were identified, and the risks of pain syndrome development in a surgical hospital were assessed. The use of paracetamol in the schemes of multim

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Efficiency and safety of pharmacotherapy for postoperative pain in cardiac surgery

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2021-2683 ◽

2021 ◽

Vol 20 (3) ◽

pp. 2683

Author(s):

D. A. Sychev ◽

T. E. Morozova ◽

D. A. Shatskiy ◽

E. V. Shikh

Keyword(s):

Cardiac Surgery ◽

Postoperative Pain ◽

Pain Relief ◽

Postoperative Period ◽

Multimodal Analgesia ◽

Early Postoperative Period ◽

Current Review ◽

Negative Effect ◽

Safe Technique

Intraoperative injury with the formation of a sternotomy wound is inevitably accompanied by postoperative pain, which has a negative effect on the postoperative period and prognosis of patients. Today, moderate and severe pain affects at least half of patients in the early postoperative period after cardiac surgery. Inadequate pain relief in the early postoperative period can lead to chronic pain, which significantly reduces the quality of life of patients. The concept of multimodal analgesia with different painkillers is a priority, effective and safe technique both after cardiac surgery and in other areas of surgery. The current review article is devoted to the analysis of efficacy and safety of various drug groups for postoperative pain relief in cardiac surgery.

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THE STRUCTURE OF ODONTOGENIC INFLAMMATORY DISEASES AT THE OUTPATIENT SURGICAL DENTISTRY

The actual problems in dentistry ◽

10.18481/2077-7566-2018-14-2-78-85 ◽

2018 ◽

Vol 14 (2) ◽

pp. 78-85 ◽

Cited By ~ 2

Author(s):

Ирина Костина ◽

Irina Kostina ◽

Александр Чернавский ◽

Aleksandr Chernavskiy ◽

Михаил Огнев ◽

...

Keyword(s):

Postoperative Pain ◽

Pain Relief ◽

Postoperative Period ◽

Analgesic Effect ◽

Inflammatory Diseases ◽

Surgical Techniques ◽

Pain Syndrome ◽

Symptomatic Treatment ◽

Postoperative Pain Relief ◽

Dental Procedures

Importance. NSAIDs take one of the leading places in drug therapy for postoperative pain relief. They are among the most common medicines used in clinical practice of a dentist. The article presents a comparative clinical evaluation of NSAID analgesic effect in postoperative period of dental surgical techniques. Objective. is to compare the etoricoxib analgesic effect of oral administration in a dosage of 90 mg and nimesulide in dosage of 100 mg in the postoperative period of dental surgical techniques. Methods. Randomized prospective study included 46 patients aged from 20 to 59 years. Two groups of 23 patients (10 men, 13 women in each group) were formed. They were prescribed medications for the pain relief after surgery. Etoricoxib in tablets of 90 mg 1 time a day was prescribed to the patients of the first group. In the second group nimesulide tablets of 100 mg were taken 2 times a day. The patients had taken the pills for three days. Results. Reduction of pain syndrome took place in the first and third day after tooth extraction. The comparison is performed by using visual analogue scale (VAS). Conclusions. Using of etoricoxib as symptomatic treatment of pain syndrome relief after application of surgical dental procedures provides fast, pronounced and long lasting analgesic effect. The drug is effective for preemptive analgesia and also for prevention of inflammatory complications in ambulatory surgical dentistry. It has a favorable safety profile that allows using it extensively in postoperative pain relief.

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