Cytokine Patterns in Iranian Patients with Asthma

2021 ◽  
Author(s):  
Soheila Alyasin ◽  
Zahra Kanannejad ◽  
Hossein Esmaeilzadeh ◽  
Hesamedin Nabavizadeh ◽  
Reza Amin
Keyword(s):  
Airway Inflammation ◽  
Complex Network ◽  
Healthy Subjects ◽  
Respiratory Diseases ◽  
Asthma Severity ◽  
Iranian Patients ◽  
Chronic Airway

Asthma is one of the most common respiratory diseases caused by chronic airway inflammation. A complex network of cytokines could affect asthma development. IL-4, IL-13, IL-17, and IL-33 have been identified as cytokines associated with asthma severity and these cytokines can be considered as candidate biomarkers for predicting the asthma severity while the IL-10 is lower in asthmatics compared with healthy subjects. There are many controversies about the IL-22, IL-25, and TGF-β levels between the Iranian publications. No significant differences have been observed between the healthy subjects and the asthmatic cases regarding the IL-6 and IL-8.

Effects of Repeated Stress on Distal Airway Inflammation, Remodeling and Mechanics in an Animal Model of Chronic Airway Inflammation

2012 ◽  
Vol 19 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Edna A. Leick ◽  
Fabiana G. Reis ◽  
Flávia Alves Honorio-Neves ◽  
Rafael Almeida-Reis ◽  
Carla M. Prado ◽  
...  
Keyword(s):  
Animal Model ◽  
Airway Inflammation ◽  
Repeated Stress ◽  
Distal Airway ◽  
Chronic Airway

scholarly journals The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway

2020 ◽  
Author(s):  
Yingjie Zhu ◽  
Jingjing Luo ◽  
You Xu ◽  
Shucheng Hua ◽  
Dan Li ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Active Compound ◽  
Protective Role ◽  
Asthma Model ◽  
Common Illnesses ◽  
Murine Asthma Model ◽  
Chronic Airway

Asthma is one of the most common illnesses associated with chronic airway inflammation; however, there are currently no effective therapies apart from glucocorticoids. Zingerone (ZIN), an active compound isolated from...

scholarly journals Role of Neuro‐immune Interactions in a Cigarette Smoke‐induced Chronic Airway Inflammation Mouse Model

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Kata Csekő ◽  
István Szitter ◽  
Zsófia Hajna ◽  
Krisztián Elekes ◽  
Ágnes Kemény ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Cigarette Smoke ◽  
Chronic Airway

scholarly journals IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation

2019 ◽  
Vol 144 (6) ◽  
pp. 1624-1637.e10 ◽  
Author(s):  
Jeanne Allinne ◽  
George Scott ◽  
Wei Keat Lim ◽  
Dylan Birchard ◽  
Jonas S. Erjefält ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Chronic Airway

Correlation Of Body Mass Index (BMI) With Asthma Severity And Airway Inflammation

2010 ◽  
Author(s):  
Sandhya Khurana ◽  
Michael J. Larj ◽  
Laurie B. Lerner ◽  
Tania Aung ◽  
Susan M. Smith ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Airway Inflammation ◽  
Body Mass ◽  
Asthma Severity

scholarly journals Angiogenesis in Mice with Chronic Airway Inflammation

1998 ◽  
Vol 153 (4) ◽  
pp. 1099-1112 ◽  
Author(s):  
Gavin Thurston ◽  
Thomas J. Murphy ◽  
Peter Baluk ◽  
J. Russell Lindsey ◽  
Donald M. McDonald
Keyword(s):  
Airway Inflammation ◽  
Chronic Airway

Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes

2007 ◽  
Vol 293 (3) ◽  
pp. L730-L739 ◽  
Author(s):  
Jill R. Johnson ◽  
Filip K. Swirski ◽  
Beata U. Gajewska ◽  
Ryan E. Wiley ◽  
Ramzi Fattouh ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Inflammatory Responses ◽  
Airway Remodeling ◽  
Bronchial Hyperresponsiveness ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Th Cell ◽  
And Function ◽  
Deficient Mice ◽  
Chronic Airway

Asthma is a chronic airway inflammatory disease that encompasses three cardinal processes: T helper (Th) cell type 2 (Th2)-polarized inflammation, bronchial hyperreactivity, and airway wall remodeling. However, the link between the immune-inflammatory phenotype and the structural-functional phenotype remains to be fully defined. The objective of these studies was to evaluate the relationship between the immunologic nature of chronic airway inflammation and the development of abnormal airway structure and function in a mouse model of chronic asthma. Using IL-4-competent and IL-4-deficient mice, we created divergent immune-inflammatory responses to chronic aeroallergen challenge. Immune-inflammatory, structural, and physiological parameters of chronic allergic airway disease were evaluated in both strains of mice. Although both strains developed airway inflammation, the profiles of the immune-inflammatory responses were markedly different: IL-4-competent mice elicited a Th2-polarized response and IL-4-deficient mice developed a Th1-polarized response. Importantly, this chronic Th1-polarized immune response was not associated with airway remodeling or bronchial hyperresponsiveness. Transient reconstitution of IL-4 in IL-4-deficient mice via an airway gene transfer approach led to partial Th2 repolarization and increased bronchial hyperresponsiveness, along with full reconstitution of airway remodeling. These data show that distinct structural-functional phenotypes associated with chronic airway inflammation are strictly dependent on the nature of the immune-inflammatory response.

Identification of HLA-A/B/DRB1 alleles in Iranian patients with Fanconi anemia

2020 ◽  
Vol 28 (3) ◽  
pp. 221-226
Author(s):  
Arezou Sayad ◽  
Mohammadreza Ostadali Dehaghi ◽  
Mohammad Taheri ◽  
Hamid Fallah ◽  
Shahram Arsang-Jang ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Fanconi Anemia ◽  
Genetic Divergence ◽  
Healthy Subjects ◽  
The Other ◽  
P Value ◽  
Healthy Individuals ◽  
Hla Alleles ◽  
Other Hand ◽  
Iranian Patients

Fanconi anemia includes a number of clinically and genetically diverse disorders all of them being associated with genomic instability. Some previous studies reported higher frequencies of certain HLA alleles in patients with Fanconi anemia. In the current study, we genotyped HLA-A/B/DRB1 alleles in 40 Iranian patients with Fanconi anemia. We also genotyped these alleles in the same number of Iranian sex-matched healthy individuals. The frequency of DRB1*11 was significantly higher in patients compared with controls (OR (95% CI) = 2.143 [1.05, 4.46], P value = 0.036). On the other hand, the frequencies of DRB1*13 and B*13 were lower in patients compared with controls (OR (95% CI) = 0.134 [0.02, 0.55], P value = 0.003 and OR (95% CI) = 0.13 [0.01, 0.89], P value = 0.035, respectively). Assessment of genetic divergence using Fstat test showed complete divergence in HLA-A, -B, -DRB1 alleles and haplotypes between patients and controls. The current study provides evidences for different distribution of HLA alleles between patients with Fanconi anemia and healthy subjects.

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