Identification of HLA-A/B/DRB1 alleles in Iranian patients with Fanconi anemia

2020 ◽  
Vol 28 (3) ◽  
pp. 221-226
Author(s):  
Arezou Sayad ◽  
Mohammadreza Ostadali Dehaghi ◽  
Mohammad Taheri ◽  
Hamid Fallah ◽  
Shahram Arsang-Jang ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Fanconi Anemia ◽  
Genetic Divergence ◽  
Healthy Subjects ◽  
The Other ◽  
P Value ◽  
Healthy Individuals ◽  
Hla Alleles ◽  
Other Hand ◽  
Iranian Patients

Fanconi anemia includes a number of clinically and genetically diverse disorders all of them being associated with genomic instability. Some previous studies reported higher frequencies of certain HLA alleles in patients with Fanconi anemia. In the current study, we genotyped HLA-A/B/DRB1 alleles in 40 Iranian patients with Fanconi anemia. We also genotyped these alleles in the same number of Iranian sex-matched healthy individuals. The frequency of DRB1*11 was significantly higher in patients compared with controls (OR (95% CI) = 2.143 [1.05, 4.46], P value = 0.036). On the other hand, the frequencies of DRB1*13 and B*13 were lower in patients compared with controls (OR (95% CI) = 0.134 [0.02, 0.55], P value = 0.003 and OR (95% CI) = 0.13 [0.01, 0.89], P value = 0.035, respectively). Assessment of genetic divergence using Fstat test showed complete divergence in HLA-A, -B, -DRB1 alleles and haplotypes between patients and controls. The current study provides evidences for different distribution of HLA alleles between patients with Fanconi anemia and healthy subjects.

Abstract 5825: Association between Patterns of FDG Uptake and Arterial Wall Calcification on PET/CT and Atherogenic Risk Factors in Healthy Subjects

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Hiroya Narumi ◽  
Katsuya Yoshida ◽  
Nobusada Funabashi ◽  
Naotake Hashimoto ◽  
Isao Umehara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vascular Calcification ◽  
Healthy Subjects ◽  
Arterial Wall ◽  
Calcium Score ◽  
The Other ◽  
Fdg Uptake ◽  
Other Hand ◽  
Pet Ct ◽  
Fdg Pet Ct

Background: Augmented metabolic activity of macrophages leads to enough F-18 Fluorodeoxyglucose (FDG) uptake to allow visualization by positron emission tomography (PET). A large body of data, based on computed tomography (CT), has also accumulated concerning the relevance of vascular calcification to the atherosclerotic process. FDG PET/CT can localize both inflammatory changes and vascular calcification. The purpose of this study was to investigate risk factors contributing to these changes in the aorta in healthy subjects. Materials and Methods: A total of 66 consecutive healthy subjects (44 men, 22 women; age range, 30–82 years, mean age, 55.8 years) participating in a health check protocol including FDG PET/CT were evaluated retrospectively. We placed regions of interest on the arterial wall to measure FDG uptake by PET images. To assess arterial calcification, the calcium score of the aorta was measured on CT images. Results: FDG uptake was observed most commonly in proximal, followed by descending, thoracic, and abdominal segments. On the other hand, the most common site of vascular calcification was the descending thoracic aorta, followed by abdominal and, proximal segment. Whole aortic calcification (total calcium score of the whole aorta) was significantly correlated with age (r= 0.353, P= 0.004). On the other hand, FDG uptake (total SUV max of the whole aorta) was significantly correlated with systolic blood pressure (SBP) (r= 0.303, P= 0.013), triglyceride (TG) (r= 0.281, P= 0.022), fasting plasma glucose (FPG) (r= 0.317, P= 0.010), HbA1c (r= 0.433, P< 0.001), visceral abdominal fat area (r= 0.319, P= 0.005), and was negatively correlated with high density lipoprotein (HDL) (r= −0.317, P= 0.010), and adiponectin (r= −0.273, P= 0.029). Conclusions: Aortic calcification was significantly correlated with age. On the other hand, FDG uptake was significantly correlated with the components of metabolic syndrome such as SBP, TG, FPG, HbA1c, visceral adipose fat area and negatively correlated with HDL and adiponectin, but not with age. Our results may suggest that the components of metabolic syndrome and aging affect the progression of atherosclerosis differently.

scholarly journals Prediction of Foetal Well-being with Non-stress Test

2016 ◽  
Vol 33 (2) ◽  
pp. 65-69
Author(s):  
Jahanara Rahman ◽  
Hosne Ara Begum
Keyword(s):  
Caesarean Section ◽  
Vaginal Delivery ◽  
Gestational Age ◽  
Apgar Score ◽  
Stress Test ◽  
The Other ◽  
P Value ◽  
Mild Depression ◽  
Other Hand ◽  
Significant Difference

Introduction: Non-stress test (NST) is the most common antenatal test performed to assess the foetus at risk of intrauterine hypoxia. On the other hand non-reactivity detected by NST increases the interferences of pregnancy by Caesarean section.Methodology: A cross sectional descriptive study was carried out in the department of Obstetrics and Gynaecology at Dhaka National Medical College between July2007 and June 2008.Objectives: The objectives of the study were (1) To observe the mode of delivery in cases of non-reactive non stress test (NST) and (2) To evaluate perinatal outcome of non-reactive NST.Results: A total 137 high risk pregnant women were included in the study. Age of the women ranges from 16 to 32 years. The mean age of the women was 23.74 ± 3.71 year. Among them 44.53% were primaegravida and 55.47% were multigravida. Gestational age was between 35 and 42 weeks and mean gestational age was 38.34±1.42 weeks. Regarding foetal reactivity 61.3% (n=84) were reactive and 38.7 % (n=53) were non-reactive. Among the babies of non reactive NST 98.11% and 1.89% were delivered by caesarean section and vaginal delivery respectively. Whereas, 48.81% and 51.19% babies of reactive NST were delivered by caesarean section and vaginal delivery respectively. The percentage of caesarean section was much higher in non-reactive NST cases in comparison to that of reactive NST which was statistically highly significant (p value 0.0000). One minute after birth APGAR scoring revealed that 56.6% and 43.4% newborn of non-reactive NST had no depression( APGAR score 7-10) and mild depression ( APGAR score 4-6) respectively. On the other hand 65.47% and 34.5% newborn of reactive NST had no depression and mild depression respectively at one minute after birth. Therefore, small difference was noticed in the neonatal status between the reactive and non-reactive NST which had no statistical significance (p value 0.507). Evaluation of the neonates with APGAR scoring done 5 minutes after birth revealed mild depression (APGAR score 4-6) in 24.53% and 20.24% of non-reactive and reactive NST cases respectively and no depression (APGAR score 7- 10) was found in 75.47% and 70.76% in reactive and nonreactive NST respectively. So, 5 minutes after birth the neonatal status among reactive and non-reactive NST made no significant difference (p value 0.9266).Conclusion: Neonatal evaluation revealed that all foetuses were not compromised as detected by NST. Relying on NST the rate of Caesarean section has been increased. Reassessment of the foetal conditions was needed with the help of other techniques. Therefore NST alone is insufficiently predictive of neonatal outcome.J Bangladesh Coll Phys Surg 2015; 33(2): 65-69

scholarly journals Hair Mercury Levels in Periodontal Patients in Comparison with Healthy Individuals

2014 ◽  
Vol 5 (3) ◽  
pp. 166-169 ◽  
Author(s):  
Soraya Khafri ◽  
Hamidreza Hasanjani Roushan ◽  
Hadi Parsian ◽  
Ramin Alijannia ◽  
Abbas Mosapour
Keyword(s):  
Chronic Periodontitis ◽  
Healthy Subjects ◽  
Periodontal Diseases ◽  
Mercury Level ◽  
Control Group ◽  
P Value ◽  
Healthy Individuals ◽  
Hair Mercury ◽  
Hair Samples ◽  
The Difference

ABSTRACT Introduction The clinical manifestation of periodontal diseases (such as gingivitis and chronic periodontitis) results from a complex interplay between the etiologic agents such as bacteria that present in the dental plaque, genetic factors, systemic diseases, smoking and exposure of some heavy metals, such as mercury. In this study, we aimed to evaluate hair mercury levels in healthy subjects in comparison with periodontal patients. Materials and methods One hundred twenty subjects were enrolled in this study. The included persons were divided into 3 groups: healthy subjects (n = 40), gingivitis (n = 40) and chronic periodontitis patients (n = 40). Hair samples were collected from occipital area of head. Total mercury levels were determined by atomic absorption spectrophotometry. Results The difference between mercury levels in three groups were statistically significant (p-value < 0.001). Mercury level in periodontitis patients was greater than the gingivitis group (p-value < 0.001). In addition the differences between mercury levels in periodontitis patients vs healthy individuals was significant (p-value = 0.048). The gingivitis patients had lower levels of mercury than the control group, but the difference was not significant (p-value = 0.170). Conclusion The results showed that the levels of mercury are to some extent differed in periodontal diseases in comparison with the healthy individuals. A study with larger sample size is needed for clarification of this issue. How to cite this article Roushan HH, Parsian H, Alijannia R, Mosapour A, Khafri S. Hair Mercury Levels in Periodontal Patients in Comparison with Healthy Individuals. World J Dent 2014;5(3):166-169.

scholarly journals Fractal properties in sensorimotor variability unveil internal adaptations of the organism before symptomatic functional decline

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kjerstin Torre ◽  
Grégoire Vergotte ◽  
Éric Viel ◽  
Stéphane Perrey ◽  
Arnaud Dupeyron
Keyword(s):  
Early Detection ◽  
Functional Ability ◽  
Healthy Subjects ◽  
Functional Decline ◽  
The Other ◽  
Limit Case ◽  
Other Hand ◽  
Fractal Properties ◽  
The One

Abstract If health can be defined as adaptability, then measures of adaptability are crucial. Convergent findings across clinical areas established the notion that fractal properties in bio-behavioural variability characterize the healthy condition of the organism, and its adaptive capacities in general. However, ambiguities remain as to the significance of fractal properties: the literature mainly discriminated between healthy vs. pathological states, thereby loosing perspective on the progression in between, and overlooking the distinction between adaptability and effective adaptations of the organism. Here, we design an experimental tapping paradigm involving gradual feedback deprivation in groups of healthy subjects and one deafferented man as a pathological-limit case. We show that distinct types of fractal properties in sensorimotor behaviour characterize, on the one hand impaired functional ability, and on the other hand internal adaptations for maintaining performance despite the imposed constraints. Findings may prove promising for early detection of internal adaptations preceding symptomatic functional decline.

scholarly journals Relationship between daily rumination time, physical activity, estrus and metabolic changes in dairy cows

2016 ◽  
Vol 73 (2) ◽  
pp. 224
Author(s):  
Razvan Nicolae Malancus ◽  
Cristina Maria Malancus
Keyword(s):  
Physical Activity ◽  
Dairy Cows ◽  
Metabolic Disorders ◽  
Metabolic Changes ◽  
The Other ◽  
P Value ◽  
Statistical Assessment ◽  
Other Hand ◽  
Two Factors ◽  
The One

The present study attempted to ascertain whether there is any connection between reduced daily rumination time and increased physical activity of the animals, on the one hand, and the presence of estrus or metabolic disorders in dairy cows, on the other hand. It has been observed that of the total of 168 cows, 55 (32.73%) showed decreased daily rumination time, 57 cows (33.92%) had specific manifestations for estrous period, while 25 cows (14.88%) showed both decreased daily rumination time and the presence of estrus. Statistical assessment of the data demonstrated a highly significant correlation between these two factors, with a p-value <0.05 (p = 0.0369). Regarding the correlation between increased physical activity, found in 40 cows (23.80%) and the presence of estrus, observed in 57 cows (33.92%) this one is extremely statistically significant with a p-value <0.001 (p = 0.0005), the combination of increased physical activity and estrus being detected in a total of 23 cows (13.69%). Thus, of 168 dairy cows taken into the study, 37 (22.02%) showed an association between decreased daily rumination time and increased physical activity, resulting in a extremely statistically significant correlation between the combination of the two events and the presence of estrus in cows, with a p-value <0.001 (p = 0.0003). Metabolic disorders were found in a total of 12 dairy cows (7.14 %), the association between decreased daily rumination time and increased physical activity being not statistically correlated with the development of metabolic disorders, p = 0.4676 . It remains to be observed if a correlation between the association of decreased daily rumination time and increased physical activity with the presence of metabolic disorders exists.

THE INFLUENCE OF MUDHARABAH AND MUSYARAKAH INCOME TOWARDS BRI SYARIAH PROFITABILITY

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Zulkarnain Karundeng
Keyword(s):  
Quantitative Method ◽  
Hypothesis Test ◽  
Research Data ◽  
The Other ◽  
P Value ◽  
Financial Report ◽  
Independent Variables ◽  
Other Hand

AbstractThis study aims to discover the influents of Mudharabah and Musyarakah income towards BRI Syariah profitability. The researcher applied the quantitative method using two variables. They are mudharabah and musyarakah (x) and profitability (y). The research samples are quarterly financial report published by BRI Syariah during 2010-2015 periods. Research data are initially exposed to a classical assumption test in order to check whether those data are compatible for hypothesis test. The classical assumption test includes normality, multicollinearity, autocorrelations and heteroscedasticity test. Based on the hypothesis test, the dependent variable which can be explained by the independent variables is 29,9 % while the rest 71,1 % are explained by other variables. The simultant test (F) shows that variable x is influenced by variable y. it is proven by a p-value that is smaller than the level of significant (0,027 < 0,05). On the other hand, musyarakah is not affected since the p-value is bigger than the level of significant (0,319 > 0.15).Keywords :Mudharabah, Musyarakah, Profitability

scholarly journals How Do Cytokines Trigger Genomic Instability?

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Ioannis L. Aivaliotis ◽  
Ioannis S. Pateras ◽  
Marilena Papaioannou ◽  
Christina Glytsou ◽  
Konstantinos Kontzoglou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Genomic Instability ◽  
The Other ◽  
Cancer Development ◽  
Tumor Initiation ◽  
Dual Effect ◽  
Other Hand ◽  
Shed Light ◽  
Comprehensive Study

Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer.

THE PHYSICOCHEMICAL PROPERTIES OF HUMAN HEMAGGLUTININS TO TUBERCULIN PURIFIED PROTEIN DERIVATIVE

1967 ◽  
Vol 45 (9) ◽  
pp. 1343-1352
Author(s):  
Raymond Turcotte ◽  
Samuel O. Freedman ◽  
Alec H. Sehon
Keyword(s):  
Pulmonary Tuberculosis ◽  
Physicochemical Properties ◽  
The Other ◽  
Healthy Individuals ◽  
Skin Reactions ◽  
Passive Hemagglutination ◽  
Active Pulmonary Tuberculosis ◽  
Purified Protein Derivative ◽  
Other Hand ◽  
Human Sera

Two distinct types of hemagglutinins to the tuberculin purified protein derivative (PPD) can be detected in human sera by the bisdiazotized benzidine (BDB) passive hemagglutination technique. The sera of patients with active pulmonary tuberculosis contained two types of hemagglutinins with properties of IgG- and IgM-immunoglobulins, the former being in excess. On the other hand, most of the hemagglutinins produced by healthy individuals with positive tuberculin skin reactions had physicochemical properties similar to those of IgM- and (or) IgA-globulins.

scholarly journals The popularity and acceptability of ultimate fighting championships among the aficionados and sports enthusiasts

10.17158/508 ◽  
2016 ◽  
Vol 20 (2) ◽  
Author(s):  
Renan P. Limjuco ◽  
Francis Kenneth D. Canono ◽  
John Gregory A. Manapol ◽  
Emma N. Ramos
Keyword(s):  
Significant Relationship ◽  
Reliable Data ◽  
The Other ◽  
P Value ◽  
Sport Event ◽  
Other Hand ◽  
Ultimate Fighting Championship ◽  
The Many ◽  
Survey Questionnaires

Ultimate Fighting Championship (UFC) has been aired for 20 years in some television networks worldwide. Among the many issues that this sport is facing is the violence that goes with it during the event. Despite this alarming scenario, aficionados and sport enthusiasts are still hooked in its television concepts and formats. This study explored the level of popularity and acceptability of UFC sport among youth and parents. It also assessed whether there exists a significant relationship between the mentioned variable. This study made use of the descriptive design, specifically correlation to establish reliable data with regard to its popularity and acceptability as a sport through the survey questionnaires (α = 0.739 for awareness and α = 0.873 for acceptability). Findings revealed significant relationship in terms of the level of frequency of watching UFC and acceptability (p-value &lt; .05). On the other hand, it showed that there is a significant relationship between popularity and acceptability (p-value &lt; .05). These would mean that the more exposed the youth and parent to this sport, the more that they have learned to accept UFC not only as an entertainment but also as a standard sport event.<div> </div><div> </div><div> </div><strong>Keywords:</strong>Ultimate Fighting Championships, aficionados, sports enthusiast, violence, Descriptive, Philippines<div> </div>

scholarly journals Experiential Outdoor Activities In Improving Students’ Vocabulary Achievement

2020 ◽  
Vol 4 (2) ◽  
pp. 101-116
Author(s):  
Musrafidin Simanullang
Keyword(s):  
Test Score ◽  
Alternative Hypothesis ◽  
The Other ◽  
P Value ◽  
Outdoor Activities ◽  
Other Hand ◽  
Post Test ◽  
The Mean ◽  
Academic Year ◽  
Vocabulary Achievement

This research is A Classroom Action Research held at SMP Negeri 4 Sipoholon in Academic Year 2018/2019. The problem of the research is; Does experiential outdoor activities significantly improve the students’ vocabulary achievement of the eight grade students at SMP Negeri 4 Sipoholon? And the objective is to find out whether experiential outdoor activities significantly improve the students’ vocabulary achievement. The subject of the research is 20 students of the eight grade students of SMP N. 4 Sipoholon in academic year 2018/2019. This research was only acted in one cycle in which, that in pre-test there was not student who got good and very good interpretation yet there are one who was fail and 8 students who were poor, in the minimum criterion used in the school is 70, so the researcher concluded that based on the students’ pre-test score they are fail. In fact based on the data analysis of the post-test that there are 11 students who got very good (80 – 100) and 9 students got good (66 – 79), and none of the students got fair (56-65), poor (40-55), and fail (39). It means all the students passed the minimum criterion applied in that school. On the other hand, it can be concluded that experiential out-activities significantly improves the students’ vocabulary mastery. Besides, by analyzing the data through t-test, it can be concluded that the mean of students’ post test score is higher than the mean of students’ pre-test score or 78.25 55.25. In addition, p-value under df (degree of freedom) is 19 or 1.729, it was found t-value has a significant different with t-table or 78.25 1.729. On the other hand, it can be said that the Ho (null hypothesis) is rejected and the Ha (alternative hypothesis) is accepted, in which there is a significant improvement of students’ vocabulary achievement taught by experiential outdoor activities. Keyword: Experiential Outdoor Activities, Students’ Vocabulary Achievement

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