scholarly journals The Relationship between Dietary Inflammatory Index, Pulmonary Functions and Asthma Control in Asthmatics

2020 ◽  
Author(s):  
Ümüş Özbey ◽  
Aslı Uçar ◽  
Nitin Shivappa ◽  
James R Hebert
Keyword(s):  
Asthma Control ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Dietary Inflammatory Index ◽  
Act Scores ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Inflammatory Index ◽  
Pulmonary Functions ◽  
The Relationship

This cross-sectional study evaluates the relationship of the dietary inflammatory index (DII), a novel tool developed to measure the inflammatory capacity of a diet, with pulmonary functions and asthma control test (ACT) scores in asthmatic individuals. The study included 120 patients who were diagnosed with asthma for at least one year.  The anthropometric measurements, one-day long nutrition uptake records, pulmonary function tests, and ACT scores of the respondents were recorded and compared according to categories of the DII which was calculated from 24- hour recalls. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and ACT scores decreased with increasing DII tertiles (p<0.05). The total energy, carbohydrate, fat, and saturated fat uptake of the participants increased in parallel to DII (p<0.05); while vitamin A, C, and E uptakes, on the other hand, decreased as DII increased (p=0.0001). In conclusion, an increase in the inflammatory potential of diet among asthmatics decreases pulmonary functions and asthma control.

scholarly journals Does the asthma control test reflect inflammation?

2019 ◽  
Vol 6 ◽  
Author(s):  
Margherita Neri
Keyword(s):  
Asthma Control ◽  
Pulmonary Function Tests ◽  
Provocation Test ◽  
Control Test ◽  
Asthma Control Test ◽  
Asthmatic Patients ◽  
Bronchial Provocation Test ◽  
Nitric Oxide Level ◽  
The Relationship ◽  
Bronchial Provocation

The present issue of Multidisciplinary Respiratory Medicine includes a paper by Bora et al. [1] investigating the relationship between the asthma control test (ACT) and airway inflammation. In a group of stable asthmatic patients admitted to a pulmonary outpatient clinic, the authors carried out the ACT, pulmonary function tests, methacholine bronchial provocation test (MBPT), fractional exhaled nitric oxide level (FeNO), and induced sputum test. [...]

scholarly journals EVALUATION OF INDUCED SPUTUM CYTOLOGY IN ASTHMATIC CHILDREN

2021 ◽  
Author(s):  
Debora Carla Chong-Silva ◽  
Adriana Nascimento ◽  
Roberta Cunha ◽  
Elessandra Bitencourt ◽  
Leticia Botelho ◽  
...  
Keyword(s):  
Asthma Control ◽  
Inhaled Corticosteroids ◽  
Pulmonary Function Tests ◽  
Sputum Cytology ◽  
Asthma Control Test ◽  
Sputum Induction ◽  
Hypertonic Saline Solution ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Children With Asthma

Objective: To evaluate the viability of sputum cytology in asthmatic children, recognizing inflammatory patterns and correlating them with clinical, epidemiological and functional variables of the disease. Methods: This was a cross-sectional and observational study of children with asthma who underwent sputum induction through increasing concentrations of nebulized hypertonic saline solution from 3% to 7%. The samples were processed according to the technique developed by Pizzichini et al. and the cytological pattern classified as pauci-granulocytic, neutrophilic, eosinophilic and mixed. Samples with cell viability> 50% were considered adequate. Asthma control was assessed using the asthma control test (ACT). Results: Seventy-nine children performed sputum induction. Thirty-three samples were excluded because they were not viable for analysis, resulting in 46 samples. The children’s average age was 9.4 (± 3) years. There was a predominance of eosinophilic (25/46, 54.3%), followed by mixed (13/46, 28.3%), pauci-granulocytic (7/46, 15.2%) and neutrophilic (1/46, 2.2%) pattern. Sixty-three percent of the children had severe asthma and 84.7% were treated with inhaled corticosteroids. The ACT showed that 25 (56.8%) patients had the disease under control. Forty-five children (97.8%) underwent pulmonary function tests (spirometry) and in 13 cases (28.9%) an obstructive ventilatory defect was found. Conclusions: The eosinophilic profile was predominant in the assessed asthmatic children. Non-eosinophilic phenotypes were found, but less frequently. There was no difference between the clinical variables and the sputum profile in this study group. Sputum induction in children with asthma is feasible and safe and can contribute to a specific and personalized approach to the disease.

scholarly journals Higher Pro-Inflammatory Dietary Score is Associated with Higher Hyperuricemia Risk: Results from the Case-Controlled Korean Genome and Epidemiology Study_Cardiovascular Disease Association Study

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1803 ◽  
Author(s):  
Hye Sun Kim ◽  
Minji Kwon ◽  
Hyun Yi Lee ◽  
Nitin Shivappa ◽  
James R. Hébert ◽  
...  
Keyword(s):  
Large Scale ◽  
Cross Sectional Study ◽  
Disease Association ◽  
Dietary Inflammatory Index ◽  
Sectional Study ◽  
Cross Sectional ◽  
Food Frequency ◽  
Inflammatory Index ◽  
The Relationship ◽  
Dietary Score

In previous studies, the elevated dietary inflammatory index (DII®) scores have been consistently associated with several chronic diseases. However, the relationship with hyperuricemia remains unknown. The aim of this study was to determine if the DII is associated with hyperuricemia risk. The study included 13,701 participants (men 5102; women 8599) in a large-scale cross-sectional study in South Korea. A validated semi-quantitative food frequency questionnaire (SQFFQ) was used to measure dietary intake, and blood samples were obtained to determine hyperuricemia. As the DII score increased, the hyperuricemia risk increased among women (OR 1.35, 95% CI 1.03–1.77, p trend = 0.02). However, no significant results were found for men. Women with lower BMI scores had higher risks of hyperuricemia with higher DII scores (OR 1.62, 95% CI 1.05–2.52, p trend = 0.03). As the DII increased, however, only women who consumed alcohol (“past or current drinkers”) had higher risks of hyperuricemia (OR 1.92, 1.22–3.02, p trend = 0.004). Among the DII components, intake of flavonoids showed a significant association with the hyperuricemia risk in women (OR 0.75, 0.59–0.96, p trend = 0.03). Our results suggest that higher intake of pro-inflammatory diet is significantly associated with higher risk of hyperuricemia among women. These results reinforce the importance of less pro-inflammatory habitual dietary patterns in lowering the risk of hyperuricemia and secondary afflictions such as cardiovascular diseases.

scholarly journals The Role of FENO in Comparison to Spirometry and ACT in Control of Children Asthma Symptoms

2019 ◽  
Author(s):  
Abbas Dabbaghzadeh ◽  
Marzieh Tavakol ◽  
Mohammad Gharagozlou
Keyword(s):  
Asthma Control ◽  
Medical Center ◽  
Lung Function Test ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Before And After ◽  
The Mean ◽  
Act Score

  Fractional exhaled nitric oxide (FeNO) is a noninvasive marker of inflammation, used for monitoring asthma. The aim of this study was to compare FeNO, asthma control test (ACT), and lung function test (spirometry) in children aged 8-15 years. This observational, cross-sectional study was performed on76 asthmatic children (age, 8-15 years), who were referred to the Department of Immunology and Allergy, Children's Medical Center, Tehran, Iran during 2012-2013. Patients were matched for sex and age. The recruited patients were selected via consecutive sampling. FeNO was measured with a portable electrochemical analyzer and forced spirometry was performed according to the American Thoracic Society (ATS) guidelines. The ACT questionnaire was used and completed for all the patients.  The mean FeNO was 28.5±29.1 ppb, and the mean ACT score was 19.8±3.6. FeNO was significantly correlated with forced expiratory volume (FEV1) (r, 0.232; p=0.049) or 25-75% maximum expiratory flow (MEF 25-75) (r, -0.304; p=0.009). FeNO showed no significant correlation with ACT score or FEV1/forced vital capacity (FVC) (p>0.05). Additionally, there was no significant correlation between FeNO and changes in FEV1 and MEF 25-75% before and after the administration of bronchodilators (p>0.05). To improve asthma control, childhood ACT, FeNO, and spirometric tests can be used as complementary tools in clinical practice to detect children with poorly controlled asthma.

scholarly journals Does asthma control as assessed by the asthma control test reflect airway inflammation?

2019 ◽  
Vol 6 ◽  
Author(s):  
Mine Bora ◽  
Aylin Ozgen Alpaydin ◽  
Arzu Yorgancioglu ◽  
Gizem Akkas ◽  
Aydın Isisag ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Asthma Control ◽  
Pulmonary Function Tests ◽  
Provocation Test ◽  
Induced Sputum ◽  
Control Test ◽  
Act Scores ◽  
Asthma Control Test ◽  
Asthmatic Patients

Background and aims: The treatment of asthmatic patients is particularly focused on the control of symptoms as well as functional and inflammatory parameters. In our study, we investigated the relationship between the asthma control test (ACT) which evaluates symptoms and airway inflammation and functional parameters. Materials and methods: Stable asthmatic patients admitted to our pulmonary outpatient clinic were enrolled in the study consecutively and underwent the ACT, pulmonary function tests and methacholine bronchial provocation test (MBPT). Additionally, fractional exhaled nitric oxide level (FeNO) and induced sputum cell distribution were assessed. All these parameters were re-evaluated at the third month after adjusting medications of the patients according to baseline ACT scores. Results: Of the 101 patients screened, we analyzed 83 who proceeded to the follow up visit. At the baseline visit, 8 were totally controlled, 36 partially controlled and 39 uncontrolled according to ACT. At the follow up visit, 10 were totally controlled, 39 partially controlled and 34 uncontrolled. Comparison of the two visits in terms of all parameters revealed significant reductions only in the percentages of patients with MBPT positivity (p = 0.029) and FeNO levels > 20 ppb (p = 0.025) at follow up. The percentages of patients with FeNO > 20 ppb, MBPT positivity, induced sputum eosinophilia or induced sputum neutrophilia did not show significant differences between totally controlled, partially controlled and uncontrolled groups at both baseline and follow up visits. Conclusion: Although the ACT scores did not show significant correlations with the airway inflammation parameters tested in this study, a marked reduction in the percentage of patients with MBPT positivity and FeNO > 20 ppb at follow up may suggest the importance of the control concept in the management of asthma.

Dietary inflammatory index significantly affects lipids profile among adults: An updated systematic review and meta-analysis

2020 ◽  
pp. 1-17
Author(s):  
Mahdi Vajdi ◽  
Mahdieh Abbasalizad Farhangi ◽  
Mahsa Mahmoudi-Nezhad
Keyword(s):  
Systematic Review ◽  
Serum Lipids ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Case Control ◽  
Lipoprotein Cholesterol ◽  
Dietary Inflammatory Index ◽  
Cross Sectional ◽  
Inflammatory Index ◽  
The Relationship

Abstract. Background: The available data on the relationship between dietary inflammatory index (DII®) and serum lipids are controversial. This systematic review and meta-analysis aimed to investigate the relationship between DII® and serum lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) in general populations. Methods: PubMed, Web of Science, SCOPUS, and Cochrane electronic databases were systematically searched from inception to December 2019. Case-control, cohort or cross-sectional studies that evaluated the relationship between DII® and serum lipids were included. The random-effects model was applied to evaluate the pooled weighted mean difference (WMD) and 95% confidence intervals (CI). Results: In total, twenty-four cross-sectional and one case-control studies with a total sample size of 129,759 were included in the meta-analysis. The pooled results showed that the highest category of DII® was associated with 5.16 mg/dl increase in TC (Pooled WMD: 5.16; 95% CI: 0.58–9.73, p = 0.02) and 3.99 mg/dl increase in LDL-C (Pooled WMD: 3.99; 95% CI: 1.16–6.81, p = 0.006). However, no significant association between DII® scores, HDL-C and TG was found. In subgroup analysis, the geographical region, gender, and dietary assessment methods were potent sources of heterogeneity. Conclusion: This study showed that a higher level of DII® was associated with higher levels of TC and LDL-C in apparently healthy populations. Since the included studies had observational designs, therefore, no conclusion of causality was possible. More studies with interventional designs are required to elucidate the causality of the observed association between DII® and the risk of abnormal lipid profile.

scholarly journals Pro-inflammatory diet, frailty and sarcopenia: a study with older people in outpatient care

2021 ◽  
Vol 10 (17) ◽  
pp. e103101724488
Author(s):  
Gabriela Benatti de Oliveira ◽  
Cintia Midori Yogi ◽  
Fernanda de Carvalho Vidigal ◽  
Daniela Braga Lima ◽  
Alice Helena de Souza Paulino ◽  
...  
Keyword(s):  
Older People ◽  
Outpatient Care ◽  
Frailty Syndrome ◽  
Multiple Logistic Regression ◽  
Dietary Inflammatory Index ◽  
Cross Sectional ◽  
Inflammatory Index ◽  
European Working ◽  
Probabilistic Study ◽  
The Relationship

Objectives: To analyze the relationship between the Dietary Inflammatory Index (DII), sarcopenia, and frailty syndrome in older people. Methods: A cross-sectional, non-probabilistic study was carried out with 135 older people, attended by a general outpatient clinic. The older people were classified in relation to sarcopenia according to the European Working Group on Sarcopenia in Older People. The frailty classification was made through self-referred questions. The calculation of the DII was made using the iOS application IF RATING®. Association analysis was performed using multiple logistic regression. Results: Of the 135 older people evaluated, 17.78% were classified as sarcopenic and 47.41% as frail. No association was observed between the most inflammatory DII and sarcopenia. Regarding frailty syndrome, older people with a more inflammatory DII were more likely to be frail (OR=3.64; 95%CI=1.24-10.70). Discussion: These results could stimulate actions to promote an anti-inflammatory diet, with a view to preventing frailty in older people.

scholarly journals Asthma Control in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia: A Cross-sectional Study

2020 ◽  
Vol 14 (2) ◽  
Author(s):  
Kuan YC ◽  
Tan CH ◽  
Hong CM ◽  
How SH
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Fixed Dose ◽  
Sectional Study ◽  
Act Scores ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Chest Clinic

Introduction: Various initiatives and medications have been introduced to achieve better control of bronchial asthma. However total control according to Global Initiative for Asthma (GINA) remains elusive even at tertiary referral hospitals. Our study is to determine the level of asthma control (according to GINA 2009), Asthma Control Test (ACT) scores and the types of medications used among patients with bronchial asthma in a large tertiary hospital. Methods: A cross-sectional study of all patients with bronchial asthma who attended the Chest Clinic at Hospital Tengku Ampuan Afzan (HTAA) from 2009 to 2011. Patient demographics, self-administered ACT scores, GINA-defined level of asthma control and medications were documented. Results: 208 patients were recruited. There were 23.2%, 46.3% and 30.5% of patients with controlled, partly controlled and uncontrolled asthma respectively. The median ACT scores was 19 [inter quartile range (IQR) 6]. The most frequently used preventer therapy was inhaled long-acting β-agonist/corticosteroids (LABA/ICS) fixed-dose combination (61.7%), and 9.6% were not on preventer therapy. 75% of patients with controlled asthma were on LABA/ICS compared to 58.5% of the partly controlled and uncontrolled groups (p=0.039). Conclusion: The majority of the asthmatic patients attending the Chest Clinic at HTAA did not have GINA-defined controlled asthma. Patients with higher ACT scores had better control of asthma. There were more patients with controlled asthma who were on LABA/ ICS combination.

scholarly journals The Association between Dietary Inflammatory Index with Sleep Quality and Obesity among Iranian Female Students: A Cross-sectional Study

2020 ◽  
Author(s):  
hadi bazyar ◽  
ahmad zarejavid ◽  
Hossein Bavi Behbahani ◽  
SHIVAPPA NITIN ◽  
JAMES HEBERT ◽  
...  
Keyword(s):  
College Students ◽  
Sleep Quality ◽  
Cross Sectional Study ◽  
Female Students ◽  
Dietary Inflammatory Index ◽  
Sectional Study ◽  
Anthropometric Indices ◽  
Cross Sectional ◽  
Inflammatory Index ◽  
The Relationship

Background: Overweight, obesity and lack of sleep quality as inflammatory states are the common problems among college students and the Association of Dietary Inflammatory Index (DII) with these problems among this population is unknown. We aimed to evaluate the relationship of the DII with obesity and sleep quality among Iranian female students. Methods: The present cross-sectional study was conducted in 249 female college students. The Dietary Inflammatory Index (DII) was calculated using a valid and reliable 147-item food frequency questionnaire (FFQ). To assess sleep quality, Pittsburgh Sleep Quality Index (PSQI) was used. Odds Ratio (OR) and 95% Confidence Intervals (CIs) were estimated for anthropometric indices and sleep quality according to DII score. Linear regression was used to estimate the relationship between DII score with sleep and anthropometric indices. Results: There was a significant association evident between DII and sleep quality(> 5 is considered as poor quality of sleep); i.e., the odds ratios between DII quartile 2 vs 1 (unadjusted model: OR= 0.33 (CI: 0.14-0.74), P for trend =0.002; model 1: the fully adjusted OR= 0.31(CI: 0.12-0.78), P for trend = 0.005; model 2:OR=0.30 (CI:0.12-0.78), P for trend = 0.005) to quartile 4(unadjusted model: OR= 1.13(CI: 0.45-2.80); model 1: OR= 1.11(CI: 0.44-2.79); model 2:OR=1.13(CI:0.44-2.87), P for trend = 0.005). Also, odds ratios increased significantly from quartile 2 to quartile 4 in all models for DII and sleep quality. According to the continuous score of DII, there was a significant positive association between DII and sleep quality in all 3 models: unadjusted, model 1, and model 2 (OR= 1.21 (CI: 1.05-1.40), OR= 1.21 (CI: 1.03-1.43), and OR= 1.22 (CI: 1.03-1.44), respectively. Conclusions: In this study, after removing the effect of confounding factors, participants in the highest quartile of DII score had significantly higher PSQI global score.

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