scholarly journals Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

2020 ◽  
pp. 57-64
Author(s):  
Fatemeh Sadat Najib ◽  
Tahereh Poordast ◽  
Mina Rezvan Nia ◽  
Mohammad Hossein Dabbaghmanesh
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Homeostasis ◽  
Maternal Age ◽  
Serum Insulin ◽  
Glycosylated Hemoglobin ◽  
Insulin Level ◽  
Selenium Supplementation ◽  
Serum Insulin Level ◽  
The Mean ◽  
Selenium Supplements

Background: There is limited evidence about the anti-diabetic effects of selenium supplementation in women with gestational diabetes mellitus (GDM). Objective: This study investigates the effects of selenium supplementation on glucose homeostasis in women with GDM. Materials and Methods: A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100μg selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention. Results: The mean maternal age of the patients who took selenium supplements was 29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ± 4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2- hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87, p = 0.34, p = 0.57, and p = 0.31, respectively). Conclusion: The results of this trial suggest that supplementation with 100μg of selenium does not modulate glucose homeostasis in women with GDM. Key words: Diabetes, Gestational, Selenium.

scholarly journals Association of Hypertension with Type 2 Diabetes Mellitus in Adult female

2018 ◽  
Vol 29 (1) ◽  
pp. 7-12
Author(s):  
Nahid Yeasmin ◽  
Sayeeda Mahmuda ◽  
Shamima Akther ◽  
Sharmin Nahar ◽  
Zakia Sultana ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Blood Glucose ◽  
Diastolic Blood Pressure ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Serum Insulin Level ◽  
Fasting Serum ◽  
Medical College

Background: Diabetes mellitus is one of the most widespread endocrine disorder in female and its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and end stage renal diseases. An association between hypertension and diabetes mellitus has been identified.Objectives: The study was carried out to observe the association of hypertension with diabetes mellitus in adult female subjects.Methods : This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of one hundred female subjects were selected with age ranging from30 to50 years. Among them 50 diabetic female subjects were included from out-patient department of Endocrinology, Dhaka Medical College Hospital, Dhaka as study group(B) and 50 apparently healthy female were taken as control group(A) for comparison. Fasting serum insulin level was measured by ELISA method in the Department of Laboratory of National Institute of ENT, Dhaka and fasting blood glucose was estimated by glucose oxidase method in Department of Dhaka Medical College in both groups. Systolic blood pressure and diastolic blood pressure of all participants were recorded by standard method. Data was analyzed by Unpaired Student’s- test and Pearson’s correlation co-efficient (r) test as applicable.Results: The value of fasting serum insulin level was significantly higher in diabetic subjects than those of non-diabetic subjects. Fasting blood glucose level was significantly higher diabetic patient in comparison to those of non-diabetic subjects. In diabetic subjects fasting serum insulin and fasting blood glucose levels were higher and showed positive correlation with systolic and diastolic blood pressure.Conclusion: Present study revealed that systolic and diastolic blood pressure has positive relationship with fasting serum insulin and fasting blood glucose levels.Bangladesh J Medicine Jan 2018; 29(1) : 7-12

'True' fasting serum insulin level, insulin resistance syndrome and coronary artery disease

1997 ◽  
Vol 8 (11) ◽  
pp. 683-688 ◽  
Author(s):  
Mostafa Chaour ◽  
Pierre Théroux ◽  
Brian M. Gilfix ◽  
Lucien Campeau ◽  
Jacques Lespérance ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Insulin ◽  
Insulin Level ◽  
Insulin Resistance Syndrome ◽  
Serum Insulin Level ◽  
Fasting Serum ◽  
Artery Disease

Studies on hypoglycaemic effects of polyherbal preparation in streptozotocin-induced diabetic male albino rats

2009 ◽  
Vol 28 (11) ◽  
pp. 679-687
Author(s):  
A. Ismail Khan ◽  
S. Yuvaraj ◽  
E. Suthagar ◽  
C. Parthasarathy ◽  
K. Balasubramanian
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Skeletal Muscles ◽  
Glucose Oxidation ◽  
Serum Insulin ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Vehicle Group ◽  
Albino Rats ◽  
Serum Insulin Level

Many traditional treatments have been recommended in the alternative system of medicine for diabetes mellitus. However, the mode of action of most of the herbals used has not been defined. It has been reported that sex hormones are important regulators of insulin-mediated events in skeletal muscles. In view of this, a novel herbal preparation containing antidiabetic and aphrodisiac plants was used in the present study. Adult male albino rats were divided into following groups after induction of diabetes. Rats were given an intraperitoneal (i.p.) injection of streptozotocin (STZ), at a dose of 65 mg/kg body weight after overnight fasting, to induce diabetic state with blood glucose levels >250 mg/dL. Group 1—Control rats treated with single i.p. injection of vehicle, Group 2—Rats treated with polyherbal preparation (PHP; 500 mg/kg body weight by oral intubation, morning and evening for 30 days), Group 3—STZ-diabetic rats treated orally with equal volumes of vehicle (water) alone and Group 4—STZ-diabetic rats treated with PHP after 10 days of diabetic induction. STZ-diabetes decreased the body weight, serum insulin level and glucose oxidation in liver and skeletal muscles but increased the fasting blood glucose level. After polyherbal treatment, body weight and glucose oxidation were completely restored to control level while serum insulin level was restored partially and the glucose tolerance was significantly improved. There was a significant decrease in total haemoglobin (Hb) level of diabetic rats when compared to control but polyherbal treatment significantly improved the same. However, the other parameters studied (red blood cell [RBC], white blood corpuscle [WBC], packed cell volume [PCV], mean corpuscular volume [MCV] and mean corpuscular haemoglobin [MCH]) were unaltered. In conclusion, the anti-diabetic properties of PHP appear to be mediated through pancreatic β-cell regeneration, resulting in maintenance of optimal blood glucose and its oxidation in liver and skeletal muscles.

Positive correlation of paraoxonase 1 (PON1) activity with serum insulin level and HOMA-IR in dementia. A possible advantageous role of PON1 in dementia development

2013 ◽  
Vol 324 (1-2) ◽  
pp. 172-175 ◽  
Author(s):  
Małgorzata Bednarska-Makaruk ◽  
Ałła Graban ◽  
Wanda Lipczyńska-Łojkowska ◽  
Anna Bochyńska ◽  
Maria Rodo ◽  
...  
Keyword(s):  
Serum Insulin ◽  
Insulin Level ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Serum Insulin Level ◽  
Positive Correlation

Adverse effect of DEHP exposure on the serum insulin level of Balb/c mice

2016 ◽  
Vol 12 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Jing Wang ◽  
Jinquan Li ◽  
Kashif Rafiq Zahid ◽  
Kun Wang ◽  
Yan Qian ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Serum Insulin ◽  
Insulin Level ◽  
Serum Insulin Level ◽  
Dehp Exposure
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