scholarly journals The Effect of Post warming Culture Period Between Thawing and Transfer of Cryopreserved Embryos on Reproductive Outcomes After In Vitro Fertilization (IVF): A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Luis H. Sordia-Hernandez ◽  
Felipe A. Morales Martinez ◽  
Eduardo Gutierrez Orozco ◽  
Andrea Flores-Rodriguez ◽  
Paloma C. Leyva-Camacho ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Literature Search ◽  
Meta Analysis ◽  
Clinical Pregnancy ◽  
Reproductive Outcomes ◽  
Vitro Fertilization ◽  
Cryopreserved Embryos

Background: The purpose of this study was to evaluate the effect of post warming culture period between thawing and transfer of cryopreserved embryos on reproductive outcomes after in vitro fertilization (IVF). Methods: An extensive literature search was performed using PubMed, EmBase, and the Cochrane library from January 2000 to August 2019. A systematic review and meta–analysis of clinical trials was performed in this manuscript. The trials represented patients with embryo transfers of at least one previously cryopreserved good quality embryo. Main outcome measures of the study included clinical pregnancy rate, live birth rate, miscarriage rate, and ectopic pregnancy rate. Results: A total of 5338 trial/abstracts were identified through a literature search. Totally, five studies were included in the systematic review, and three in the final meta–analysis. The studies included 1717 embryo transfers, 605 after short culture, and 1112 after long culture. The clinical pregnancy rate (CPR) was the most consistent outcome reported. The CPR was slightly better after short time culture with a RR of 1.09 (0.95–1.26, 95%CI) but this difference was not statistically significant. The great heterogenicity in the results reported in the included studies made it impossible to compare all planned outcomes. Conclusion: There are no differences in reproductive outcomes if cryopreserved embryos are transferred after overnight culture or after two hours of culture following thawing. Due to small number and the poor quality of trials reported on this topic, the results of this review should be treated with caution.

scholarly journals Efficacy of intralipid administration to improve in vitro fertilization outcomes: A systematic review and meta-analysis

2021 ◽  
Vol 48 (3) ◽  
pp. 203-210
Author(s):  
E Jung Han ◽  
Hye Nam Lee ◽  
Min Kyoung Kim ◽  
Sang Woo Lyu ◽  
Woo Sik Lee
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Live Birth ◽  
Meta Analysis ◽  
Clinical Pregnancy ◽  
Implantation Failure ◽  
Ongoing Pregnancy ◽  
Vitro Fertilization

We performed a systematic review and meta-analysis to evaluate whether intralipid administration improved the outcomes of in vitro fertilization. Online databases (PubMed, Cochrane Library, Medline, and Embase) were searched until March 2020. Only randomized controlled trials (RCTs) that assessed the role of intralipid administration during in vitro fertilization were considered. We analyzed the rates of clinical pregnancy and live birth as primary outcomes. Secondary outcomes included the rates of chemical pregnancy, ongoing pregnancy, and missed abortion. We reviewed and assessed the eligibility of 180 studies. Five RCTs including 840 patients (3 RCTs: women with repeated implantation failure, 1 RCT: women with recurrent spontaneous abortion, 1 RCT: women who had experienced implantation failure more than once) met the selection criteria. When compared with the control group, intralipid administration significantly improved the clinical pregnancy rate (risk ratio [RR], 1.48; 95% confidence interval [CI], 1.23–1.79), ongoing pregnancy rate (RR, 1.82; 95% CI, 1.31–2.53), and live birth rate (RR, 1.85; 95% CI, 1.44–2.38). However, intralipid administration had no beneficial effect on the miscarriage rate (RR, 0.75; 95% CI, 0.48–1.17). A funnel plot analysis revealed no publication bias. Our findings suggest that intralipid administration may benefit women undergoing in vitro fertilization, especially those who have experienced repeated implantation failure or recurrent spontaneous abortion. However, larger, well-designed studies are needed to confirm these findings.

Increased clinical pregnancy rates by using hyaluronan in in-vitro fertilization: a systematic review and meta-analysis

2008 ◽  
Vol 90 ◽  
pp. S349 ◽  
Author(s):  
E.M. Kolibianakis ◽  
K. Loutradi ◽  
C.A. Venetis ◽  
E.G. Papanikolaou ◽  
T.B. Tarlatzi ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Meta Analysis ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Vitro Fertilization ◽  
Clinical Pregnancy Rates

scholarly journals The effects of acupuncture on rates of clinical pregnancy among women undergoing in vitro fertilization: a systematic review and meta-analysis

2013 ◽  
Vol 19 (6) ◽  
pp. 696-713 ◽  
Author(s):  
Eric Manheimer ◽  
Daniëlle van der Windt ◽  
Ke Cheng ◽  
Kristen Stafford ◽  
Jianping Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Meta Analysis ◽  
Clinical Pregnancy ◽  
Vitro Fertilization

scholarly journals Transcutaneous Electrical Acupoint Stimulation for Pregnancy Outcomes in Women Undergoing In Vitro Fertilization: A Protocol of Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Han Yang ◽  
Juan Li ◽  
Guixing Xu ◽  
Zihao Zou ◽  
Mingsheng Sun ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Childbearing Age ◽  
Ongoing Pregnancy Rate ◽  
Vitro Fertilization ◽  
Acupoint Stimulation

Abstract Background Infertility is a common health problem affecting couples at childbearing age. The proposal of in vitro fertilization (IVF) solves the problem of infertility to a certain extent. However, the average IVF success rates are low. Some studies conclude that transcutaneous electrical acupoint stimulation (TEAS) could improve pregnancy outcomes in women undergoing IVF. In consideration of the lack of comprehensive synthesis and evaluation of existing evidence, conducting a systematic review and meta-analysis is planned to determine whether TEAS is effective and safe to improve the pregnancy outcomes for women undergoing IVF. Methods Eight online databases will be searched from inception to June 2021. In addition, four clinical trial registries will also be searched, relevant references will be screened, and experts will be consulted for possible eligible studies. Randomized controlled trials (RCTs) which included patients with infertility who underwent IVF and used TEAS as the main adjuvant treatment versus non-TEAS or sham TEAS control will be included. The clinical pregnancy rate will be considered as the primary outcome. Ongoing pregnancy rate, miscarriage rate, live birth rate, emotion-related indicators, adverse events related to interventions, and other relevant indicators will be regarded as secondary outcomes. The selection, data extraction, and risk of bias assessment will be conducted by two independent researchers using Endnote software V.9.1 and RevMan software V.5.3. Moreover, data synthesis will be conducted using RevMan software V.5.3 and R software V.3.6.1. Ethics and dissemination: Ethical approval is not necessary because the current study will not include the original information of the individuals. We plan to publish the results in a peer-reviewed journal or disseminated in relevant conferences. Systematic review registration: PROSPERO registration number: CRD42021238871

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