Higher clinical pregnancy rate with in-vitro fertilization versus intracytoplasmic sperm injection in treatment of non-male factor infertility: Systematic review and meta-analysis

2020 ◽  
Vol 49 (6) ◽  
pp. 101706 ◽  
Author(s):  
Ahmed M. Abbas ◽  
Reda S. Hussein ◽  
Mohamed A. Elsenity ◽  
Ihab I. Samaha ◽  
Karim A. El Etriby ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Intracytoplasmic Sperm Injection ◽  
Meta Analysis ◽  
Clinical Pregnancy ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Vitro Fertilization

scholarly journals The Effect of Post warming Culture Period Between Thawing and Transfer of Cryopreserved Embryos on Reproductive Outcomes After In Vitro Fertilization (IVF): A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Luis H. Sordia-Hernandez ◽  
Felipe A. Morales Martinez ◽  
Eduardo Gutierrez Orozco ◽  
Andrea Flores-Rodriguez ◽  
Paloma C. Leyva-Camacho ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Literature Search ◽  
Meta Analysis ◽  
Clinical Pregnancy ◽  
Reproductive Outcomes ◽  
Vitro Fertilization ◽  
Cryopreserved Embryos

Background: The purpose of this study was to evaluate the effect of post warming culture period between thawing and transfer of cryopreserved embryos on reproductive outcomes after in vitro fertilization (IVF). Methods: An extensive literature search was performed using PubMed, EmBase, and the Cochrane library from January 2000 to August 2019. A systematic review and meta–analysis of clinical trials was performed in this manuscript. The trials represented patients with embryo transfers of at least one previously cryopreserved good quality embryo. Main outcome measures of the study included clinical pregnancy rate, live birth rate, miscarriage rate, and ectopic pregnancy rate. Results: A total of 5338 trial/abstracts were identified through a literature search. Totally, five studies were included in the systematic review, and three in the final meta–analysis. The studies included 1717 embryo transfers, 605 after short culture, and 1112 after long culture. The clinical pregnancy rate (CPR) was the most consistent outcome reported. The CPR was slightly better after short time culture with a RR of 1.09 (0.95–1.26, 95%CI) but this difference was not statistically significant. The great heterogenicity in the results reported in the included studies made it impossible to compare all planned outcomes. Conclusion: There are no differences in reproductive outcomes if cryopreserved embryos are transferred after overnight culture or after two hours of culture following thawing. Due to small number and the poor quality of trials reported on this topic, the results of this review should be treated with caution.

scholarly journals Efficacy of intralipid administration to improve in vitro fertilization outcomes: A systematic review and meta-analysis

2021 ◽  
Vol 48 (3) ◽  
pp. 203-210
Author(s):  
E Jung Han ◽  
Hye Nam Lee ◽  
Min Kyoung Kim ◽  
Sang Woo Lyu ◽  
Woo Sik Lee
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Live Birth ◽  
Meta Analysis ◽  
Clinical Pregnancy ◽  
Implantation Failure ◽  
Ongoing Pregnancy ◽  
Vitro Fertilization

We performed a systematic review and meta-analysis to evaluate whether intralipid administration improved the outcomes of in vitro fertilization. Online databases (PubMed, Cochrane Library, Medline, and Embase) were searched until March 2020. Only randomized controlled trials (RCTs) that assessed the role of intralipid administration during in vitro fertilization were considered. We analyzed the rates of clinical pregnancy and live birth as primary outcomes. Secondary outcomes included the rates of chemical pregnancy, ongoing pregnancy, and missed abortion. We reviewed and assessed the eligibility of 180 studies. Five RCTs including 840 patients (3 RCTs: women with repeated implantation failure, 1 RCT: women with recurrent spontaneous abortion, 1 RCT: women who had experienced implantation failure more than once) met the selection criteria. When compared with the control group, intralipid administration significantly improved the clinical pregnancy rate (risk ratio [RR], 1.48; 95% confidence interval [CI], 1.23–1.79), ongoing pregnancy rate (RR, 1.82; 95% CI, 1.31–2.53), and live birth rate (RR, 1.85; 95% CI, 1.44–2.38). However, intralipid administration had no beneficial effect on the miscarriage rate (RR, 0.75; 95% CI, 0.48–1.17). A funnel plot analysis revealed no publication bias. Our findings suggest that intralipid administration may benefit women undergoing in vitro fertilization, especially those who have experienced repeated implantation failure or recurrent spontaneous abortion. However, larger, well-designed studies are needed to confirm these findings.

Increased clinical pregnancy rates by using hyaluronan in in-vitro fertilization: a systematic review and meta-analysis

2008 ◽  
Vol 90 ◽  
pp. S349 ◽  
Author(s):  
E.M. Kolibianakis ◽  
K. Loutradi ◽  
C.A. Venetis ◽  
E.G. Papanikolaou ◽  
T.B. Tarlatzi ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Meta Analysis ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Vitro Fertilization ◽  
Clinical Pregnancy Rates

scholarly journals Results and experiences after 1000 IVF cycles at the Clinic for gynecology and obstetrics in Novi Sad

2011 ◽  
Vol 64 (11-12) ◽  
pp. 565-569
Author(s):  
Vesna Kopitovic ◽  
Stevan Milatovic ◽  
Aleksandra Trninic-Pjevic ◽  
Artur Bjelica ◽  
Irena Bujas ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Intracytoplasmic Sperm Injection ◽  
Clinical Pregnancy ◽  
Reproductive Age ◽  
Male Factor ◽  
Fertilization Program ◽  
Vitro Fertilization ◽  
Gynecology And Obstetrics ◽  
Novi Sad

Introduction. Infertility affects 15-17% of reproductive age couples in our country, and 10-15% of couples worldwide. The aim of this paper was to present results and experience gained after the first 1000 cycles of the national In Vitro Fertilization (IVF) program, to offer professional standard of work in our country and to compare it with results obtained in Europe and worldwide. Material and methods. The study prospectively included 1000 women who had undergone national In Vitro Fertilization program from October 2006 until November 2009 at the Department of Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi Sad. Results. The analysis included 1000 in vitro fertilization cycles. Male factor infertility was the leading cause (56.9%) followed by tubal factor (45.9%). The classic method of in vitro fertilization constituted 72.3% of all cycles, while intracytoplasmic sperm injection (ICSI) method was used in 27.7% of all cycles. The average number of embryos transferred was 2.67. The cycle cancellation rate was 14.10% and the aspiration rate was 94.40%. The clinical pregnancy and live birth rate were 33.41% and 26.78% per embryo transfer, respectively. Discussion and conclusion. The results in our study showed that in our setting there are far less intracytoplasmic sperm injection cycles compared with the European average of 66.5% of all fresh cycles, and that we transferred more embryos on average. Our success rates are comparable with those in other European countries where the clinical pregnancy rates per aspiration and per transfer for in vitro fertilization were 29 and 32.4%, respectively in the period of observation. For intracytoplasmic sperm injection, the corresponding rates were 29.9 and 33%.

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