scholarly journals A very rare case report:Renal cell carcinoma metastasizing to the tonsil after 5 years of radical nephrectomy

2019 ◽  
Vol 6 (12) ◽  
pp. 4654-4656
Author(s):  
Yücel Kılıçkap ◽  
Mehmet Aktaş ◽  
Lezgin Kıran ◽  
Abdullah Gedik ◽  
M.Kamuran Bircan
Keyword(s):  
Cell Carcinoma ◽  
Rare Case ◽  
Clear Cell ◽  
Histopathological Examination ◽  
Collecting Duct ◽  
Neck Region ◽  
Duct Carcinoma ◽  
Head And Neck Region ◽  
Collecting Duct Carcinoma

Renal cell carcinoma (RCC), is the most common kidney cancer, that accounts for approximately  90% of all adult renal malignancies with 30% of patients presenting with metastasis at initial diagnosis.There are several reports of metastases developing after 10-20 years even if curative nephrectomy has been made. Clear cell (60%-75%), papillary (10%-15%), chromophobe (5%), and collecting duct carcinoma are well characterized subtypes of RCC.Renal cell carcinoma mainly metastasizes to the lungs,the bones,the liver,the lymph nodes and brain.Metastasis to the head and neck region is rare.In this case report we present a tonsil metastasis after 5 years of nephrectomy.Surgery with histopathological examination confirmed that metastasis of clear cell carcinom.The patient was successfully treated by surgery and referred to oncology.Later he was out of our follow-up.

scholarly journals Collision tumor of the kidney composed of clear cell carcinoma and collecting duct carcinoma treated with cabozantinib and nivolumab

2020 ◽  
Vol 2 ◽  
pp. 100039
Author(s):  
Carlos Eduardo Salazar-Mejía ◽  
Víctor Manuel Oyervides-Juárez ◽  
Blanca Otilia Wimer-Castillo ◽  
Oscar Vidal-Gutiérrez ◽  
Raquel Garza-Guajardo ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Collecting Duct ◽  
Collision Tumor ◽  
Duct Carcinoma ◽  
Collecting Duct Carcinoma

scholarly journals Collecting Duct Carcinoma: A Rare Entity

2020 ◽  
Vol 4 (1) ◽  
pp. 129
Author(s):  
Ferdinant Martinus Djawa ◽  
Anny Setijo Rahaju
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Histopathological Examination ◽  
Collecting Duct ◽  
Abdominal Mass ◽  
Left Kidney ◽  
Renal Tumors ◽  
Duct Carcinoma ◽  
Collecting Duct Carcinoma

ABSTRACTCollecting duct carcinoma is a rare and highly aggressive subtype of renal cell carcinoma. The incidence rate is less than 1-2% of all renal tumors and usually, affect middle-aged adult, commonly in men. We reported a 76-year-old man complains of an intermittent painless gross hematuria, abdominal mass and left flank pain for approximately three months. The CT abdomen showed a slightly enhancing solid mass in the left kidney and para-aorta lymphadenopathy. Cut surfaces of the kidney showed a solid-cystic and ill-defined greyish-white tumor. Microscopically, tumor formed solid sheets and tubulopapillary structures lined by neoplastic cells, hobnailing nuclei, abnormal mitotic, and a desmoplastic stroma with lymphoplasmacytic infiltration, and the immunochemical profile were PAX8 (+) /p63 (-). Based on these findings, the diagnosis was a collecting duct carcinoma. This tumor arising from the collecting duct of Bellini in the renal medulla, accounts for less than 1-2% of all renal masses and important to be distinguished from other tumors due to differences in prognosis and therapeutic. Histopathological examination is needed to establish the diagnosis. A case of collecting duct carcinoma that occurred in a 76-year-old man has been reported. A definitive diagnosis can only be done with a detailed histopathological examination for patient management benefits.Keywords          : renal cell carcinoma, collecting duct carcinoma, urothelial carcinoma, PAX8, p63

scholarly journals Comprehensive Immunoprofiles of Renal Cell Carcinoma Subtypes

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 602 ◽  
Author(s):  
Moonsik Kim ◽  
Jin Woo Joo ◽  
Seok Joo Lee ◽  
Yoon Ah Cho ◽  
Cheol Keun Park ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Collecting Duct ◽  
Cathepsin K ◽  
Renal Tumors ◽  
Duct Carcinoma ◽  
Epithelial Tumors ◽  
Papillary Type

In recent years, renal epithelial tumors have been among the fastest reclassifying tumors, requiring updates to the tumor classification system. Nonetheless, immunohistochemistry (IHC) remains the most widely used tool for renal epithelial tumors. In this proposal, we aimed to create the most efficient IHC panel for categorizing the diverse subtypes of renal tumors, and to find out more specific immunohistochemical results in each subtype or each antibody. A total of 214 renal tumors were analyzed using 10 possible IHC markers to differentiate subtypes, including three major renal cell carcinoma (RCC) subtypes, clear-cell type (50 cases), papillary type (50 cases), and chromophobe type (20 cases), and minor subtypes (MiT RCC, 13 cases; collecting duct carcinoma, 5 cases; and oncocytoma, 10 cases). A triple immunomarker (cytokeratin 7 (CK7)-carbonic anhydrase IX (CAIX)- alpha-methylacyl-CoA racemase (AMACR)) panel is useful in particular high-grade clear-cell tumors. If IHC remains ambiguous, the use of an adjunctive panel can be suggested, including CD10, epithelial membrane antigen, cathepsin K, c-kit, hepatocyte nuclear factor 1-β, and E-cadherin. For an efficient immunohistochemical strategy for subtyping of RCC, we conclude that the CK7-CAIX-AMACR panel is the best primary choice for screening subtyping.

Pazopanib for treatment of metastatic renal cell carcinoma with non-clear cell histology: Single-arm, open label, multicenter, phase II study.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 577-577 ◽  
Author(s):  
Ki Sun Jung ◽  
Jinhyun Cho ◽  
Kwai Han Yoo ◽  
Se Hoon Park ◽  
Jae-Lyun Lee ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Disease Progression ◽  
Phase Ii ◽  
Renal Cell ◽  
Clear Cell ◽  
Phase Ii Study ◽  
Collecting Duct ◽  
Open Label

577 Background: Targeted therapy has shown remarkable treatment efficacy on the outcomes of patients with advanced renal cell carcinoma. However, this advance for treatment outcomes with targeted agents has been limited to patents with clear cell histology. The optimal treatment strategy for metastatic non-clear cell renal cell carcinoma (nccRCC) remains uncertained. Recently, several vascular endothelial growth factor inhibitors have shown efficacies for nccRCC. Thus, we designed a single-arm, open label phase II study to determine the efficacy and toxicity of pazopanib in patients with nccRCC. Methods: Patients with metastatic nccRCC except for collecting duct or sarcomatoid type received 800mg/day of pazopanib daily until progression of the disease or intolerable toxicity was observed. The primary objectives were progression free survival (PFS) and second objectives were overall survival (OS), treatment response and safety profiles. Results: A total of 29 eligible patients were enrolled from September 2012 to August 2014. The median age of the patients was 59 years (range, 30-77 years) and 21 patients were male. The median PFS was 8.3 months (95% CI, 4.0-12.6 months) and median OS was not reached (range, 1.5-34.7 months). Among all 29 patients, five patients (17.2%) are ongoing treatment without disease progression. Disease progression was observed in 16 patients (55.2%) during follow up period. Five patients (17.2%) experienced a treatment-related toxicity of grade 3 or more during the study and they stopped treatment in the end. Eight patients (27%) expired during follow up period but, there were no treatment-related deaths. Conclusions: This prospective phase II study showed that pazopanib demonstrated promising activity and tolerable safety in patients with nccRCC (ClinicalTrials.gov NCT01538238). Clinical trial information: NCT01538238.

scholarly journals Dermoid cyst over the left sphenoid in a child: a rare case report

2019 ◽  
Vol 5 (6) ◽  
pp. 1688
Author(s):  
Andrews Navin Kumar ◽  
Anubhav Shivpuri ◽  
Sandeep Mehta ◽  
Shanender Singh Sambyal
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Dermoid Cyst ◽  
Rare Case ◽  
Histopathological Examination ◽  
Neck Region ◽  
Surgical Removal ◽  
Cystic Lesions ◽  
Head And Neck Region ◽  
Rare Case Report

<p class="abstract">In this case report a bony swelling was noticed clinically which had a cystic presentation in CT imaging. After surgical removal it was sent for histopathological examination and was diagnosed as dermoid cyst. Dermoid cyst is rarely encountered lesions of head and neck region so most frequently misdiagnosed. Though this lesion is very rare but should be considered as a differential diagnosis while evaluation cystic lesions of head and neck region.</p>

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